Modulatory effect of prostaglandins on human monocyte activation for killing of high‐ and low‐virulence strains of Paracoccidioides brasiliensis
Summary The effect of indomethacin (Indo), a cyclo‐oxygenase inhibitor, on the monocyte‐mediated killing of a low‐ (Pb265) and a high‐ (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non‐activated or interferon‐γ (IFN‐γ) ‐activated huma...
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| Veröffentlicht in: | Immunology 2001-04, Vol.102 (4), p.480-485 |
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| creator | Soares, A. M. V. C. Calvi, S. A. Peraçoli, M. T. S. Fernandez, A. C. Dias, L. A. Dos Anjos, A. R. |
| description | Summary
The effect of indomethacin (Indo), a cyclo‐oxygenase inhibitor, on the monocyte‐mediated killing of a low‐ (Pb265) and a high‐ (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non‐activated or interferon‐γ (IFN‐γ) ‐activated human monocytes but these cells did show fungicidal activity if pretreated with Indo. In contrast with IFN‐γ, tumour necrosis factor‐α (TNF‐α) was very effective at stimulating the fungicidal activity of monocytes. While the low‐virulence strain, Pb265, could not be killed by monocytes, cells preincubated with IFN‐γ demonstrated fungicidal activity. The killing of this strain was also induced by pretreatment of monocytes with Indo. The results suggest a negative role for prostaglandins, which are synthesized via the cyclo‐oxygenase pathway, in the regulation of monocyte‐mediated killing of virulent and avirulent strains of P. brasiliensis and that TNF‐α generation during the fungus–monocyte interaction is more important in the killing of Pb265 than Pb18. |
| doi_str_mv | 10.1046/j.1365-2567.2001.01179.x |
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The effect of indomethacin (Indo), a cyclo‐oxygenase inhibitor, on the monocyte‐mediated killing of a low‐ (Pb265) and a high‐ (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non‐activated or interferon‐γ (IFN‐γ) ‐activated human monocytes but these cells did show fungicidal activity if pretreated with Indo. In contrast with IFN‐γ, tumour necrosis factor‐α (TNF‐α) was very effective at stimulating the fungicidal activity of monocytes. While the low‐virulence strain, Pb265, could not be killed by monocytes, cells preincubated with IFN‐γ demonstrated fungicidal activity. The killing of this strain was also induced by pretreatment of monocytes with Indo. The results suggest a negative role for prostaglandins, which are synthesized via the cyclo‐oxygenase pathway, in the regulation of monocyte‐mediated killing of virulent and avirulent strains of P. brasiliensis and that TNF‐α generation during the fungus–monocyte interaction is more important in the killing of Pb265 than Pb18.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1046/j.1365-2567.2001.01179.x</identifier><identifier>PMID: 11328382</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Cell Culture Techniques ; Cyclooxygenase Inhibitors - pharmacology ; g-Interferon ; Humans ; indomethacin ; Indomethacin - pharmacology ; Interferon-gamma - immunology ; Monocytes - drug effects ; Monocytes, Activated Killer - immunology ; Original ; Paracoccidioides - pathogenicity ; Paracoccidioides brasiliensis ; Paracoccidioidomycosis - immunology ; Prostaglandins - immunology ; tumor necrosis factor-^a ; Tumor Necrosis Factor-alpha - immunology ; Virulence</subject><ispartof>Immunology, 2001-04, Vol.102 (4), p.480-485</ispartof><rights>2001 Blackwell Science Ltd 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5019-e4dd0deb234870ae4ca93b079f8320ce39fc405f40c9c15b9e72e25cfedb46453</citedby><cites>FETCH-LOGICAL-c5019-e4dd0deb234870ae4ca93b079f8320ce39fc405f40c9c15b9e72e25cfedb46453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783200/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783200/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11328382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soares, A. M. V. C.</creatorcontrib><creatorcontrib>Calvi, S. A.</creatorcontrib><creatorcontrib>Peraçoli, M. T. S.</creatorcontrib><creatorcontrib>Fernandez, A. C.</creatorcontrib><creatorcontrib>Dias, L. A.</creatorcontrib><creatorcontrib>Dos Anjos, A. R.</creatorcontrib><title>Modulatory effect of prostaglandins on human monocyte activation for killing of high‐ and low‐virulence strains of Paracoccidioides brasiliensis</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Summary
The effect of indomethacin (Indo), a cyclo‐oxygenase inhibitor, on the monocyte‐mediated killing of a low‐ (Pb265) and a high‐ (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non‐activated or interferon‐γ (IFN‐γ) ‐activated human monocytes but these cells did show fungicidal activity if pretreated with Indo. In contrast with IFN‐γ, tumour necrosis factor‐α (TNF‐α) was very effective at stimulating the fungicidal activity of monocytes. While the low‐virulence strain, Pb265, could not be killed by monocytes, cells preincubated with IFN‐γ demonstrated fungicidal activity. The killing of this strain was also induced by pretreatment of monocytes with Indo. The results suggest a negative role for prostaglandins, which are synthesized via the cyclo‐oxygenase pathway, in the regulation of monocyte‐mediated killing of virulent and avirulent strains of P. brasiliensis and that TNF‐α generation during the fungus–monocyte interaction is more important in the killing of Pb265 than Pb18.