Experience with experimental biological treatment and local gene therapy in Sjögren’s syndrome: implications for exocrine pathogenesis and treatment

Sjögren’s syndrome is an autoimmune exocrinopathy, mainly affecting the lacrimal and salivary glands, and resulting in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown, and only palliative treatment is currently available. Data o...

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Veröffentlicht in:	Annals of the rheumatic diseases 2006-11, Vol.65 (11), p.1406-1413
Hauptverfasser:	Lodde, B M, Baum, B J, Tak, P P, Illei, G
Format:	Artikel
Sprache:	eng
Schlagworte:	AAV adeno-associated virus Animals B cell-activating factor BAFF Biological and medical sciences Disease Models, Animal Diseases of the osteoarticular system Fas ligand FasL Gene Transfer Techniques Genetic Therapy - methods human 55-kDa TNF receptor extracellular domain linked to a mouse IgG heavy chain Humans IFN Immunologic Factors - therapeutic use interferon MALT Medical sciences mucosa-associated lymphoid tissue NFκB NOD non-obese diabetic normal T cell expressed and secreted nuclear factor κB rAAV2 RANTES recombinant serotype 2 AAV vector regulated on activation Review Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sjogren's Syndrome - immunology Sjogren's Syndrome - therapy SMG submandibular gland TNF TNFRp55-Ig tumour necrosis factor vasoactive intestinal peptide VIP
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