THE EFFECT OF ETHACRYNIC ACID ON THE GUINEA‐PIG AND RAT ISOLATED VAS DEFERENS

1 The effect of ethacrynic acid (EA) was studied on guinea‐pig and rat vas deferens in vitro. 2 EA contracted the guinea‐pig but not the rat vas deferens in a dose‐dependent manner (50–800 μg/ml). Tyramine caused contraction in 10 out of 18 guinea‐pig vas deferens; EA caused contraction in 17 of the...

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Veröffentlicht in:	British journal of pharmacology 1974-12, Vol.52 (4), p.579-584
Hauptverfasser:	KHOYI, M.A., POUSTI, A., ZARRINDAST, M.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Cocaine - pharmacology Desipramine - pharmacology Ethacrynic Acid - pharmacology Guinea Pigs Hexamethonium Compounds - pharmacology In Vitro Techniques Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Norepinephrine - pharmacology Pharmacokinetics Phentolamine - pharmacology Rats Reserpine - pharmacology Vas Deferens - drug effects
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