A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2

The active thyroid hormone, triiodothyronine (T3), regulates mitochondrial uncoupling protein activity and related thermogenesis in peripheral tissues. Type 2 deiodinase (DII), an enzyme that catalyzes active thyroid hormone production, and mitochondrial uncoupling protein 2 (UCP2) are also present...

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Veröffentlicht in:	Cell metabolism 2007, Vol.5 (1), p.21-33
Hauptverfasser:	Coppola, Anna, Liu, Zhong-Wu, Andrews, Zane B., Paradis, Eric, Roy, Marie-Claude, Friedman, Jeffrey M., Ricquier, Daniel, Richard, Denis, Horvath, Tamas L., Gao, Xiao-Bing, Diano, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti-Related Protein Animals Arcuate Nucleus of Hypothalamus - cytology Arcuate Nucleus of Hypothalamus - metabolism Eating Fasting Feeding Behavior Green Fluorescent Proteins Guanosine Diphosphate - metabolism Hypothalamus - cytology Intercellular Signaling Peptides and Proteins - metabolism Iodide Peroxidase - metabolism Iodothyronine Deiodinase Type II Ion Channels - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Mitochondrial Proteins - metabolism MOLNEURO Neuroglia - metabolism Neurons - metabolism Neuropeptide Y - metabolism Proto-Oncogene Proteins c-fos - metabolism Thermogenesis Triiodothyronine - metabolism Uncoupling Protein 2
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