Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis
Background: Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment. Objectives: To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheum...
Gespeichert in:
| Veröffentlicht in: | Annals of the rheumatic diseases 2006-09, Vol.65 (9), p.1198-1201 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1201 |
|---|---|
| container_issue | 9 |
| container_start_page | 1198 |
| container_title | Annals of the rheumatic diseases |
| container_volume | 65 |
| creator | Otero, M Lago, R Gomez, R Lago, F Dieguez, C Gómez-Reino, J J Gualillo, O |
| description | Background: Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment. Objectives: To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheumatoid arthritis and to compare them with levels in healthy controls. Methods: Adiponectin, resistin, visfatin and leptin concentrations were measured in 31 patients with rheumatoid arthritis and 18 healthy controls by using specific enzyme-linked immunosorbent assays. Results: Patients with rheumatoid arthritis showed considerably higher plasma levels of leptin, adiponectin and visfatin than healthy controls. No marked difference was observed in resistin levels between patients and controls. Conclusion: A marked increase in plasma levels of leptin, adiponectin and visfatin was noted in patients with rheumatoid arthritis, whereas resistin levels were similar to those observed in healthy controls. Coordinated roles for adiponectin, leptin and visfatin are suggested in the modulation of the inflammatory environment in patients with rheumatoid arthritis, whereas the lack of modulation in resistin levels is predictive of an irrelevant role for this peptide, suggesting that resistin level is probably not one of the main signals associated with the pathogenesis of this disease. |
| doi_str_mv | 10.1136/ard.2005.046540 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1798289</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4008383091</sourcerecordid><originalsourceid>FETCH-LOGICAL-b553t-3b93678a164f824cac8d53b2e18646d98f85149f42d633b6b6a7e62622cb3e4b3</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEotvCmRuyhOCAyNZfsZ1LJbSFglRBhaAcrUniNF7ysdjJAkf-ObPNqgUuPc2M5pnxO55JkieMLhkT6hhCteSUZksqVSbpvWTBpDIpp4reTxaUUpHKXOmD5DDGNYbUMPMwOWBKMplrvkh-rxror1wkviebFmIHpHVb10Yy1KSGMa1c8FtXkWYI3dAjCJXfoFOOvn-F7ObaBhd9RI9AX5Gtj1iJwa4nOq4fI_nhx4aExk0djIOvCISxCX708VHyoIY2usd7e5R8efvm8-pdev7x7P3q9XlaZJkYU1HkQmkDKL02XJZQmioTBXfMKKmq3NQmw5lqySslRKEKBdoprjgvC-FkIY6Sk7nvZio6V5WoKkBrN8F3EH7ZAbz9N9P7xl4NW8t0brjJscGLfYMwfJ9cHG3nY-naFno3TNEqo4VQXN4JslwwhdtD8Nl_4HqYQo-_gI9qbaRW-Y46nqkyDDEGV99oZtTursDiFdjdFdj5CrDi6d-j3vL7tSPwfA9ALKGtA_Slj7ecoSjwmktnDpfrft7kIXyzSgud2Q-XK3t5IdXp2cUn-xX5lzNfdOs7Vf4B1ETZAw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777847696</pqid></control><display><type>article</type><title>Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Otero, M ; Lago, R ; Gomez, R ; Lago, F ; Dieguez, C ; Gómez-Reino, J J ; Gualillo, O</creator><creatorcontrib>Otero, M ; Lago, R ; Gomez, R ; Lago, F ; Dieguez, C ; Gómez-Reino, J J ; Gualillo, O</creatorcontrib><description>Background: Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment. Objectives: To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheumatoid arthritis and to compare them with levels in healthy controls. Methods: Adiponectin, resistin, visfatin and leptin concentrations were measured in 31 patients with rheumatoid arthritis and 18 healthy controls by using specific enzyme-linked immunosorbent assays. Results: Patients with rheumatoid arthritis showed considerably higher plasma levels of leptin, adiponectin and visfatin than healthy controls. No marked difference was observed in resistin levels between patients and controls. Conclusion: A marked increase in plasma levels of leptin, adiponectin and visfatin was noted in patients with rheumatoid arthritis, whereas resistin levels were similar to those observed in healthy controls. Coordinated roles for adiponectin, leptin and visfatin are suggested in the modulation of the inflammatory environment in patients with rheumatoid arthritis, whereas the lack of modulation in resistin levels is predictive of an irrelevant role for this peptide, suggesting that resistin level is probably not one of the main signals associated with the pathogenesis of this disease.