Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma
Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics no...
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| Veröffentlicht in: | BMJ 1972-03, Vol.1 (5800), p.585-590 |
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| creator | Brown, H. Morrow Storey, G. George, W. H. S. |
| description | Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known. |
| doi_str_mv | 10.1136/bmj.1.5800.585 |
| format | Article |
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Morrow ; Storey, G. ; George, W. H. S.</creator><creatorcontrib>Brown, H. Morrow ; Storey, G. ; George, W. H. S.</creatorcontrib><description>Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.1.5800.585</identifier><identifier>PMID: 4335298</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adolescent ; Adrenal Glands - drug effects ; Adrenocorticotropic Hormone - therapeutic use ; Adult ; Aerosols ; Aged ; Allergens ; Allergies ; Asthma ; Asthma - drug therapy ; Betamethasone - therapeutic use ; Child ; Dosage ; Female ; Humans ; Hydrocortisone - blood ; Infections ; Male ; Middle Aged ; Papers and Originals ; Prednisolone - therapeutic use ; Pregnanetriol - administration & dosage ; Pregnanetriol - metabolism ; Side effects ; Steroid therapy ; Steroids ; Substance Withdrawal Syndrome ; Substance-Related Disorders ; Withdrawal symptoms</subject><ispartof>BMJ, 1972-03, Vol.1 (5800), p.585-590</ispartof><rights>Copyright 1972 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Mar 4, 1972</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-6adf94079bd6f1aa93ed5559e2efe19f6177700f0ac915b6df9b77a6325237e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25417899$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25417899$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4335298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, H. Morrow</creatorcontrib><creatorcontrib>Storey, G.</creatorcontrib><creatorcontrib>George, W. H. S.</creatorcontrib><title>Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma</title><title>BMJ</title><addtitle>Br Med J</addtitle><description>Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known.</description><subject>Adolescent</subject><subject>Adrenal Glands - drug effects</subject><subject>Adrenocorticotropic Hormone - therapeutic use</subject><subject>Adult</subject><subject>Aerosols</subject><subject>Aged</subject><subject>Allergens</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>Betamethasone - therapeutic use</subject><subject>Child</subject><subject>Dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Infections</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Papers and Originals</subject><subject>Prednisolone - therapeutic use</subject><subject>Pregnanetriol - administration & dosage</subject><subject>Pregnanetriol - metabolism</subject><subject>Side effects</subject><subject>Steroid therapy</subject><subject>Steroids</subject><subject>Substance Withdrawal Syndrome</subject><subject>Substance-Related Disorders</subject><subject>Withdrawal symptoms</subject><issn>0007-1447</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1vEzEQxS0EKlHplRuSJU4cNtjrrzUHpE1oAakqqlooN8u7O2427K6D7RT473GUKMCJy4ys9_P4eR5CzymZU8rk62Zcz-lcVITkIh6hGeWyKkTF2GM0I4SognKunqKzGNf5WDJVaclP0AlnTJS6mqG7BbSDHyGtbPQT4Hf9JvhN7yeb4A2u8RX8wDcJgu87XOcW_YCdDzitAN8GsGmEKWHvcD0MEO77FtcxrUb7DD1xdohwduin6PPF-e3yQ3H56f3HZX1ZNIKoVEjbOc2J0k0nHbVWM-iEEBpKcEC1k1QpRYgjttVUNDLTjVJWslLkzwBlp-jtfu5m24zQtdlNsIPZhH604Zfxtjf_KlO_Mvf-wVBVKSF5HvDyMCD471uIyaz9NkzZc0aULGXJCcnUfE-1eQUxgDu-QInZRWFyFIaaXRS5iHzhxd--jvhh8X_0dUw-HOVS8GxM66wXe72PCX4edRu-GamYEubqy9JUXy8W6u56YWTmX-35nY__ePsN4jqqyA</recordid><startdate>19720304</startdate><enddate>19720304</enddate><creator>Brown, H. 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Morrow</au><au>Storey, G.</au><au>George, W. H. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J</addtitle><date>1972-03-04</date><risdate>1972</risdate><volume>1</volume><issue>5800</issue><spage>585</spage><epage>590</epage><pages>585-590</pages><issn>0007-1447</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>4335298</pmid><doi>10.1136/bmj.1.5800.585</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | Adolescent Adrenal Glands - drug effects Adrenocorticotropic Hormone - therapeutic use Adult Aerosols Aged Allergens Allergies Asthma Asthma - drug therapy Betamethasone - therapeutic use Child Dosage Female Humans Hydrocortisone - blood Infections Male Middle Aged Papers and Originals Prednisolone - therapeutic use Pregnanetriol - administration & dosage Pregnanetriol - metabolism Side effects Steroid therapy Steroids Substance Withdrawal Syndrome Substance-Related Disorders Withdrawal symptoms |
| title | Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma |
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