Bedtime insulin injections: an alternative regimen
Sixteen children (aged 3 to 12 years) participated in a 12 month crossover study comparing bedtime with teatime insulin injections in an endeavour to reduce morning hyperglycaemia. Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. The...
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| Veröffentlicht in: | Archives of disease in childhood 1985-04, Vol.60 (4), p.311-315 |
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| creator | Hinde, F R Johnston, D I |
| description | Sixteen children (aged 3 to 12 years) participated in a 12 month crossover study comparing bedtime with teatime insulin injections in an endeavour to reduce morning hyperglycaemia. Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. There was no overall change in glycosylated haemoglobin. Despite more frequent mild hypoglycaemic attacks, parents preferred the convenience of the later injection. Analysis of individual children's glycosylated haemoglobin values showed that those whose metabolic control improved on the later injection were younger and went to bed earlier, indicating that this regimen may have a place in the management of younger children with diabetes mellitus. |
| doi_str_mv | 10.1136/adc.60.4.311 |
| format | Article |
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Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. There was no overall change in glycosylated haemoglobin. Despite more frequent mild hypoglycaemic attacks, parents preferred the convenience of the later injection. Analysis of individual children's glycosylated haemoglobin values showed that those whose metabolic control improved on the later injection were younger and went to bed earlier, indicating that this regimen may have a place in the management of younger children with diabetes mellitus.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.60.4.311</identifier><identifier>PMID: 3890764</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Biological and medical sciences ; Blood Glucose - metabolism ; Child ; Child, Preschool ; Clinical Trials as Topic ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Drug Administration Schedule ; Female ; Genital system. Reproduction ; Glycated Hemoglobin A - analysis ; Humans ; Hyperglycemia - prevention & control ; Hypoglycemia - etiology ; Injection ; Injections, Subcutaneous ; Insulin ; Insulin - administration & dosage ; Male ; Medical sciences ; Pharmacology. 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Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. There was no overall change in glycosylated haemoglobin. Despite more frequent mild hypoglycaemic attacks, parents preferred the convenience of the later injection. Analysis of individual children's glycosylated haemoglobin values showed that those whose metabolic control improved on the later injection were younger and went to bed earlier, indicating that this regimen may have a place in the management of younger children with diabetes mellitus.</description><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Trials as Topic</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hyperglycemia - prevention & control</subject><subject>Hypoglycemia - etiology</subject><subject>Injection</subject><subject>Injections, Subcutaneous</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Reproduction</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hyperglycemia - prevention & control</topic><topic>Hypoglycemia - etiology</topic><topic>Injection</topic><topic>Injections, Subcutaneous</topic><topic>Insulin</topic><topic>Insulin - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. 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Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. There was no overall change in glycosylated haemoglobin. Despite more frequent mild hypoglycaemic attacks, parents preferred the convenience of the later injection. Analysis of individual children's glycosylated haemoglobin values showed that those whose metabolic control improved on the later injection were younger and went to bed earlier, indicating that this regimen may have a place in the management of younger children with diabetes mellitus.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>3890764</pmid><doi>10.1136/adc.60.4.311</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Blood Glucose - metabolism Child Child, Preschool Clinical Trials as Topic Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Drug Administration Schedule Female Genital system. Reproduction Glycated Hemoglobin A - analysis Humans Hyperglycemia - prevention & control Hypoglycemia - etiology Injection Injections, Subcutaneous Insulin Insulin - administration & dosage Male Medical sciences Pharmacology. Drug treatments Random Allocation |
| title | Bedtime insulin injections: an alternative regimen |
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