Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood
SUMMARY In an unselected cohort of 282 children, serum immunoglobulin (Ig) concentrations were determined shortly after the first presentation with one or more unprovoked epileptic seizures and before the start of treatment with anti‐epileptic drugs (AEDs), and after 9–18 months of AEDs use. At inta...
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| Veröffentlicht in: | Clinical and experimental immunology 2003-04, Vol.132 (1), p.144-151 |
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| creator | CALLENBACH, P. M. C. JOL‐VAN DER ZIJDE, C. M. GEERTS, A. T. ARTS, W. F. M. VAN DONSELAAR, C. A. PETERS, A. C. B. STROINK, H. BROUWER, O. F. VAN TOL, M. J. D. |
| description | SUMMARY
In an unselected cohort of 282 children, serum immunoglobulin (Ig) concentrations were determined shortly after the first presentation with one or more unprovoked epileptic seizures and before the start of treatment with anti‐epileptic drugs (AEDs), and after 9–18 months of AEDs use. At intake, IgA, IgG1, IgG2 and IgG4 concentrations were significantly higher than published reference values in healthy age‐matched controls. In a subset of 127 children, Ig levels at intake were compared with those after AEDs use for 9–18 months. IgA and IgG4 levels had decreased significantly to normal concentrations, but IgG1 and IgG3 levels increased significantly. To determine the influence of AEDs, Ig levels in children who used carbamazepine or valproic acid monotherapy were analysed separately. The use of carbamazepine was associated with a significant decrease of IgA and IgG4 levels, and the use of valproic acid with a significant decrease of IgA and increase of IgG1 levels. In conclusion, humoral immunity is already altered in children shortly after the first presentation with epileptic seizures. Whether this is the consequence of an exogenous event, and to what extent this is related to an interaction of the central nervous system and the immune system, remains to be evaluated. Treatment with AEDs, such as carbamazepine and valproic acid, is associated with significant changes of Ig (sub)class concentrations. |
| doi_str_mv | 10.1046/j.1365-2249.2003.02097.x |
| format | Article |
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In an unselected cohort of 282 children, serum immunoglobulin (Ig) concentrations were determined shortly after the first presentation with one or more unprovoked epileptic seizures and before the start of treatment with anti‐epileptic drugs (AEDs), and after 9–18 months of AEDs use. At intake, IgA, IgG1, IgG2 and IgG4 concentrations were significantly higher than published reference values in healthy age‐matched controls. In a subset of 127 children, Ig levels at intake were compared with those after AEDs use for 9–18 months. IgA and IgG4 levels had decreased significantly to normal concentrations, but IgG1 and IgG3 levels increased significantly. To determine the influence of AEDs, Ig levels in children who used carbamazepine or valproic acid monotherapy were analysed separately. The use of carbamazepine was associated with a significant decrease of IgA and IgG4 levels, and the use of valproic acid with a significant decrease of IgA and increase of IgG1 levels. In conclusion, humoral immunity is already altered in children shortly after the first presentation with epileptic seizures. Whether this is the consequence of an exogenous event, and to what extent this is related to an interaction of the central nervous system and the immune system, remains to be evaluated. Treatment with AEDs, such as carbamazepine and valproic acid, is associated with significant changes of Ig (sub)class concentrations.