Depletion of trace elements and acute ocular toxicity induced by desferrioxamine in patients with thalassaemia

High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high...

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