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2005.046540</identifier><identifier>PMID: 16414972</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adiponectin - blood ; Adult ; Arthritis, Rheumatoid - blood ; Biological and medical sciences ; BMI ; body mass index ; C reactive protein ; C-Reactive Protein - analysis ; CRP ; Cytokines - blood ; Diseases of the osteoarticular system ; Extended Report ; Female ; Hormones ; Humans ; Inflammatory joint diseases ; Insulin resistance ; Leptin - blood ; Male ; Medical sciences ; Middle Aged ; Mortality ; Nicotinamide Phosphoribosyltransferase ; PBEP ; Peptide Hormones - blood ; Plasma ; pre-B cell colony-enhancing factor ; Resistin - blood ; Rheumatoid arthritis ; Rodents ; Studies ; TNF ; tumour necrosis factor ; WAT ; white adipose tissue</subject><ispartof>Annals of the rheumatic diseases, 2006-09, Vol.65 (9), p.1198-1201</ispartof><rights>Copyright 2006 by Annals of the Rheumatic Diseases</rights><rights>2006 INIST-CNRS</rights><rights>Copyright: 2006 Copyright 2006 by Annals of the Rheumatic Diseases</rights><rights>Copyright © 2006 BMJ Publishing Group Ltd & European League Against Rheumatism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b553t-3b93678a164f824cac8d53b2e18646d98f85149f42d633b6b6a7e62622cb3e4b3</citedby><cites>FETCH-LOGICAL-b553t-3b93678a164f824cac8d53b2e18646d98f85149f42d633b6b6a7e62622cb3e4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/65/9/1198.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/65/9/1198.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,723,776,780,881,3183,23550,27901,27902,53766,53768,77343,77374</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18016172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16414972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otero, M</creatorcontrib><creatorcontrib>Lago, R</creatorcontrib><creatorcontrib>Gomez, R</creatorcontrib><creatorcontrib>Lago, F</creatorcontrib><creatorcontrib>Dieguez, C</creatorcontrib><creatorcontrib>Gómez-Reino, J J</creatorcontrib><creatorcontrib>Gualillo, O</creatorcontrib><title>Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Background: Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment. Objectives: To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheumatoid arthritis and to compare them with levels in healthy controls. Methods: Adiponectin, resistin, visfatin and leptin concentrations were measured in 31 patients with rheumatoid arthritis and 18 healthy controls by using specific enzyme-linked immunosorbent assays. Results: Patients with rheumatoid arthritis showed considerably higher plasma levels of leptin, adiponectin and visfatin than healthy controls. No marked difference was observed in resistin levels between patients and controls. Conclusion: A marked increase in plasma levels of leptin, adiponectin and visfatin was noted in patients with rheumatoid arthritis, whereas resistin levels were similar to those observed in healthy controls. Coordinated roles for adiponectin, leptin and visfatin are suggested in the modulation of the inflammatory environment in patients with rheumatoid arthritis, whereas the lack of modulation in resistin levels is predictive of an irrelevant role for this peptide, suggesting that resistin level is probably not one of the main signals associated with the pathogenesis of this disease.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Biological and medical sciences</subject><subject>BMI</subject><subject>body mass index</subject><subject>C reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>CRP</subject><subject>Cytokines - blood</subject><subject>Diseases of the osteoarticular system</subject><subject>Extended Report</subject><subject>Female</subject><subject>Hormones</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Insulin resistance</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nicotinamide Phosphoribosyltransferase</subject><subject>PBEP</subject><subject>Peptide Hormones - blood</subject><subject>Plasma</subject><subject>pre-B cell colony-enhancing factor</subject><subject>Resistin - blood</subject><subject>Rheumatoid arthritis</subject><subject>Rodents</subject><subject>Studies</subject><subject>TNF</subject><subject>tumour necrosis factor</subject><subject>WAT</subject><subject>white adipose tissue</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1v1DAQhiMEotvCmRuyhOCAyNZfsZ1LJbSFglRBhaAcrUniNF7ysdjJAkf-ObPNqgUuPc2M5pnxO55JkieMLhkT6hhCteSUZksqVSbpvWTBpDIpp4reTxaUUpHKXOmD5DDGNYbUMPMwOWBKMplrvkh-rxror1wkviebFmIHpHVb10Yy1KSGMa1c8FtXkWYI3dAjCJXfoFOOvn-F7ObaBhd9RI9AX5Gtj1iJwa4nOq4fI_nhx4aExk0djIOvCISxCX708VHyoIY2usd7e5R8efvm8-pdev7x7P3q9XlaZJkYU1HkQmkDKL02XJZQmioTBXfMKKmq3NQmw5lqySslRKEKBdoprjgvC-FkIY6Sk7nvZio6V5WoKkBrN8F3EH7ZAbz9N9P7xl4NW8t0brjJscGLfYMwfJ9cHG3nY-naFno3TNEqo4VQXN4JslwwhdtD8Nl_4HqYQo-_gI9qbaRW-Y46nqkyDDEGV99oZtTursDiFdjdFdj5CrDi6d-j3vL7tSPwfA9ALKGtA_Slj7ecoSjwmktnDpfrft7kIXyzSgud2Q-XK3t5IdXp2cUn-xX5lzNfdOs7Vf4B1ETZAw</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Otero, M</creator><creator>Lago, R</creator><creator>Gomez, R</creator><creator>Lago, F</creator><creator>Dieguez, C</creator><creator>Gómez-Reino, J J</creator><creator>Gualillo, O</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ</general><general>Elsevier