Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis

A unique characteristic of the autoimmune liver disease primary biliary cirrhosis (PBC) is the presence of high-titer and extremely specific autoantibodies to the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Autoantibodies to PDC-E2 antigen have only been detected in patients with di...

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Veröffentlicht in:	Blood 2007-03, Vol.109 (5), p.2001-2007
Hauptverfasser:	Bellucci, Roberto, Oertelt, Sabine, Gallagher, Meagan, Li, Sigui, Zorn, Emmanuel, Weller, Edie, Porcheray, Fabrice, Alyea, Edwin P., Soiffer, Robert J., Munshi, Nikhil C., Gershwin, M. Eric, Ritz, Jerome
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies - blood Antibodies - immunology Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Cell Line, Tumor Dihydrolipoyllysine-Residue Acetyltransferase - immunology Epitope Mapping Female Health Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - adverse effects Humans Immunobiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Liver Cirrhosis, Biliary - blood Liver Cirrhosis, Biliary - immunology Liver Cirrhosis, Biliary - surgery Male Medical sciences Middle Aged Mitochondrial Proteins - immunology Paraproteinemias - immunology Paraproteinemias - surgery Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Homologous - immunology
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