Asporin repeat polymorphism in rheumatoid arthritis
Background: Asporin belongs to a family of proteins associated with the cartilage matrix. Objective: To investigate the role of the functional polymorphism consisting of an aspartic acid (D) repeat polymorphism located in the ASPN gene in the susceptibility to and clinical outcome of rheumatoid arth...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2007-01, Vol.66 (1), p.118-120 |
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| creator | Torres, B Orozco, G García-Lozano, J R Oliver, J Fernández, O González-Gay, M A Balsa, A García, A Pascual-Salcedo, D López-Nevot, M A Núñez-Roldán, A Martín, J González-Escribano, M F |
| description | Background: Asporin belongs to a family of proteins associated with the cartilage matrix. Objective: To investigate the role of the functional polymorphism consisting of an aspartic acid (D) repeat polymorphism located in the ASPN gene in the susceptibility to and clinical outcome of rheumatoid arthritis. Methods: A total of 803 Spanish Caucasian patients with rheumatoid arthritis and 904 controls of the same ethnic origin and matched for age and sex were included in the study. The asporin D repeat polymorphism was genotyped using polymerase chain reaction with a fluorescent primer. Results: No significant differences were detected in the distribution of the 10 alleles found in our population on comparing patients with rheumatoid arthritis with control groups. Nevertheless, individuals bearing D14 produced rheumatoid factor more often than the rest (85.7% v 72.1%, p = 0.006, odds ratio (OR) = 2.35, 95% confidence interval 1.21 to 4.50), and the mean (SD) onset age was higher in the group of individuals bearing D13 (50.09 (13.94)) compared with the rest (47.21 (14.31)), although the difference did not reach significance (p = 0.06). Conclusion: The results do not support a major role for asporin D repeat polymorphism in the susceptibility to rheumatoid arthritis. Nevertheless, they support the influence of this gene on the outcome of the disease. |
| doi_str_mv | 10.1136/ard.2006.055426 |
| format | Article |
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Objective: To investigate the role of the functional polymorphism consisting of an aspartic acid (D) repeat polymorphism located in the ASPN gene in the susceptibility to and clinical outcome of rheumatoid arthritis. Methods: A total of 803 Spanish Caucasian patients with rheumatoid arthritis and 904 controls of the same ethnic origin and matched for age and sex were included in the study. The asporin D repeat polymorphism was genotyped using polymerase chain reaction with a fluorescent primer. Results: No significant differences were detected in the distribution of the 10 alleles found in our population on comparing patients with rheumatoid arthritis with control groups. Nevertheless, individuals bearing D14 produced rheumatoid factor more often than the rest (85.7% v 72.1%, p = 0.006, odds ratio (OR) = 2.35, 95% confidence interval 1.21 to 4.50), and the mean (SD) onset age was higher in the group of individuals bearing D13 (50.09 (13.94)) compared with the rest (47.21 (14.31)), although the difference did not reach significance (p = 0.06). Conclusion: The results do not support a major role for asporin D repeat polymorphism in the susceptibility to rheumatoid arthritis. Nevertheless, they support the influence of this gene on the outcome of the disease.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2006.055426</identifier><identifier>PMID: 16707531</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Age ; Age of Onset ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - genetics ; ASPN ; asporin gene ; Biological and medical sciences ; Case-Control Studies ; Chi-Square Distribution ; Concise Report ; Confidence intervals ; Deoxyribonucleic acid ; Disease ; Diseases of the osteoarticular system ; DNA ; Extracellular matrix ; Extracellular Matrix Proteins - genetics ; Female ; Gene Frequency ; Genes ; Genotype ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Minisatellite Repeats ; Pathogenesis ; PCR ; polymerase chain reaction ; Polymorphism, Genetic ; Population ; Rheumatism ; Rheumatoid arthritis ; Rheumatoid Factor - analysis ; Spain - ethnology ; Studies ; TGF ; transforming growth factor ; United States ; White people</subject><ispartof>Annals of the rheumatic diseases, 2007-01, Vol.66 (1), p.118-120</ispartof><rights>Copyright 2007 by Annals of the Rheumatic Diseases</rights><rights>2007 INIST-CNRS</rights><rights>Copyright: 2007 Copyright 2007 by Annals of the Rheumatic Diseases</rights><rights>Copyright © 2007 BMJ Publishing Group and European League Against Rheumatism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b648t-620048bfe8697a5a9539e3fbf4002477c6c527d302b9cf9359157c199cd7411d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/66/1/118.