Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by use of fluorescein dilaurate test
In the fluorescein dilaurate test fluorescein dilaurate is cleaved by the pancreas specific cholesterol ester hydrolase activity and the liberated fluorescein is absorbed and excreted in the urine. Fluorescein recovery is a reflection of exocrine pancreatic function. The test was evaluated in 14 pat...
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| Veröffentlicht in: | Archives of disease in childhood 1986-06, Vol.61 (6), p.573-575 |
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| creator | Cumming, J G Forsyth, J S Boyd, E J Frost, G J Cuschieri, A |
| description | In the fluorescein dilaurate test fluorescein dilaurate is cleaved by the pancreas specific cholesterol ester hydrolase activity and the liberated fluorescein is absorbed and excreted in the urine. Fluorescein recovery is a reflection of exocrine pancreatic function. The test was evaluated in 14 patients with cystic fibrosis and 16 healthy volunteers. The test was well tolerated by patients, was easy to perform, and gave significantly lower values in the patients suffering from cystic fibrosis. The result of the pancreolauryl test was also correlated with the result of the faecal chymotrypsin test in 11 of the patients suffering from cystic fibrosis. A positive correlation was found between the two test results. The test is a practical and reliable index of pancreatic exocrine function and may have a useful role as a screening procedure. |
| doi_str_mv | 10.1136/adc.61.6.573 |
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Fluorescein recovery is a reflection of exocrine pancreatic function. The test was evaluated in 14 patients with cystic fibrosis and 16 healthy volunteers. The test was well tolerated by patients, was easy to perform, and gave significantly lower values in the patients suffering from cystic fibrosis. The result of the pancreolauryl test was also correlated with the result of the faecal chymotrypsin test in 11 of the patients suffering from cystic fibrosis. A positive correlation was found between the two test results. The test is a practical and reliable index of pancreatic exocrine function and may have a useful role as a screening procedure.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.61.6.573</identifier><identifier>PMID: 3729527</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Child, Preschool ; Chymotrypsin - analysis ; Cystic Fibrosis - complications ; Cystic Fibrosis - metabolism ; Exocrine Pancreatic Insufficiency - diagnosis ; Exocrine Pancreatic Insufficiency - etiology ; Exocrine Pancreatic Insufficiency - metabolism ; Feces - analysis ; Fluoresceins ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Other diseases. Semiology ; Reference Values</subject><ispartof>Archives of disease in childhood, 1986-06, Vol.61 (6), p.573-575</ispartof><rights>1986 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jun 1986</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-eb42962555d9acb716df3cd2837ebe5e91f1933c29bbd284f82d2cf0e0603ede3</citedby><cites>FETCH-LOGICAL-b506t-eb42962555d9acb716df3cd2837ebe5e91f1933c29bbd284f82d2cf0e0603ede3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1777862/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1777862/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8793645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3729527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cumming, J G</creatorcontrib><creatorcontrib>Forsyth, J S</creatorcontrib><creatorcontrib>Boyd, E J</creatorcontrib><creatorcontrib>Frost, G J</creatorcontrib><creatorcontrib>Cuschieri, A</creatorcontrib><title>Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by use of fluorescein dilaurate test</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>In the fluorescein dilaurate test fluorescein dilaurate is cleaved by the pancreas specific cholesterol ester hydrolase activity and the liberated fluorescein is absorbed and excreted in the urine. Fluorescein recovery is a reflection of exocrine pancreatic function. The test was evaluated in 14 patients with cystic fibrosis and 16 healthy volunteers. The test was well tolerated by patients, was easy to perform, and gave significantly lower values in the patients suffering from cystic fibrosis. The result of the pancreolauryl test was also correlated with the result of the faecal chymotrypsin test in 11 of the patients suffering from cystic fibrosis. A positive correlation was found between the two test results. The test is a practical and reliable index of pancreatic exocrine function and may have a useful role as a screening procedure.