Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation

Cdc42-associated tyrosine kinase 1 (ACK1) is a specific down-stream effector of Cdc42, a Rho family small G-protein. Previous studies have shown that ACK1 interacts with clathrin heavy chain and is involved in clathrin-coated vesicle endocytosis. Here we report that ACK1 interacted with epidermal gr...

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Veröffentlicht in:	Molecular biology of the cell 2007-03, Vol.18 (3), p.732-742
Hauptverfasser:	Shen, Feng, Lin, Qiong, Gu, Yan, Childress, Chandra, Yang, Wannian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cercopithecus aethiops CHO Cells Conserved Sequence COS Cells Cricetinae Cricetulus Epidermal Growth Factor - pharmacology HeLa Cells Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Mice Molecular Sequence Data Protein Binding - drug effects Protein Processing, Post-Translational - drug effects Protein Structure, Tertiary - drug effects Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - metabolism Receptor, Epidermal Growth Factor - metabolism Signal Transduction - drug effects Ubiquitin - metabolism
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