Vagotomy without Diarrhoea
The incidence of diarrhoea after three types of vagotomy was assessed “blind” at a gastric follow-up clinic one year after operation. Diarrhoea was recorded in 24% of patients after truncal vagotomy and pyloroplasty, in 18% after selective vagotomy and pyloroplasty, but in only 2% of patients after...
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| Veröffentlicht in: | BMJ 1972-09, Vol.3 (5830), p.788-790 |
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| creator | Johnston, D. Humphrey, C. S. Walker, B. E. Pulvertaft, C. N. Goligher, J. C. |
| description | The incidence of diarrhoea after three types of vagotomy was assessed “blind” at a gastric follow-up clinic one year after operation. Diarrhoea was recorded in 24% of patients after truncal vagotomy and pyloroplasty, in 18% after selective vagotomy and pyloroplasty, but in only 2% of patients after highly selective vagotomy without a drainage procedure. The incidence of diarrhoea was significantly less (P < 0·01) after highly selective vagotomy than after either of the other procedures. Hypertonic glucose solution given by mouth to 15 representative patients from each group and to 15 patients before operation provoked the onset of diarrhoea in 67% of the patients who had undergone truncal vagotomy and pyloroplasty, in 60% of those who had undergone selective vagotomy and pyloroplasty, in 13% of those who had undergone highly selective vagotomy without a drainage procedure, and in none of the preoperative patients. Again the difference between the “highly selective” group and the other two groups of vagotomized patients was statistically significant. It is suggested that postvagotomy diarrhoea is attributable both to unregulated gastric emptying after truncal or selective vagotomy with a drainage procedure and to the extragastric denervation produced by truncal vagotomy. “Postvagotomy” diarrhoea can be virtually eliminated by using highly selective vagotomy without a drainage procedure. |
| doi_str_mv | 10.1136/bmj.3.5830.788 |
| format | Article |
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S. ; Walker, B. E. ; Pulvertaft, C. N. ; Goligher, J. C.</creator><creatorcontrib>Johnston, D. ; Humphrey, C. S. ; Walker, B. E. ; Pulvertaft, C. N. ; Goligher, J. C.</creatorcontrib><description>The incidence of diarrhoea after three types of vagotomy was assessed “blind” at a gastric follow-up clinic one year after operation. Diarrhoea was recorded in 24% of patients after truncal vagotomy and pyloroplasty, in 18% after selective vagotomy and pyloroplasty, but in only 2% of patients after highly selective vagotomy without a drainage procedure. The incidence of diarrhoea was significantly less (P < 0·01) after highly selective vagotomy than after either of the other procedures. Hypertonic glucose solution given by mouth to 15 representative patients from each group and to 15 patients before operation provoked the onset of diarrhoea in 67% of the patients who had undergone truncal vagotomy and pyloroplasty, in 60% of those who had undergone selective vagotomy and pyloroplasty, in 13% of those who had undergone highly selective vagotomy without a drainage procedure, and in none of the preoperative patients. Again the difference between the “highly selective” group and the other two groups of vagotomized patients was statistically significant. It is suggested that postvagotomy diarrhoea is attributable both to unregulated gastric emptying after truncal or selective vagotomy with a drainage procedure and to the extragastric denervation produced by truncal vagotomy. “Postvagotomy” diarrhoea can be virtually eliminated by using highly selective vagotomy without a drainage procedure.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.3.5830.788</identifier><identifier>PMID: 5076248</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Diarrhea ; Diarrhea - epidemiology ; Diarrhea - etiology ; Duodenal ulcer ; Duodenal Ulcer - surgery ; Follow-Up Studies ; Gastric emptying ; Gastrointestinal Motility ; Glucose ; Humans ; Hypertonic Solutions ; Methods ; Nerves ; Papers and Originals ; Proximal gastric vagotomy ; Pylorus - surgery ; Statistical results ; Surgical specialties ; Test meals ; Truncal vagotomy ; Vagotomy ; Vagotomy - adverse effects</subject><ispartof>BMJ, 1972-09, Vol.3 (5830), p.788-790</ispartof><rights>Copyright 1972 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Sep 30, 1972</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-2543b5bff78b641f70b82b6e9ac32df9755dcaa8ce2a9ac80ae81269243da63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25420244$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25420244$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,725,778,782,801,883,27911,27912,53778,53780,58004,58237</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5076248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnston, D.</creatorcontrib><creatorcontrib>Humphrey, C. S.</creatorcontrib><creatorcontrib>Walker, B. E.</creatorcontrib><creatorcontrib>Pulvertaft, C. N.</creatorcontrib><creatorcontrib>Goligher, J. C.</creatorcontrib><title>Vagotomy without Diarrhoea</title><title>BMJ</title><addtitle>Br Med J</addtitle><description>The incidence of diarrhoea after three types of vagotomy was assessed “blind” at a gastric follow-up clinic one year after operation. Diarrhoea was recorded in 24% of patients after truncal vagotomy and pyloroplasty, in 18% after selective vagotomy and pyloroplasty, but in only 2% of patients after highly selective vagotomy without a drainage procedure. The incidence of diarrhoea was significantly less (P < 0·01) after highly selective vagotomy than after either of the other procedures. Hypertonic glucose solution given by mouth to 15 representative patients from each group and to 15 patients before operation provoked the onset of diarrhoea in 67% of the patients who had undergone truncal vagotomy and pyloroplasty, in 60% of those who had undergone selective vagotomy and pyloroplasty, in 13% of those who had undergone highly selective vagotomy without a drainage procedure, and in none of the preoperative patients. Again the difference between the “highly selective” group and the other two groups of vagotomized patients was statistically significant. It is suggested that postvagotomy diarrhoea is attributable both to unregulated gastric emptying after truncal or selective vagotomy with a drainage procedure and to the extragastric denervation produced by truncal vagotomy. “Postvagotomy” diarrhoea can be virtually eliminated by using highly selective vagotomy without a drainage procedure.