Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain

Selective activation of the peripheral cannabinoid receptor 1 (CB 1R) has been shown to suppress neuropathic pain symptoms in rodents. However, relatively little is known about changes in CB 1R and its endogenous ligands during development or maintenance of neuropathic pain. Using immunohistochemist...

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Veröffentlicht in:	Pain (Amsterdam) 2006-12, Vol.126 (1), p.102-114
Hauptverfasser:	Mitrirattanakul, Somsak, Ramakul, Navapoln, Guerrero, Andre V., Matsuka, Yoshizo, Ono, Takeshi, Iwase, Hirotate, Mackie, Ken, Faull, Kym F., Spigelman, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	2-arachidonoylglycerol Analgesics Anandamide Animals Biological and medical sciences Cannabinoid 1 receptors Cannabinoid Receptor Modulators - metabolism Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Endocannabinoid system Ganglia, Spinal - metabolism Hot Temperature Immunohistochemistry L5 spinal nerve ligation Ligands Ligation Lumbosacral Region Male Medical sciences Nervous system (semeiology, syndromes) Neuralgia - metabolism Neurology Neuropharmacology Pharmacology. Drug treatments Physical Stimulation Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Receptors, Cannabinoid - metabolism RNA, Messenger - metabolism Spinal Nerves Tissue Distribution
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