Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations
Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. Th...
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Veröffentlicht in: | Archives of disease in childhood 1990-07, Vol.65 (7), p.768-770 |
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description | Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants. |
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Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.65.7.768</identifier><identifier>PMID: 2386383</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Child ; Child, Preschool ; Endotoxins ; Endotoxins - immunology ; Enzyme-Linked Immunosorbent Assay ; Glycolipids - immunology ; Humans ; Immunoglobulin G ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Immunoglobulins ; Infant ; Infant, Newborn ; Infant, Premature ; Infants ; Lipopolysaccharides ; Lipopolysaccharides - analysis ; Lipopolysaccharides - immunology ; Pediatrics ; Septicemia</subject><ispartof>Archives of disease in childhood, 1990-07, Vol.65 (7), p.768-770</ispartof><rights>Copyright BMJ Publishing Group LTD Jul 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</citedby><cites>FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1792452/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1792452/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2386383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, S K</creatorcontrib><creatorcontrib>Parton, J</creatorcontrib><creatorcontrib>Shortland, G</creatorcontrib><creatorcontrib>Stark, J M</creatorcontrib><creatorcontrib>Thompson, E N</creatorcontrib><title>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endotoxins</subject><subject>Endotoxins - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Glycolipids - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - analysis</subject><subject>Lipopolysaccharides - immunology</subject><subject>Pediatrics</subject><subject>Septicemia</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUuLFDEUhYMoYzu6cysUCLqx2rwqSbkQtFFHHFQYdTGbkKRSPWnzaJMqmfn3Rqpp1IVkceGej5NzOQA8RHCNEGHP1WDWrFvzNWfiFlghykSLIaW3wQpCSNpeCHEX3CtlByHCQpATcIKJYESQFbi8sHkOjQthjmnrk569i6WZUmPjkKZ07WJjUrbN1t-Y5N3eDS8aWyalvStXwcapSWMTUw7KVzCauslqcimW--DOqHyxDw7zFHx9--bL5qw9__Tu_ebVeasp51NL9TBCw1WPRjIagzWmrOsohAzjoa6Gvmd0gMqMTGshoEGss-NAtKWak86SU_By8d3POthhSeDlPrug8o1Mysm_leiu5Db9lIj3mHa4Gjw5GOT0Y67HyeCKsd6raNNcJO97SjoGK_j4H3CX5hzrcZJALuojtK_Us4UyOZWS7XiMgqD83ZisjUnWSS5rYxV_9Gf8I3yoqOrtorsy2eujrPJ3yTjhnfz4bSPR5vVnePnhTF5U_unC67D7_8-_AM2EsKg</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Jackson, S K</creator><creator>Parton, J</creator><creator>Shortland, G</creator><creator>Stark, J M</creator><creator>Thompson, E N</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900701</creationdate><title>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</title><author>Jackson, S K ; Parton, J ; Shortland, G ; Stark, J M ; Thompson, E N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endotoxins</topic><topic>Endotoxins - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Glycolipids - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - analysis</topic><topic>Lipopolysaccharides - immunology</topic><topic>Pediatrics</topic><topic>Septicemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, S K</creatorcontrib><creatorcontrib>Parton, J</creatorcontrib><creatorcontrib>Shortland, G</creatorcontrib><creatorcontrib>Stark, J M</creatorcontrib><creatorcontrib>Thompson, E N</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database (ProQuest)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, S K</au><au>Parton, J</au><au>Shortland, G</au><au>Stark, J M</au><au>Thompson, E N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>65</volume><issue>7</issue><spage>768</spage><epage>770</epage><pages>768-770</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><abstract>Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>2386383</pmid><doi>10.1136/adc.65.7.768</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Child Child, Preschool Endotoxins Endotoxins - immunology Enzyme-Linked Immunosorbent Assay Glycolipids - immunology Humans Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M - immunology Immunoglobulins Infant Infant, Newborn Infant, Premature Infants Lipopolysaccharides Lipopolysaccharides - analysis Lipopolysaccharides - immunology Pediatrics Septicemia |
title | Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations |
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