Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27
Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported...
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| Veröffentlicht in: | American journal of human genetics 1995-10, Vol.57 (4), p.911-919 |
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| creator | DE-FANG LUO BUI, M. M MUIR, A MACLAREN, N. K THOMSON, G JIN-XIONG SHE |
| description | Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages. |
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M ; MUIR, A ; MACLAREN, N. K ; THOMSON, G ; JIN-XIONG SHE</creator><creatorcontrib>DE-FANG LUO ; BUI, M. M ; MUIR, A ; MACLAREN, N. K ; THOMSON, G ; JIN-XIONG SHE</creatorcontrib><description>Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages.</description><identifier>ISSN: 0002-9297</identifier><identifier>EISSN: 1537-6605</identifier><identifier>PMID: 7573053</identifier><identifier>CODEN: AJHGAG</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Biological and medical sciences ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 15 ; Chromosomes, Human, Pair 6 ; Diabetes Mellitus, Type 1 - genetics ; Diabetes. Impaired glucose tolerance ; DNA, Satellite - analysis ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Genetic Heterogeneity ; Genetic Linkage ; Genetic Predisposition to Disease ; Humans ; Lod Score ; Medical sciences ; Nuclear Family</subject><ispartof>American journal of human genetics, 1995-10, Vol.57 (4), p.911-919</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801491/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801491/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3662307$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7573053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE-FANG LUO</creatorcontrib><creatorcontrib>BUI, M. M</creatorcontrib><creatorcontrib>MUIR, A</creatorcontrib><creatorcontrib>MACLAREN, N. K</creatorcontrib><creatorcontrib>THOMSON, G</creatorcontrib><creatorcontrib>JIN-XIONG SHE</creatorcontrib><title>Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages.</description><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Chromosomes, Human, Pair 15</subject><subject>Chromosomes, Human, Pair 6</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA, Satellite - analysis</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Genetic Heterogeneity</subject><subject>Genetic Linkage</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Medical sciences</subject><subject>Nuclear Family</subject><issn>0002-9297</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAUhYsoOj5-gpCFiC4CeTRJuxHE8QWKG12XNLkZI2nSaVrBjb_dgoPoytVdnI-Pw7lbxYIKrrCURGwXC0IIwzWr1V6xn_MbIZRWhO8Wu0ooTgRfFJ-XzoEZweLsW9xrP6BO972PK5Qc0iimdwgoT9lAP_rWBz9-oBVEQGNCPuYp-Igt9BAtxBFZr1sYIaMOwoxOGZ3dL5eP1TlKEZnXIXUppw6QXDOB10wdFjtOhwxHm3tQvNxcP1_d4Yen2_urywfcc0ZHbHRVcdcSqoyzdctaqCglupWypEyCo9pYZpSsFGe8ri2zUgswtHTADLeWHxQX395-ajuwZu466ND0g-_08NEk7Zu_SfSvzSq9N_NetKzpLDjdCIa0niCPTefnTULQEdKUG6VExVlJ_gWprIkQvJzB49-VfrpsXjPnJ5tcZ6ODG3Q0Pv9gXErGieJfmoaaMw</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>DE-FANG LUO</creator><creator>BUI, M. M</creator><creator>MUIR, A</creator><creator>MACLAREN, N. K</creator><creator>THOMSON, G</creator><creator>JIN-XIONG SHE</creator><general>University of Chicago Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19951001</creationdate><title>Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27</title><author>DE-FANG LUO ; BUI, M. M ; MUIR, A ; MACLAREN, N. K ; THOMSON, G ; JIN-XIONG SHE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p321t-ca883fb017cfd9b2be8110ab664126ef1acd2c768732399d2d6a5ec14fe2c3dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Chromosomes, Human, Pair 15</topic><topic>Chromosomes, Human, Pair 6</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA, Satellite - analysis</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Genetic Heterogeneity</topic><topic>Genetic Linkage</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Medical sciences</topic><topic>Nuclear Family</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE-FANG LUO</creatorcontrib><creatorcontrib>BUI, M. M</creatorcontrib><creatorcontrib>MUIR, A</creatorcontrib><creatorcontrib>MACLAREN, N. K</creatorcontrib><creatorcontrib>THOMSON, G</creatorcontrib><creatorcontrib>JIN-XIONG SHE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE-FANG LUO</au><au>BUI, M. M</au><au>MUIR, A</au><au>MACLAREN, N. K</au><au>THOMSON, G</au><au>JIN-XIONG SHE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>57</volume><issue>4</issue><spage>911</spage><epage>919</epage><pages>911-919</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>7573053</pmid><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 6 Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance DNA, Satellite - analysis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Genetic Heterogeneity Genetic Linkage Genetic Predisposition to Disease Humans Lod Score Medical sciences Nuclear Family |
| title | Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27 |
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