The Angiogenic Switch Molecule, Secreted FGF-Binding Protein, an Indicator of Early Stages of Pancreatic and Colorectal Adenocarcinoma
Tumor angiogenesis has been related to the initiation as well as progression toward more aggressive behavior of human tumors. We will discuss genetic events underlying the initiation and progression of colorectal and pancreatic adenocarcinoma with a particular focus on the modulation of angiogenesis...
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| Veröffentlicht in: | Seminars in oncology 2006-12, Vol.33 (6), p.50-56 |
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| container_title | Seminars in oncology |
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| creator | Tassi, Elena Wellstein, Anton |
| description | Tumor angiogenesis has been related to the initiation as well as progression toward more aggressive behavior of human tumors. We will discuss genetic events underlying the initiation and progression of colorectal and pancreatic adenocarcinoma with a particular focus on the modulation of angiogenesis. A secreted fibroblast growth factor (FGF) binding protein (FGF-BP), which is an extracellular chaperone molecule for FGFs, has been shown to enhance FGF-mediated biochemical and biologic events and to be a crucial rate-limiting factor for tumor-dependent angiogenesis. Histochemical and in situ hybridization studies with archival samples show that FGF-BP is induced early during the initiation of colorectal and pancreatic adenocarcinoma. We will discuss the potential of this secreted protein as a serum marker to identify at-risk subjects. |
| doi_str_mv | 10.1053/j.seminoncol.2006.10.014 |
| format | Article |
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We will discuss genetic events underlying the initiation and progression of colorectal and pancreatic adenocarcinoma with a particular focus on the modulation of angiogenesis. A secreted fibroblast growth factor (FGF) binding protein (FGF-BP), which is an extracellular chaperone molecule for FGFs, has been shown to enhance FGF-mediated biochemical and biologic events and to be a crucial rate-limiting factor for tumor-dependent angiogenesis. Histochemical and in situ hybridization studies with archival samples show that FGF-BP is induced early during the initiation of colorectal and pancreatic adenocarcinoma. We will discuss the potential of this secreted protein as a serum marker to identify at-risk subjects.</description><subject>Adenocarcinoma - blood supply</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carrier Proteins - blood</subject><subject>Colorectal Neoplasms - blood supply</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Neovascularization, Pathologic - blood</subject><subject>Pancreatic Neoplasms - blood supply</subject><subject>Tumors</subject><issn>0093-7754</issn><issn>1532-8708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1vEzEQXSEQDYW_gHyBUzfY3g87F6Q0atpKRVRKOVve2dmNI69d7E1R_wC_G68SNXDiZHnmvTcz72UZYXTOaFV82c0jDsZ5B97OOaV1Ks8pK19lM1YVPJeCytfZjNJFkQtRlWfZuxh3lHImOH-bnTHBhORSzrLfD1skS9cb36MzQDa_zAhb8s1bhL3FC7JBCDhiS9bX6_zSuNa4ntwHP6JxF0Q7cptKoEcfiO_IlQ72mWxG3WOc_vfaJboek7J2LVl56wPCqC1Ztug86ADpjEG_z9502kb8cHzPsx_rq4fVTX73_fp2tbzLoRLFmEPRQAe6EguBAJ1oRSHqsmB13TScV6Lj2HJW8qJsy3pRoagb3smOcVY3FTZlcZ59Peg-7psBW0A3Bm3VYzCDDs_Ka6P-7TizVb1_UskvVi5kEvh8FAj-5x7jqAYTAa3VDv0-qlryStJ6miQPQAg-xoDdyxBG1RSi2qlTiGoKceqkEBP1499LnojH1BLg0xGgI2jbheSyiSecLMuqYBPu8oDDZOmTwaAiGHSArZlSUK03_9_mDwc0woA</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Tassi, Elena</creator><creator>Wellstein, Anton</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20061201</creationdate><title>The Angiogenic Switch Molecule, Secreted FGF-Binding Protein, an Indicator of Early Stages of Pancreatic and Colorectal Adenocarcinoma</title><author>Tassi, Elena ; Wellstein, Anton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-c3bcfca5797eccf7d737643166bb2257f2ed214234d4695e76b2f8f1216b5eb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenocarcinoma - blood supply</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carrier Proteins - blood</topic><topic>Colorectal Neoplasms - blood supply</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Neovascularization, Pathologic - blood</topic><topic>Pancreatic Neoplasms - blood supply</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tassi, Elena</creatorcontrib><creatorcontrib>Wellstein, Anton</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tassi, Elena</au><au>Wellstein, Anton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Angiogenic Switch Molecule, Secreted FGF-Binding Protein, an Indicator of Early Stages of Pancreatic and Colorectal Adenocarcinoma</atitle><jtitle>Seminars in oncology</jtitle><addtitle>Semin Oncol</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>33</volume><issue>6</issue><spage>50</spage><epage>56</epage><pages>50-56</pages><issn>0093-7754</issn><eissn>1532-8708</eissn><coden>SOLGAV</coden><abstract>Tumor angiogenesis has been related to the initiation as well as progression toward more aggressive behavior of human tumors. 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| identifier | ISSN: 0093-7754 |
| ispartof | Seminars in oncology, 2006-12, Vol.33 (6), p.50-56 |
| issn | 0093-7754 1532-8708 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenocarcinoma - blood supply Biological and medical sciences Biomarkers, Tumor - blood Carrier Proteins - blood Colorectal Neoplasms - blood supply Gastroenterology. Liver. Pancreas. Abdomen Humans Intercellular Signaling Peptides and Proteins Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Neovascularization, Pathologic - blood Pancreatic Neoplasms - blood supply Tumors |
| title | The Angiogenic Switch Molecule, Secreted FGF-Binding Protein, an Indicator of Early Stages of Pancreatic and Colorectal Adenocarcinoma |
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