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chymotrypsin - analysis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - metabolism</subject><subject>Exocrine Pancreatic Insufficiency - diagnosis</subject><subject>Exocrine Pancreatic Insufficiency - etiology</subject><subject>Exocrine Pancreatic Insufficiency - metabolism</subject><subject>Feces - analysis</subject><subject>Fluoresceins</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Reference Values</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhS0EKtPCji1SJFDZkMGP-LVBQlNakCrYQMXOsp3r4iGTTO0Edf49DjMaAQtWln2-e3SuD0LPCF4SwsQb2_qlIEux5JI9QAvSCFVT3DQP0QJjzGqtlHqMTnNeY0yoUuwEnTBJNadygcJFtLf9kGOuhlDB_eBT7KHa2t4nsGP0VezzFEL0EXq_K7fK7_L8HqJLv-fcrpoyzOOhm4YE2UOh2tjZKdkRqhHy-AQ9CrbL8PRwnqGvl--_rD7U15-vPq7eXdeOYzHW4BqqBeWct9p6J4loA_MtVUyCAw6aBKIZ81Q7V16boGhLfcCABWbQAjtDb_e-28ltoPXQj8l2ZpvixqadGWw0fyt9_G5uh5-GSCmVoMXg_GCQhrupJDebWBbqOtvDMGUjhW4wlriAL_4B18OU-rJc8RJa6uI4273eU778VU4QjlEINnN7prRnBDHClPYK_vzP-Ef4UFfRXx50m73tQio1xXzElNRMNLxg9R6LeYT7o2zTDyMkk9x8ulkZefPtil5ccjPv8mrPu836_wF_AXiRwJE</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>Cumming, J G</creator><creator>Forsyth, J S</creator><creator>Boyd, E J</creator><creator>Frost, G J</creator><creator>Cuschieri, A</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860601</creationdate><title>Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by use of fluorescein dilaurate test</title><author>Cumming, J G ; Forsyth, J S ; Boyd, E J ; Frost, G J ; Cuschieri, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-eb42962555d9acb716df3cd2837ebe5e91f1933c29bbd284f82d2cf0e0603ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chymotrypsin - analysis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - metabolism</topic><topic>Exocrine Pancreatic Insufficiency - diagnosis</topic><topic>Exocrine Pancreatic Insufficiency - etiology</topic><topic>Exocrine Pancreatic Insufficiency - metabolism</topic><topic>Feces - analysis</topic><topic>Fluoresceins</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cumming, J G</creatorcontrib><creatorcontrib>Forsyth, J S</creatorcontrib><creatorcontrib>Boyd, E J</creatorcontrib><creatorcontrib>Frost, G J</creatorcontrib><creatorcontrib>Cuschieri, A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cumming, J G</au><au>Forsyth, J S</au><au>Boyd, E J</au><au>Frost, G J</au><au>Cuschieri, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by use of fluorescein dilaurate test</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>61</volume><issue>6</issue><spage>573</spage><epage>575</epage><pages>573-575</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>In the fluorescein dilaurate test fluorescein dilaurate is cleaved by the pancreas specific cholesterol ester hydrolase activity and the liberated fluorescein is absorbed and excreted in the urine. Fluorescein recovery is a reflection of exocrine pancreatic function. The test was evaluated in 14 patients with cystic fibrosis and 16 healthy volunteers. The test was well tolerated by patients, was easy to perform, and gave significantly lower values in the patients suffering from cystic fibrosis. The result of the pancreolauryl test was also correlated with the result of the faecal chymotrypsin test in 11 of the patients suffering from cystic fibrosis. A positive correlation was found between the two test results. The test is a practical and reliable index of pancreatic exocrine function and may have a useful role as a screening procedure.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>3729527</pmid><doi>10.1136/adc.61.6.573</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1986-06, Vol.61 (6), p.573-575 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Child Child, Preschool Chymotrypsin - analysis Cystic Fibrosis - complications Cystic Fibrosis - metabolism Exocrine Pancreatic Insufficiency - diagnosis Exocrine Pancreatic Insufficiency - etiology Exocrine Pancreatic Insufficiency - metabolism Feces - analysis Fluoresceins Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Reference Values |
| title | Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by use of fluorescein dilaurate test |
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