Detection, epitope‐mapping and function of anti‐Fas autoantibody in patients with silicosis

Summary Dysregulation of apoptosis through the Fas–Fas ligand pathway is associated with the onset of autoimmune disease. Since autoantibodies directed against unknown antigens are present in the sera of these patients, sera samples were examined for the presence of autoantibodies directed against t...

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Veröffentlicht in:	Immunology 2005-09, Vol.116 (1), p.21-29
Hauptverfasser:	Takata‐Tomokuni, Akiko, Ueki, Ayako, Shiwa, Mieko, Isozaki, Yumika, Hatayama, Tamayo, Katsuyama, Hironobu, Hyodoh, Fuminori, Fujimoto, Wataru, Ueki, Hiroaki, Kusaka, Masayasu, Arikuni, Hisashi, Otsuki, Takemi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Amino Acids - analysis anti‐Fas autoantibody Autoantibodies - blood Autoantibodies - immunology autoimmune diseases Autoimmune Diseases - immunology Blotting, Western - methods Cell Division Epitope Mapping fas Receptor - genetics fas Receptor - immunology fas Receptor - metabolism Female Humans Lupus Erythematosus, Systemic - immunology Male Middle Aged Original Protein Array Analysis - methods RNA, Small Interfering - genetics Scleroderma, Systemic - immunology silicosis Silicosis - immunology siRNA Tumor Cells, Cultured
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