Differential Functions of Tumor Necrosis Factor Receptor 1 and 2 Signaling in Ischemia-Mediated Arteriogenesis and Angiogenesis

We have previously shown that tumor necrosis factor (TNF) acts via its two receptors TNFR1 and TNFR2 to elicit distinct signaling pathways in vascular endothelial cells (ECs). Here we used a femoral artery ligation model to demonstrate that TNFR1-knockout (KO) mice had enhanced, whereas TNFR2-KO had...

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Veröffentlicht in:	The American journal of pathology 2006-11, Vol.169 (5), p.1886-1898
Hauptverfasser:	Luo, Dianhong, Luo, Yan, He, Yun, Zhang, Haifeng, Zhang, Rong, Li, Xianghong, Dobrucki, Wawrzyniec L., Sinusas, Al J., Sessa, William C., Min, Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Arteries - embryology Biological and medical sciences Blood Vessels Cattle Cell Movement Cell Proliferation Cell Survival Endothelial Cells - cytology Endothelial Cells - pathology Endothelium, Vascular - pathology Hindlimb - cytology Hindlimb - pathology Humans Investigative techniques, diagnostic techniques (general aspects) Ischemia - chemically induced Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Neovascularization, Pathologic Organogenesis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Perfusion Protein-Tyrosine Kinases - metabolism Receptors, Tumor Necrosis Factor, Type I - chemistry Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - metabolism Regular Signal Transduction TNF Receptor-Associated Factor 2 - metabolism
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