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/66/1/118.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,727,780,784,885,3196,23571,27924,27925,53791,53793,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18336111$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16707531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres, B</creatorcontrib><creatorcontrib>Orozco, G</creatorcontrib><creatorcontrib>García-Lozano, J R</creatorcontrib><creatorcontrib>Oliver, J</creatorcontrib><creatorcontrib>Fernández, O</creatorcontrib><creatorcontrib>González-Gay, M A</creatorcontrib><creatorcontrib>Balsa, A</creatorcontrib><creatorcontrib>García, A</creatorcontrib><creatorcontrib>Pascual-Salcedo, D</creatorcontrib><creatorcontrib>López-Nevot, M A</creatorcontrib><creatorcontrib>Núñez-Roldán, A</creatorcontrib><creatorcontrib>Martín, J</creatorcontrib><creatorcontrib>González-Escribano, M F</creatorcontrib><title>Asporin repeat polymorphism in rheumatoid arthritis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Background: Asporin belongs to a family of proteins associated with the cartilage matrix. Objective: To investigate the role of the functional polymorphism consisting of an aspartic acid (D) repeat polymorphism located in the ASPN gene in the susceptibility to and clinical outcome of rheumatoid arthritis. Methods: A total of 803 Spanish Caucasian patients with rheumatoid arthritis and 904 controls of the same ethnic origin and matched for age and sex were included in the study. The asporin D repeat polymorphism was genotyped using polymerase chain reaction with a fluorescent primer. Results: No significant differences were detected in the distribution of the 10 alleles found in our population on comparing patients with rheumatoid arthritis with control groups. Nevertheless, individuals bearing D14 produced rheumatoid factor more often than the rest (85.7% v 72.1%, p = 0.006, odds ratio (OR) = 2.35, 95% confidence interval 1.21 to 4.50), and the mean (SD) onset age was higher in the group of individuals bearing D13 (50.09 (13.94)) compared with the rest (47.21 (14.31)), although the difference did not reach significance (p = 0.06). Conclusion: The results do not support a major role for asporin D repeat polymorphism in the susceptibility to rheumatoid arthritis. Nevertheless, they support the influence of this gene on the outcome of the disease.</description><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>ASPN</subject><subject>asporin gene</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Concise Report</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>Diseases of the osteoarticular system</subject><subject>DNA</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix Proteins - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minisatellite Repeats</subject><subject>Pathogenesis</subject><subject>PCR</subject><subject>polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>Population</subject><subject>Rheumatism</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid Factor - analysis</subject><subject>Spain - ethnology</subject><subject>Studies</subject><subject>TGF</subject><subject>transforming growth factor</subject><subject>United States</subject><subject>White people</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1v1DAQxS0EokvpuTe0EoIDUrae-PtSqVrxJVUFAe3VchyH9TaJUztB9L_HS1Yt9NKTZc_Pb97MQ-gY8AqA8BMT61WJMV9hxmjJn6AFUC6LEnP8FC0wxqSgiosD9CKlbb5iCfI5OgAusGAEFoicpSFE3y-jG5wZl0Nob7sQh41P3XL3vHFTZ8bg66WJ4yb60aeX6Flj2uSO9uchuvzw_sf6U3H-5ePn9dl5UXEqx4JnY1RWjZNcCcOMYkQ50lQNxbikQlhuWSlqgstK2UYRpoAJC0rZWlCAmhyi01l3mKrO1db1YzStHqLvTLzVwXj9f6X3G_0z_NIglKQlyQJv9wIx3Ewujbrzybq2Nb0LU9JcEsmIwI-CoBioEkQGXz8At2GKfd5CbiqEZMD-9j2ZKRtDStE1d54B611uOuemd7npObf849W_o97z-6Ay8GYPmGRN20TTW5_uOUkIB9hxxcz5NLrfd3UTrzUXRDB9cbXWUip-8f3rN00z_27mq277qMs_v8C7ew</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Torres, B</creator><creator>Orozco, G</creator><creator>García-Lozano, J R</creator><creator>Oliver, J</creator><creator>Fernández, O</creator><creator>González-Gay, M A</creator><creator>Balsa, A</creator><creator>García, A</creator><creator>Pascual-Salcedo, D</creator><creator>López-Nevot, M A</creator><creator>Núñez-Roldán, A</creator><creator>Martín, J</creator><creator>González-Escribano, M F</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070101</creationdate><title>Asporin repeat polymorphism in rheumatoid arthritis</title><author>Torres, B ; Orozco, G ; García-Lozano, J