Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

Phosphatidylinositol-3-kinase (PI3K), and its downstream effector Akt, or protein kinase Bα (PKBα), play a major regulatory role in control of apoptosis, proliferation, and angiogenesis. PI3K and Akt are amplified or overexpressed in a number of malignancies, including sarcomas, ovarian cancer, mult...

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Veröffentlicht in:	Blood 2007-01, Vol.109 (2), p.560-565
Hauptverfasser:	Arbiser, Jack L., Kau, Tweeny, Konar, Martha, Narra, Krishna, Ramchandran, Ramani, Summers, Scott A., Vlahos, Chris J., Ye, Keqiang, Perry, Betsy N., Matter, William, Fischl, Anthony, Cook, James, Silver, Pamela A., Bain, Jenny, Cohen, Philip, Whitmire, David, Furness, Scott, Govindarajan, Baskaran, Bowen, J. Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Alkaloids - pharmacology Animals Antineoplastic agents Ants Biological and medical sciences Cell Line Chemotherapy Embryo, Nonmammalian - blood supply Embryo, Nonmammalian - drug effects Endothelial Cells - drug effects Enzyme Activation - drug effects Hemostasis, Thrombosis, and Vascular Biology Medical sciences Mice Molecular Structure Neovascularization, Physiologic - drug effects Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinases - chemistry Protein Kinases - drug effects Protein Kinases - metabolism Signal Transduction - drug effects Zebrafish - embryology
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