Cellular immune responses induced in cattle by heterologous prime–boost vaccination using recombinant viruses and bacille Calmette–Guérin

Summary The development of novel vaccine strategies to replace or supplement bacille Calmette–Guérin (BCG) is urgently required. Here we study, in cattle, the use of heterologous prime–boost strategies based on vaccination with BCG and the mycobacterial mycolyl transferase Ag85A (Rv3804c) expressed...

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Veröffentlicht in:	Immunology 2004-07, Vol.112 (3), p.461-470
Hauptverfasser:	Vordermeier, H. Martin, Rhodes, Shelley G., Dean, Gillian, Goonetilleke, Nilu, Huygen, Kris, Hill, Adrian V. S., Hewinson, R. Glyn, Gilbert, Sarah C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - administration & dosage Animals Antigens, Bacterial - administration & dosage bacteria BCG Vaccine - administration & dosage Cattle Cell Line Fowlpox virus - genetics Immunization, Secondary Interferon-gamma - immunology Lymphocyte Activation Mycobacterium bovis Original Recombinant Proteins - administration & dosage recombinant viruses T-Lymphocytes - immunology Tuberculosis, Bovine - immunology Vaccination Vaccines, Synthetic - administration & dosage Vaccinia virus Vaccinia virus - genetics
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