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1046/j.1365-2249.2003.02097.x</identifier><identifier>PMID: 12653849</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Anticonvulsants - therapeutic use ; Biological and medical sciences ; carbamazepine ; Carbamazepine - therapeutic use ; Case-Control Studies ; Chi-Square Distribution ; Child ; Child, Preschool ; children ; epilepsy ; Epilepsy - drug therapy ; Epilepsy - immunology ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; immunoglobulins ; Immunoglobulins - blood ; Infant ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Netherlands ; Neurology ; Original ; Statistics, Nonparametric ; valproic acid ; Valproic Acid - therapeutic use</subject><ispartof>Clinical and experimental immunology, 2003-04, Vol.132 (1), p.144-151</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Apr 2003</rights><rights>2003 Blackwell Publishing Ltd 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5587-5b2eee19e320050cf45b81026dbbed2826306ef6643bec2935af99d8caf8056e3</citedby><cites>FETCH-LOGICAL-c5587-5b2eee19e320050cf45b81026dbbed2826306ef6643bec2935af99d8caf8056e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808668/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808668/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14674763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12653849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CALLENBACH, P. M. C.</creatorcontrib><creatorcontrib>JOL‐VAN DER ZIJDE, C. M.</creatorcontrib><creatorcontrib>GEERTS, A. T.</creatorcontrib><creatorcontrib>ARTS, W. F. M.</creatorcontrib><creatorcontrib>VAN DONSELAAR, C. A.</creatorcontrib><creatorcontrib>PETERS, A. C. B.</creatorcontrib><creatorcontrib>STROINK, H.</creatorcontrib><creatorcontrib>BROUWER, O. F.</creatorcontrib><creatorcontrib>VAN TOL, M. J. D.</creatorcontrib><creatorcontrib>Dutch Study of Epilepsy in Childhood</creatorcontrib><title>Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>SUMMARY
In an unselected cohort of 282 children, serum immunoglobulin (Ig) concentrations were determined shortly after the first presentation with one or more unprovoked epileptic seizures and before the start of treatment with anti‐epileptic drugs (AEDs), and after 9–18 months of AEDs use. At intake, IgA, IgG1, IgG2 and IgG4 concentrations were significantly higher than published reference values in healthy age‐matched controls. In a subset of 127 children, Ig levels at intake were compared with those after AEDs use for 9–18 months. IgA and IgG4 levels had decreased significantly to normal concentrations, but IgG1 and IgG3 levels increased significantly. To determine the influence of AEDs, Ig levels in children who used carbamazepine or valproic acid monotherapy were analysed separately. The use of carbamazepine was associated with a significant decrease of IgA and IgG4 levels, and the use of valproic acid with a significant decrease of IgA and increase of IgG1 levels. In conclusion, humoral immunity is already altered in children shortly after the first presentation with epileptic seizures. Whether this is the consequence of an exogenous event, and to what extent this is related to an interaction of the central nervous system and the immune system, remains to be evaluated. Treatment with AEDs, such as carbamazepine and valproic acid, is associated with significant changes of Ig (sub)class concentrations.</description><subject>Adolescent</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>carbamazepine</subject><subject>Carbamazepine - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - immunology</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>immunoglobulins</subject><subject>Immunoglobulins - blood</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Netherlands</subject><subject>Neurology</subject><subject>Original</subject><subject>Statistics, Nonparametric</subject><subject>valproic acid</subject><subject>Valproic Acid - therapeutic use</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCX0AWEtwS_BE7NhJIaFlgpUocCmfLcSaNV9l4iRPa_fc43agFLnCyrXne0YwfhDAlOSWFfLPLKZciY6zQOSOE54QRXea3j9DqvvAYrQghOtMpcYbOY9ylp5SSPUVnlEnBVaFX6Gq73099uO5CNXW-j9j32LW-qwfo8Y0fWwwH38EhHt_isQX8cRpdi6_GqT7i0ODNUpxj6znWhlA_Q08a20V4vpwX6Punzbf1l-zy6-ft-sNl5oRQZSYqBgBUA08rCOKaQlSKEibrqoKaKSY5kdBIWfAKHNNc2EbrWjnbKCIk8Av0_tT3MFV7qB3042A7cxj83g5HE6w3f1Z635rr8NNQRZSUKjV4vTQYwo8J4mj2PjroOttDmKIpOeWCU_FPkKqSc8KLBL78C9yFaejTLxiqpdIy2UmQOkFuCDEO0NyPTImZ_ZqdmTWaWaOZ_Zo7v-Y2RV_8vvJDcBGagFcLYKOzXTPY3vn4wBWyLErJE_fuxN0kgcf_HsCsN9v5xn8BdWPBXA</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>CALLENBACH, P. M. C.</creator><creator>JOL‐VAN DER ZIJDE, C. M.</creator><creator>GEERTS, A. T.</creator><creator>ARTS, W. F. M.</creator><creator>VAN DONSELAAR, C. A.</creator><creator>PETERS, A. C. B.</creator><creator>STROINK, H.</creator><creator>BROUWER, O. F.