</description><subject>Diarrhea</subject><subject>Diarrhea - epidemiology</subject><subject>Diarrhea - etiology</subject><subject>Duodenal ulcer</subject><subject>Duodenal Ulcer - surgery</subject><subject>Follow-Up Studies</subject><subject>Gastric emptying</subject><subject>Gastrointestinal Motility</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hypertonic Solutions</subject><subject>Methods</subject><subject>Nerves</subject><subject>Papers and Originals</subject><subject>Proximal gastric vagotomy</subject><subject>Pylorus - surgery</subject><subject>Statistical results</subject><subject>Surgical specialties</subject><subject>Test meals</subject><subject>Truncal vagotomy</subject><subject>Vagotomy</subject><subject>Vagotomy - adverse effects</subject><issn>0007-1447</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkM1LwzAYxoMoc8xdPQjCQBA8tOarSXoRdH5CnQdl15C26da5LjNp1f33pmzMj4un8OZ53h_P-wBwiGCIEGHnaTULSRgJAkMuxA7oIspE4GeyC7oQQh4gSvk-6Ds38yMmXMSMdkAngpxhKrrgaKwmpjbVavBR1lPT1IPrUlk7NVodgL1CzZ3ub94eeL69eRneB8nT3cPwMglST6kDHFGSRmlRcJEyigoOU4FTpmOVEZwXMY-iPFNKZBor_yeg0gJhFmNKcsVID1ysqcsmrXSe6UVt1VwubVkpu5JGlfK3siincmLeJeKCEQw94HQDsOat0a6WVekyPZ-rhTaNkwIxSCJIvfHkj3FmGrvwp3kWZzCOKWtx4dqVWeOc1cU2CoKyLV360iWRbenSl-4Xjn8esLVvKv7WZ642div72jDEtI0VrPXS1fpzqyv7KhknPJKj8VAmkIyuRo-JbAOerf1tjn-yfQGGfaIE</recordid><startdate>19720930</startdate><enddate>19720930</enddate><creator>Johnston, D.</creator><creator>Humphrey, C. S.</creator><creator>Walker, B. E.</creator><creator>Pulvertaft, C. N.</creator><creator>Goligher, J. 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C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-2543b5bff78b641f70b82b6e9ac32df9755dcaa8ce2a9ac80ae81269243da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Diarrhea</topic><topic>Diarrhea - epidemiology</topic><topic>Diarrhea - etiology</topic><topic>Duodenal ulcer</topic><topic>Duodenal Ulcer - surgery</topic><topic>Follow-Up Studies</topic><topic>Gastric emptying</topic><topic>Gastrointestinal Motility</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hypertonic Solutions</topic><topic>Methods</topic><topic>Nerves</topic><topic>Papers and Originals</topic><topic>Proximal gastric vagotomy</topic><topic>Pylorus - surgery</topic><topic>Statistical results</topic><topic>Surgical specialties</topic><topic>Test meals</topic><topic>Truncal vagotomy</topic><topic>Vagotomy</topic><topic>Vagotomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnston, D.</creatorcontrib><creatorcontrib>Humphrey, C. 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S.</au><au>Walker, B. E.</au><au>Pulvertaft, C. N.</au><au>Goligher, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vagotomy without Diarrhoea</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J</addtitle><date>1972-09-30</date><risdate>1972</risdate><volume>3</volume><issue>5830</issue><spage>788</spage><epage>790</epage><pages>788-790</pages><issn>0007-1447</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>The incidence of diarrhoea after three types of vagotomy was assessed “blind” at a gastric follow-up clinic one year after operation. Diarrhoea was recorded in 24% of patients after truncal vagotomy and pyloroplasty, in 18% after selective vagotomy and pyloroplasty, but in only 2% of patients after highly selective vagotomy without a drainage procedure. The incidence of diarrhoea was significantly less (P < 0·01) after highly selective vagotomy than after either of the other procedures. Hypertonic glucose solution given by mouth to 15 representative patients from each group and to 15 patients before operation provoked the onset of diarrhoea in 67% of the patients who had undergone truncal vagotomy and pyloroplasty, in 60% of those who had undergone selective vagotomy and pyloroplasty, in 13% of those who had undergone highly selective vagotomy without a drainage procedure, and in none of the preoperative patients. Again the difference between the “highly selective” group and the other two groups of vagotomized patients was statistically significant. It is suggested that postvagotomy diarrhoea is attributable both to unregulated gastric emptying after truncal or selective vagotomy with a drainage procedure and to the extragastric denervation produced by truncal vagotomy. “Postvagotomy” diarrhoea can be virtually eliminated by using highly selective vagotomy without a drainage procedure.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>5076248</pmid><doi>10.1136/bmj.3.5830.788</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMJ, 1972-09, Vol.3 (5830), p.788-790 |
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| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Diarrhea Diarrhea - epidemiology Diarrhea - etiology Duodenal ulcer Duodenal Ulcer - surgery Follow-Up Studies Gastric emptying Gastrointestinal Motility Glucose Humans Hypertonic Solutions Methods Nerves Papers and Originals Proximal gastric vagotomy Pylorus - surgery Statistical results Surgical specialties Test meals Truncal vagotomy Vagotomy Vagotomy - adverse effects |
| title | Vagotomy without Diarrhoea |
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