Growth Regulation via Insulin-Like Growth Factor Binding Protein-4 and −2 in Association with Mutant K-ras in Lung Epithelia

Gain-of-function point mutations in K-ras affect early events in pulmonary bronchioloalveolar carcinoma. We investigated altered mRNA expression on K-Ras activation in human peripheral lung epithelial cells (HPL1A) using oligonucleotide microarrays. Mutated K-Ras stably expressed in HPL1A accelerate...

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