</creator><creator>VAN TOL, M. J. D.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200304</creationdate><title>Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood</title><author>CALLENBACH, P. M. C. ; JOL‐VAN DER ZIJDE, C. M. ; GEERTS, A. T. ; ARTS, W. F. M. ; VAN DONSELAAR, C. A. ; PETERS, A. C. B. ; STROINK, H. ; BROUWER, O. F. ; VAN TOL, M. J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5587-5b2eee19e320050cf45b81026dbbed2826306ef6643bec2935af99d8caf8056e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>carbamazepine</topic><topic>Carbamazepine - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - immunology</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>immunoglobulins</topic><topic>Immunoglobulins - blood</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Netherlands</topic><topic>Neurology</topic><topic>Original</topic><topic>Statistics, Nonparametric</topic><topic>valproic acid</topic><topic>Valproic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CALLENBACH, P. M. C.</creatorcontrib><creatorcontrib>JOL‐VAN DER ZIJDE, C. M.</creatorcontrib><creatorcontrib>GEERTS, A. T.</creatorcontrib><creatorcontrib>ARTS, W. F. M.</creatorcontrib><creatorcontrib>VAN DONSELAAR, C. A.</creatorcontrib><creatorcontrib>PETERS, A. C. B.</creatorcontrib><creatorcontrib>STROINK, H.</creatorcontrib><creatorcontrib>BROUWER, O. F.</creatorcontrib><creatorcontrib>VAN TOL, M. J. D.</creatorcontrib><creatorcontrib>Dutch Study of Epilepsy in Childhood</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CALLENBACH, P. M. C.</au><au>JOL‐VAN DER ZIJDE, C. M.</au><au>GEERTS, A. T.</au><au>ARTS, W. F. M.</au><au>VAN DONSELAAR, C. A.</au><au>PETERS, A. C. B.</au><au>STROINK, H.</au><au>BROUWER, O. F.</au><au>VAN TOL, M. J. D.</au><aucorp>Dutch Study of Epilepsy in Childhood</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2003-04</date><risdate>2003</risdate><volume>132</volume><issue>1</issue><spage>144</spage><epage>151</epage><pages>144-151</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>SUMMARY
In an unselected cohort of 282 children, serum immunoglobulin (Ig) concentrations were determined shortly after the first presentation with one or more unprovoked epileptic seizures and before the start of treatment with anti‐epileptic drugs (AEDs), and after 9–18 months of AEDs use. At intake, IgA, IgG1, IgG2 and IgG4 concentrations were significantly higher than published reference values in healthy age‐matched controls. In a subset of 127 children, Ig levels at intake were compared with those after AEDs use for 9–18 months. IgA and IgG4 levels had decreased significantly to normal concentrations, but IgG1 and IgG3 levels increased significantly. To determine the influence of AEDs, Ig levels in children who used carbamazepine or valproic acid monotherapy were analysed separately. The use of carbamazepine was associated with a significant decrease of IgA and IgG4 levels, and the use of valproic acid with a significant decrease of IgA and increase of IgG1 levels. In conclusion, humoral immunity is already altered in children shortly after the first presentation with epileptic seizures. Whether this is the consequence of an exogenous event, and to what extent this is related to an interaction of the central nervous system and the immune system, remains to be evaluated. Treatment with AEDs, such as carbamazepine and valproic acid, is associated with significant changes of Ig (sub)class concentrations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12653849</pmid><doi>10.1046/j.1365-2249.2003.02097.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Anticonvulsants - therapeutic use Biological and medical sciences carbamazepine Carbamazepine - therapeutic use Case-Control Studies Chi-Square Distribution Child Child, Preschool children epilepsy Epilepsy - drug therapy Epilepsy - immunology Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Immunoglobulin A - blood Immunoglobulin G - blood immunoglobulins Immunoglobulins - blood Infant Male Medical sciences Nervous system (semeiology, syndromes) Netherlands Neurology Original Statistics, Nonparametric valproic acid Valproic Acid - therapeutic use |
| title | Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood |
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