Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations

Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. Th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Archives of disease in childhood 1990-07, Vol.65 (7), p.768-770
Hauptverfasser: Jackson, S K, Parton, J, Shortland, G, Stark, J M, Thompson, E N
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 770
container_issue 7
container_start_page 768
container_title Archives of disease in childhood
container_volume 65
creator Jackson, S K
Parton, J
Shortland, G
Stark, J M
Thompson, E N
description Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.
doi_str_mv 10.1136/adc.65.7.768
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1792452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79943560</sourcerecordid><originalsourceid>FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</originalsourceid><addsrcrecordid>eNp9kUuLFDEUhYMoYzu6cysUCLqx2rwqSbkQtFFHHFQYdTGbkKRSPWnzaJMqmfn3Rqpp1IVkceGej5NzOQA8RHCNEGHP1WDWrFvzNWfiFlghykSLIaW3wQpCSNpeCHEX3CtlByHCQpATcIKJYESQFbi8sHkOjQthjmnrk569i6WZUmPjkKZ07WJjUrbN1t-Y5N3eDS8aWyalvStXwcapSWMTUw7KVzCauslqcimW--DOqHyxDw7zFHx9--bL5qw9__Tu_ebVeasp51NL9TBCw1WPRjIagzWmrOsohAzjoa6Gvmd0gMqMTGshoEGss-NAtKWak86SU_By8d3POthhSeDlPrug8o1Mysm_leiu5Db9lIj3mHa4Gjw5GOT0Y67HyeCKsd6raNNcJO97SjoGK_j4H3CX5hzrcZJALuojtK_Us4UyOZWS7XiMgqD83ZisjUnWSS5rYxV_9Gf8I3yoqOrtorsy2eujrPJ3yTjhnfz4bSPR5vVnePnhTF5U_unC67D7_8-_AM2EsKg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3078787349</pqid></control><display><type>article</type><title>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Jackson, S K ; Parton, J ; Shortland, G ; Stark, J M ; Thompson, E N</creator><creatorcontrib>Jackson, S K ; Parton, J ; Shortland, G ; Stark, J M ; Thompson, E N</creatorcontrib><description>Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.65.7.768</identifier><identifier>PMID: 2386383</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Child ; Child, Preschool ; Endotoxins ; Endotoxins - immunology ; Enzyme-Linked Immunosorbent Assay ; Glycolipids - immunology ; Humans ; Immunoglobulin G ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Immunoglobulins ; Infant ; Infant, Newborn ; Infant, Premature ; Infants ; Lipopolysaccharides ; Lipopolysaccharides - analysis ; Lipopolysaccharides - immunology ; Pediatrics ; Septicemia</subject><ispartof>Archives of disease in childhood, 1990-07, Vol.65 (7), p.768-770</ispartof><rights>Copyright BMJ Publishing Group LTD Jul 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</citedby><cites>FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1792452/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1792452/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2386383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, S K</creatorcontrib><creatorcontrib>Parton, J</creatorcontrib><creatorcontrib>Shortland, G</creatorcontrib><creatorcontrib>Stark, J M</creatorcontrib><creatorcontrib>Thompson, E N</creatorcontrib><title>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endotoxins</subject><subject>Endotoxins - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Glycolipids - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - analysis</subject><subject>Lipopolysaccharides - immunology</subject><subject>Pediatrics</subject><subject>Septicemia</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUuLFDEUhYMoYzu6cysUCLqx2rwqSbkQtFFHHFQYdTGbkKRSPWnzaJMqmfn3Rqpp1IVkceGej5NzOQA8RHCNEGHP1WDWrFvzNWfiFlghykSLIaW3wQpCSNpeCHEX3CtlByHCQpATcIKJYESQFbi8sHkOjQthjmnrk569i6WZUmPjkKZ07WJjUrbN1t-Y5N3eDS8aWyalvStXwcapSWMTUw7KVzCauslqcimW--DOqHyxDw7zFHx9--bL5qw9__Tu_ebVeasp51NL9TBCw1WPRjIagzWmrOsohAzjoa6Gvmd0gMqMTGshoEGss-NAtKWak86SU_By8d3POthhSeDlPrug8o1Mysm_leiu5Db9lIj3mHa4Gjw5GOT0Y67HyeCKsd6raNNcJO97SjoGK_j4H3CX5hzrcZJALuojtK_Us4UyOZWS7XiMgqD83ZisjUnWSS5rYxV_9Gf8I3yoqOrtorsy2eujrPJ3yTjhnfz4bSPR5vVnePnhTF5U_unC67D7_8-_AM2EsKg</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Jackson, S K</creator><creator>Parton, J</creator><creator>Shortland, G</creator><creator>Stark, J M</creator><creator>Thompson, E N</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900701</creationdate><title>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</title><author>Jackson, S K ; Parton, J ; Shortland, G ; Stark, J M ; Thompson, E N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b477t-4bdf0c7a91f3fcc2b24655400622df3fd9964d0acf6bb880c165efd3be4b735e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endotoxins</topic><topic>Endotoxins - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Glycolipids - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - analysis</topic><topic>Lipopolysaccharides - immunology</topic><topic>Pediatrics</topic><topic>Septicemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, S K</creatorcontrib><creatorcontrib>Parton, J</creatorcontrib><creatorcontrib>Shortland, G</creatorcontrib><creatorcontrib>Stark, J M</creatorcontrib><creatorcontrib>Thompson, E N</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database (ProQuest)</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, S K</au><au>Parton, J</au><au>Shortland, G</au><au>Stark, J M</au><au>Thompson, E N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>65</volume><issue>7</issue><spage>768</spage><epage>770</epage><pages>768-770</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><abstract>Serum antibody to lipopolysaccharide core glycolipid was measured in normal children and in full term and premature (less than or equal to 1500 g) infants. Antilipopolysaccharide core glycolipid antibody was present in term infants and normal children, and reached adult titres by 15 years of age. The specific anti core glycolipid antibody was predominately of the IgG class. Preterm infants (less than 32 weeks' gestation) had significantly lower titres of antilipopolysaccharide core glycolipid than more mature preterm or term infants. The results suggest that administration of anticore glycolipid immunoglobulin may be beneficial in the treatment or prevention of Gram negative septicaemia in preterm and very young infants.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>2386383</pmid><doi>10.1136/adc.65.7.768</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0003-9888
ispartof Archives of disease in childhood, 1990-07, Vol.65 (7), p.768-770
issn 0003-9888
1468-2044
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1792452
source MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection
subjects Adolescent
Child
Child, Preschool
Endotoxins
Endotoxins - immunology
Enzyme-Linked Immunosorbent Assay
Glycolipids - immunology
Humans
Immunoglobulin G
Immunoglobulin G - immunology
Immunoglobulin M - immunology
Immunoglobulins
Infant
Infant, Newborn
Infant, Premature
Infants
Lipopolysaccharides
Lipopolysaccharides - analysis
Lipopolysaccharides - immunology
Pediatrics
Septicemia
title Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T06%3A02%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20immunoglobulins%20to%20endotoxin%20core%20glycolipid:%20establishment%20of%20normal%20concentrations&rft.jtitle=Archives%20of%20disease%20in%20childhood&rft.au=Jackson,%20S%20K&rft.date=1990-07-01&rft.volume=65&rft.issue=7&rft.spage=768&rft.epage=770&rft.pages=768-770&rft.issn=0003-9888&rft.eissn=1468-2044&rft_id=info:doi/10.1136/adc.65.7.768&rft_dat=%3Cproquest_pubme%3E79943560%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3078787349&rft_id=info:pmid/2386383&rfr_iscdi=true