</description><subject>Adult</subject><subject>Cell Culture Techniques</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>g-Interferon</subject><subject>Humans</subject><subject>indomethacin</subject><subject>Indomethacin - pharmacology</subject><subject>Interferon-gamma - immunology</subject><subject>Monocytes - drug effects</subject><subject>Monocytes, Activated Killer - immunology</subject><subject>Original</subject><subject>Paracoccidioides - pathogenicity</subject><subject>Paracoccidioides brasiliensis</subject><subject>Paracoccidioidomycosis - immunology</subject><subject>Prostaglandins - immunology</subject><subject>tumor necrosis factor-^a</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Virulence</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctuEzEUtRCIhsIvIK_YZfBjPI8FSKgqUKkRLGBteTzXiYPHDvZM2uz4BBZ8IV-Cp4kKrGDla52Hz_VBCFNSUFJWL7cF5ZVYMlHVBSOEFoTSui1uH6DFPfAQLTLSLllDxBl6ktI2XzkR4jE6o5SzhjdsgX6sQj85NYZ4wGAM6BEHg3cxpFGtnfK99QkHjzfToDwegg_6MAJWerR7NdqMmBDxF-uc9etZurHrzc9v33GWYhdu8ri3cXLgNeA0RnXnZ_BHFZUOWtveBttDwl1UyToLPtn0FD0yyiV4djrP0ee3l58u3i-vP7y7unhzvdRi3gzKvic9dIyXTU0UlFq1vCN1axrOiAbeGl0SYUqiW01F10LNgAltoO_KqhT8HL0--u6mboBeg88BndxFO6h4kEFZ-Tfi7Uauw17Sen6BZIMXJ4MYvk6QRjnYpMHlj4MwJVmThjasbf5JzIYVb-gcqTkSda4gRTD3aSiRc_dyK-eK5VyxnLuXd93L2yx9_uc2v4WnsjPh1ZFwYx0c_ttYXq1W88R_Ac9XxO0</recordid><startdate>200104</startdate><enddate>200104</enddate><creator>Soares, A. M. V. C.</creator><creator>Calvi, S. A.</creator><creator>Peraçoli, M. T. S.</creator><creator>Fernandez, A. C.</creator><creator>Dias, L. A.</creator><creator>Dos Anjos, A. R.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200104</creationdate><title>Modulatory effect of prostaglandins on human monocyte activation for killing of high‐ and low‐virulence strains of Paracoccidioides brasiliensis</title><author>Soares, A. M. V. C. ; Calvi, S. A. ; Peraçoli, M. T. S. ; Fernandez, A. C. ; Dias, L. A. ; Dos Anjos, A. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5019-e4dd0deb234870ae4ca93b079f8320ce39fc405f40c9c15b9e72e25cfedb46453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Cell Culture Techniques</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>g-Interferon</topic><topic>Humans</topic><topic>indomethacin</topic><topic>Indomethacin - pharmacology</topic><topic>Interferon-gamma - immunology</topic><topic>Monocytes - drug effects</topic><topic>Monocytes, Activated Killer - immunology</topic><topic>Original</topic><topic>Paracoccidioides - pathogenicity</topic><topic>Paracoccidioides brasiliensis</topic><topic>Paracoccidioidomycosis - immunology</topic><topic>Prostaglandins - immunology</topic><topic>tumor necrosis factor-^a</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soares, A. M. V. C.</creatorcontrib><creatorcontrib>Calvi, S. A.</creatorcontrib><creatorcontrib>Peraçoli, M. T. S.</creatorcontrib><creatorcontrib>Fernandez, A. C.</creatorcontrib><creatorcontrib>Dias, L. A.</creatorcontrib><creatorcontrib>Dos Anjos, A. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soares, A. M. V. C.</au><au>Calvi, S. A.</au><au>Peraçoli, M. T. S.</au><au>Fernandez, A. C.</au><au>Dias, L. A.</au><au>Dos Anjos, A. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulatory effect of prostaglandins on human monocyte activation for killing of high‐ and low‐virulence strains of Paracoccidioides brasiliensis</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2001-04</date><risdate>2001</risdate><volume>102</volume><issue>4</issue><spage>480</spage><epage>485</epage><pages>480-485</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
The effect of indomethacin (Indo), a cyclo‐oxygenase inhibitor, on the monocyte‐mediated killing of a low‐ (Pb265) and a high‐ (Pb18) virulence strain of Paracoccidioides brasiliensis was examined. The Pb18 strain was not killed by either non‐activated or interferon‐γ (IFN‐γ) ‐activated human monocytes but these cells did show fungicidal activity if pretreated with Indo. In contrast with IFN‐γ, tumour necrosis factor‐α (TNF‐α) was very effective at stimulating the fungicidal activity of monocytes. While the low‐virulence strain, Pb265, could not be killed by monocytes, cells preincubated with IFN‐γ demonstrated fungicidal activity. The killing of this strain was also induced by pretreatment of monocytes with Indo. The results suggest a negative role for prostaglandins, which are synthesized via the cyclo‐oxygenase pathway, in the regulation of monocyte‐mediated killing of virulent and avirulent strains of P. brasiliensis and that TNF‐α generation during the fungus–monocyte interaction is more important in the killing of Pb265 than Pb18.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11328382</pmid><doi>10.1046/j.1365-2567.2001.01179.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Cell Culture Techniques Cyclooxygenase Inhibitors - pharmacology g-Interferon Humans indomethacin Indomethacin - pharmacology Interferon-gamma - immunology Monocytes - drug effects Monocytes, Activated Killer - immunology Original Paracoccidioides - pathogenicity Paracoccidioides brasiliensis Paracoccidioidomycosis - immunology Prostaglandins - immunology tumor necrosis factor-^a Tumor Necrosis Factor-alpha - immunology Virulence |
| title | Modulatory effect of prostaglandins on human monocyte activation for killing of high‐ and low‐virulence strains of Paracoccidioides brasiliensis |
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