COMPULSIVE GNAWING IN RATS AFTER IMPLANTATION OF DRUGS INTO THE VENTRAL THALAMUS. A CONTRIBUTION TO THE MECHANISM OF MORPHINE ACTION
1 Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses. 2 Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gn...
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| Veröffentlicht in: | British journal of pharmacology 1974-06, Vol.51 (2), p.197-205 |
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| creator | BERGMANN, F. CHAIMOVITZ, M. PASTERNAK(NA'OR), V. RAMU, A. |
| description | 1
Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.
2
Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.
3
The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with α‐methyltyrosine methyl ester or α‐methyldopa prevents only the gnawing response to morphine, but not to apomorphine.
4
Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.
5
Systemic amphetamine potentiates the effect of thalamic deposits of morphine.
6
Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines. |
| doi_str_mv | 10.1111/j.1476-5381.1974.tb09647.x |
| format | Article |
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Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.
2
Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.
3
The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with α‐methyltyrosine methyl ester or α‐methyldopa prevents only the gnawing response to morphine, but not to apomorphine.
4
Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.
5
Systemic amphetamine potentiates the effect of thalamic deposits of morphine.
6
Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1974.tb09647.x</identifier><identifier>PMID: 4281333</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amphetamine - pharmacology ; Animals ; Apomorphine - antagonists & inhibitors ; Apomorphine - pharmacology ; Brain - anatomy & histology ; Chlorpromazine - pharmacology ; Compulsive Behavior - drug effects ; Corpus Striatum - drug effects ; Disulfiram - pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Fenclonine - pharmacology ; Haloperidol - pharmacology ; Humans ; Meperidine - pharmacology ; Methadone - pharmacology ; Methyldopa - pharmacology ; Methyltyrosines - pharmacology ; Morphine - antagonists & inhibitors ; Morphine - pharmacology ; Nalorphine - pharmacology ; Phenoxybenzamine - pharmacology ; Phentolamine - pharmacology ; Pimozide - pharmacology ; Rats ; Systematic Pharmacology ; Thalamus - drug effects</subject><ispartof>British journal of pharmacology, 1974-06, Vol.51 (2), p.197-205</ispartof><rights>1974 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3007-df37b3c13ce7265eec78c471b82cc8853d1e085d93382bbcc4c37711819e6df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1776745/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1776745/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4281333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERGMANN, F.</creatorcontrib><creatorcontrib>CHAIMOVITZ, M.</creatorcontrib><creatorcontrib>PASTERNAK(NA'OR), V.</creatorcontrib><creatorcontrib>RAMU, A.</creatorcontrib><title>COMPULSIVE GNAWING IN RATS AFTER IMPLANTATION OF DRUGS INTO THE VENTRAL THALAMUS. A CONTRIBUTION TO THE MECHANISM OF MORPHINE ACTION</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.
2
Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.
3
The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with α‐methyltyrosine methyl ester or α‐methyldopa prevents only the gnawing response to morphine, but not to apomorphine.
4
Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.
5
Systemic amphetamine potentiates the effect of thalamic deposits of morphine.
6
Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.</description><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Apomorphine - antagonists & inhibitors</subject><subject>Apomorphine - pharmacology</subject><subject>Brain - anatomy & histology</subject><subject>Chlorpromazine - pharmacology</subject><subject>Compulsive Behavior - drug effects</subject><subject>Corpus Striatum - drug effects</subject><subject>Disulfiram - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Fenclonine - pharmacology</subject><subject>Haloperidol - pharmacology</subject><subject>Humans</subject><subject>Meperidine - pharmacology</subject><subject>Methadone - pharmacology</subject><subject>Methyldopa - pharmacology</subject><subject>Methyltyrosines - pharmacology</subject><subject>Morphine - antagonists & inhibitors</subject><subject>Morphine - pharmacology</subject><subject>Nalorphine - pharmacology</subject><subject>Phenoxybenzamine - pharmacology</subject><subject>Phentolamine - pharmacology</subject><subject>Pimozide - pharmacology</subject><subject>Rats</subject><subject>Systematic Pharmacology</subject><subject>Thalamus - drug effects</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUVtPwjAUbowGEf0JJo3vzJZua_FBU-ZgTXYhu-hjw0pRCILZvMC7P9xOCNFHz8s56XdpzvkAuMLIwqauFxa2qdt1CMMW7lPbeitR37WptTkC7QN0DNoIIdrFmLFTcFbXC4QMSJ0WaNk9hgkhbfDlJdG4CDPx4MNRzB9FPIIihinPM8iHuZ9CEY1DHuc8F0kMkyG8T4tRZjh5AvPAhw9-nKc8NDMPeVRkFuTQS8ybGBQ_kj0v8r2AxyKLGo8oSceBiH3IvYZzDk5mk2WtL_a9A4qhn3tBN0xGwuNhV5FmkemM0JIoTJSmPdfRWlGmbIpL1lOKMYdMsUbMmfYJYb2yVMpWhFKzPu5r14hJB9zufF_fyxc9VXr1Vk2W8rWav0yqrVxP5vIvspo_y6f1h8SUutR2jMHNzkBV67qu9OygxUg20ciFbO4vm_vLJhq5j0ZujPjy9-8H6T4Lg9_t8M_5Um__4SwH46CZyDc6aZWz</recordid><startdate>197406</startdate><enddate>197406</enddate><creator>BERGMANN, F.</creator><creator>CHAIMOVITZ, M.</creator><creator>PASTERNAK(NA'OR), V.</creator><creator>RAMU, A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>197406</creationdate><title>COMPULSIVE GNAWING IN RATS AFTER IMPLANTATION OF DRUGS INTO THE VENTRAL THALAMUS. A CONTRIBUTION TO THE MECHANISM OF MORPHINE ACTION</title><author>BERGMANN, F. ; CHAIMOVITZ, M. ; PASTERNAK(NA'OR), V. ; RAMU, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3007-df37b3c13ce7265eec78c471b82cc8853d1e085d93382bbcc4c37711819e6df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Apomorphine - antagonists & inhibitors</topic><topic>Apomorphine - pharmacology</topic><topic>Brain - anatomy & histology</topic><topic>Chlorpromazine - pharmacology</topic><topic>Compulsive Behavior - drug effects</topic><topic>Corpus Striatum - drug effects</topic><topic>Disulfiram - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Fenclonine - pharmacology</topic><topic>Haloperidol - pharmacology</topic><topic>Humans</topic><topic>Meperidine - pharmacology</topic><topic>Methadone - pharmacology</topic><topic>Methyldopa - pharmacology</topic><topic>Methyltyrosines - pharmacology</topic><topic>Morphine - antagonists & inhibitors</topic><topic>Morphine - pharmacology</topic><topic>Nalorphine - pharmacology</topic><topic>Phenoxybenzamine - pharmacology</topic><topic>Phentolamine - pharmacology</topic><topic>Pimozide - pharmacology</topic><topic>Rats</topic><topic>Systematic Pharmacology</topic><topic>Thalamus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERGMANN, F.</creatorcontrib><creatorcontrib>CHAIMOVITZ, M.</creatorcontrib><creatorcontrib>PASTERNAK(NA'OR), V.</creatorcontrib><creatorcontrib>RAMU, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERGMANN, F.</au><au>CHAIMOVITZ, M.</au><au>PASTERNAK(NA'OR), V.</au><au>RAMU, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMPULSIVE GNAWING IN RATS AFTER IMPLANTATION OF DRUGS INTO THE VENTRAL THALAMUS. A CONTRIBUTION TO THE MECHANISM OF MORPHINE ACTION</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1974-06</date><risdate>1974</risdate><volume>51</volume><issue>2</issue><spage>197</spage><epage>205</epage><pages>197-205</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1
Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.
2
Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.
3
The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with α‐methyltyrosine methyl ester or α‐methyldopa prevents only the gnawing response to morphine, but not to apomorphine.
4
Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.
5
Systemic amphetamine potentiates the effect of thalamic deposits of morphine.
6
Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>4281333</pmid><doi>10.1111/j.1476-5381.1974.tb09647.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 1974-06, Vol.51 (2), p.197-205 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Amphetamine - pharmacology Animals Apomorphine - antagonists & inhibitors Apomorphine - pharmacology Brain - anatomy & histology Chlorpromazine - pharmacology Compulsive Behavior - drug effects Corpus Striatum - drug effects Disulfiram - pharmacology Dose-Response Relationship, Drug Drug Synergism Fenclonine - pharmacology Haloperidol - pharmacology Humans Meperidine - pharmacology Methadone - pharmacology Methyldopa - pharmacology Methyltyrosines - pharmacology Morphine - antagonists & inhibitors Morphine - pharmacology Nalorphine - pharmacology Phenoxybenzamine - pharmacology Phentolamine - pharmacology Pimozide - pharmacology Rats Systematic Pharmacology Thalamus - drug effects |
| title | COMPULSIVE GNAWING IN RATS AFTER IMPLANTATION OF DRUGS INTO THE VENTRAL THALAMUS. A CONTRIBUTION TO THE MECHANISM OF MORPHINE ACTION |
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