R ; Oliver, J ; Fernández, O ; González-Gay, M A ; Balsa, A ; García, A ; Pascual-Salcedo, D ; López-Nevot, M A ; Núñez-Roldán, A ; Martín, J ; González-Escribano, M F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b648t-620048bfe8697a5a9539e3fbf4002477c6c527d302b9cf9359157c199cd7411d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>ASPN</topic><topic>asporin gene</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Concise Report</topic><topic>Confidence intervals</topic><topic>Deoxyribonucleic acid</topic><topic>Disease</topic><topic>Diseases of the osteoarticular system</topic><topic>DNA</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix Proteins - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minisatellite Repeats</topic><topic>Pathogenesis</topic><topic>PCR</topic><topic>polymerase chain reaction</topic><topic>Polymorphism, Genetic</topic><topic>Population</topic><topic>Rheumatism</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid Factor - analysis</topic><topic>Spain - ethnology</topic><topic>Studies</topic><topic>TGF</topic><topic>transforming growth factor</topic><topic>United States</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres, B</creatorcontrib><creatorcontrib>Orozco, G</creatorcontrib><creatorcontrib>García-Lozano, J R</creatorcontrib><creatorcontrib>Oliver, J</creatorcontrib><creatorcontrib>Fernández, O</creatorcontrib><creatorcontrib>González-Gay, M A</creatorcontrib><creatorcontrib>Balsa, A</creatorcontrib><creatorcontrib>García, A</creatorcontrib><creatorcontrib>Pascual-Salcedo, D</creatorcontrib><creatorcontrib>López-Nevot, M A</creatorcontrib><creatorcontrib>Núñez-Roldán, A</creatorcontrib><creatorcontrib>Martín, J</creatorcontrib><creatorcontrib>González-Escribano, M F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres, B</au><au>Orozco, G</au><au>García-Lozano, J R</au><au>Oliver, J</au><au>Fernández, O</au><au>González-Gay, M A</au><au>Balsa, A</au><au>García, A</au><au>Pascual-Salcedo, D</au><au>López-Nevot, M A</au><au>Núñez-Roldán, A</au><au>Martín, J</au><au>González-Escribano, M F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asporin repeat polymorphism in rheumatoid arthritis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>66</volume><issue>1</issue><spage>118</spage><epage>120</epage><pages>118-120</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Background: Asporin belongs to a family of proteins associated with the cartilage matrix. Objective: To investigate the role of the functional polymorphism consisting of an aspartic acid (D) repeat polymorphism located in the ASPN gene in the susceptibility to and clinical outcome of rheumatoid arthritis. Methods: A total of 803 Spanish Caucasian patients with rheumatoid arthritis and 904 controls of the same ethnic origin and matched for age and sex were included in the study. The asporin D repeat polymorphism was genotyped using polymerase chain reaction with a fluorescent primer. Results: No significant differences were detected in the distribution of the 10 alleles found in our population on comparing patients with rheumatoid arthritis with control groups. Nevertheless, individuals bearing D14 produced rheumatoid factor more often than the rest (85.7% v 72.1%, p = 0.006, odds ratio (OR) = 2.35, 95% confidence interval 1.21 to 4.50), and the mean (SD) onset age was higher in the group of individuals bearing D13 (50.09 (13.94)) compared with the rest (47.21 (14.31)), although the difference did not reach significance (p = 0.06). Conclusion: The results do not support a major role for asporin D repeat polymorphism in the susceptibility to rheumatoid arthritis. Nevertheless, they support the influence of this gene on the outcome of the disease.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>16707531</pmid><doi>10.1136/ard.2006.055426</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Age of Onset Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - genetics ASPN asporin gene Biological and medical sciences Case-Control Studies Chi-Square Distribution Concise Report Confidence intervals Deoxyribonucleic acid Disease Diseases of the osteoarticular system DNA Extracellular matrix Extracellular Matrix Proteins - genetics Female Gene Frequency Genes Genotype Humans Inflammatory joint diseases Male Medical sciences Middle Aged Minisatellite Repeats Pathogenesis PCR polymerase chain reaction Polymorphism, Genetic Population Rheumatism Rheumatoid arthritis Rheumatoid Factor - analysis Spain - ethnology Studies TGF transforming growth factor United States White people |
| title | Asporin repeat polymorphism in rheumatoid arthritis |
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