Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

Polycomb group (PcG) protein Bmi-1 is an important regulator of cell proliferation. It regulates cellular senescence and proliferation of cells via the transcriptional repression of INK4a/ARF locus and other target genes. Here, we report that Mel-18, a PcG ring finger protein (PCGF) transcriptionall...

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Veröffentlicht in:	Molecular biology of the cell 2007-02, Vol.18 (2), p.536-546
Hauptverfasser:	Guo, Wei-Jian, Datta, Sonal, Band, Vimla, Dimri, Goberdhan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Proliferation Cells, Cultured Cellular Senescence - genetics Chromatin Immunoprecipitation Down-Regulation Gene Expression Regulation Genes, Reporter Humans Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Polycomb Repressive Complex 1 Promoter Regions, Genetic Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism RNA Interference
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