B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-αGAL–producing B-1 cells

B-1b cells produce IgM natural antibodies against α1-3Galβ1-4GlcNAc (αGal). These can be tolerized by nonmyeloablative induction of mixed chimerism using αGal-positive (αGal+) donor marrow. We assessed the role of CR1/2 in this model for induction of tolerance of B-1b cells. Mixed hematopoietic chim...

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Veröffentlicht in:	Blood 2007-02, Vol.109 (4), p.1773-1781
Hauptverfasser:	Shimizu, Ichiro, Kawahara, Toshiyasu, Haspot, Fabienne, Bardwell, Philip D., Carroll, Michael C., Sykes, Megan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Hematologic and hematopoietic diseases Medical sciences Transplantation
Online-Zugang:	Volltext
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