Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activation

Summary FOXP3 has been identified as a key regulator of immune homeostasis. Mutations within the FOXP3 gene result in dysregulated CD4+ T‐cell function and elevated cytokine production, leading to lymphoproliferative disease. FOXP3 expression in CD4+ T cells is primarily detected with the CD4+ CD25+...

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Veröffentlicht in:	Immunology 2006-10, Vol.119 (2), p.203-211
Hauptverfasser:	Smith, Emma L., Finney, Helene M., Nesbitt, Andrew M., Ramsdell, Fred, Robinson, Martyn K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence CD28 Antigens - immunology CD4-Positive T-Lymphocytes - immunology Cell Proliferation Cells, Cultured chimeric receptors Cloning, Molecular Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism FOXP3 human T lymphocytes Humans Immune Tolerance - genetics Immune Tolerance - immunology inhibition of T‐cell activation Lymphocyte Activation - genetics Lymphocyte Activation - immunology Molecular Sequence Data Original Protein Isoforms - genetics Protein Isoforms - immunology Receptors, Antigen, T-Cell - immunology RNA Splice Sites - genetics Sequence Alignment splice variants Transfection
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