Altered CD8+ T cell responses to selected Epstein–Barr virus immunodominant epitopes in patients with multiple sclerosis

SUMMARY An increased frequency of antiviral CD8+ T cells is seen in chronic viral infections. During herpes virus infections the expanded CD8+ T cells are thought to control the reactivation of the latent infection. Because multiple sclerosis (MS), a presumed autoimmune disease of the central nervou...

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Veröffentlicht in:	Clinical and experimental immunology 2003-04, Vol.132 (1), p.137-143
Hauptverfasser:	HÖLLSBERG, P., HANSEN, H. J., HAAHR, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Viral - immunology Biological and medical sciences Case-Control Studies CD8-Positive T-Lymphocytes - immunology ELIspot Epstein-Barr Virus Infections - immunology Female herpesvirus Herpesvirus 4, Human - immunology HLA HLA-A2 Antigen - immunology HLA-B7 Antigen - immunology Human viral diseases Humans Immunodominant Epitopes - immunology Infectious diseases Lymphocyte Activation Lymphocyte Count lymphocytes Male Medical sciences Middle Aged Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Original peptides Viral diseases Viral diseases of the nervous system
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