Limited</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060901</creationdate><title>Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis</title><author>Otero, M ; Lago, R ; Gomez, R ; Lago, F ; Dieguez, C ; Gómez-Reino, J J ; Gualillo, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b553t-3b93678a164f824cac8d53b2e18646d98f85149f42d633b6b6a7e62622cb3e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Biological and medical sciences</topic><topic>BMI</topic><topic>body mass index</topic><topic>C reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>CRP</topic><topic>Cytokines - blood</topic><topic>Diseases of the osteoarticular system</topic><topic>Extended Report</topic><topic>Female</topic><topic>Hormones</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Insulin resistance</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nicotinamide Phosphoribosyltransferase</topic><topic>PBEP</topic><topic>Peptide Hormones - blood</topic><topic>Plasma</topic><topic>pre-B cell colony-enhancing factor</topic><topic>Resistin - blood</topic><topic>Rheumatoid arthritis</topic><topic>Rodents</topic><topic>Studies</topic><topic>TNF</topic><topic>tumour necrosis factor</topic><topic>WAT</topic><topic>white adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otero, M</creatorcontrib><creatorcontrib>Lago, R</creatorcontrib><creatorcontrib>Gomez, R</creatorcontrib><creatorcontrib>Lago, F</creatorcontrib><creatorcontrib>Dieguez, C</creatorcontrib><creatorcontrib>Gómez-Reino, J J</creatorcontrib><creatorcontrib>Gualillo, O</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otero, M</au><au>Lago, R</au><au>Gomez, R</au><au>Lago, F</au><au>Dieguez, C</au><au>Gómez-Reino, J J</au><au>Gualillo, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>65</volume><issue>9</issue><spage>1198</spage><epage>1201</epage><pages>1198-1201</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Background: Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment. Objectives: To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheumatoid arthritis and to compare them with levels in healthy controls. Methods: Adiponectin, resistin, visfatin and leptin concentrations were measured in 31 patients with rheumatoid arthritis and 18 healthy controls by using specific enzyme-linked immunosorbent assays. Results: Patients with rheumatoid arthritis showed considerably higher plasma levels of leptin, adiponectin and visfatin than healthy controls. No marked difference was observed in resistin levels between patients and controls. Conclusion: A marked increase in plasma levels of leptin, adiponectin and visfatin was noted in patients with rheumatoid arthritis, whereas resistin levels were similar to those observed in healthy controls. Coordinated roles for adiponectin, leptin and visfatin are suggested in the modulation of the inflammatory environment in patients with rheumatoid arthritis, whereas the lack of modulation in resistin levels is predictive of an irrelevant role for this peptide, suggesting that resistin level is probably not one of the main signals associated with the pathogenesis of this disease.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>16414972</pmid><doi>10.1136/ard.2005.046540</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4967 |
| ispartof | Annals of the rheumatic diseases, 2006-09, Vol.65 (9), p.1198-1201 |
| issn | 0003-4967 1468-2060 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1798289 |
| source | MEDLINE; BMJ Journals - NESLi2; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adiponectin - blood Adult Arthritis, Rheumatoid - blood Biological and medical sciences BMI body mass index C reactive protein C-Reactive Protein - analysis CRP Cytokines - blood Diseases of the osteoarticular system Extended Report Female Hormones Humans Inflammatory joint diseases Insulin resistance Leptin - blood Male Medical sciences Middle Aged Mortality Nicotinamide Phosphoribosyltransferase PBEP Peptide Hormones - blood Plasma pre-B cell colony-enhancing factor Resistin - blood Rheumatoid arthritis Rodents Studies TNF tumour necrosis factor WAT white adipose tissue |
| title | Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T04%3A21%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20plasma%20levels%20of%20fat-derived%20hormones%20adiponectin,%20leptin,%20resistin%20and%20visfatin%20in%20patients%20with%20rheumatoid%20arthritis&rft.jtitle=Annals%20of%20the%20rheumatic%20diseases&rft.au=Otero,%20M&rft.date=2006-09-01&rft.volume=65&rft.issue=9&rft.spage=1198&rft.epage=1201&rft.pages=1198-1201&rft.issn=0003-4967&rft.eissn=1468-2060&rft.coden=ARDIAO&rft_id=info:doi/10.1136/ard.2005.046540&rft_dat=%3Cproquest_pubme%3E4008383091%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1777847696&rft_id=info:pmid/16414972&rfr_iscdi=true |