Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas

Background and aims: Hepatitis B virus (HBV) DNA integration into or close to cellular genes is frequently detected in HBV positive hepatocellular carcinomas (HCC). We have previously shown that viral integration can lead to aberrant target gene transcription. In this study, we attempted to investig...

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Veröffentlicht in:	Gut 2005-08, Vol.54 (8), p.1162-1168
Hauptverfasser:	Murakami, Y, Saigo, K, Takashima, H, Minami, M, Okanoue, T, Bréchot, C, Paterlini-Bréchot, P
Format:	Artikel
Sprache:	eng
Schlagworte:	adenomatous poliposis coli-like Adolescent Adult Aged Aged, 80 and over Antigens APCL Apoptosis Biological and medical sciences Calcium Signaling - genetics Calcium signalling Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Cell cycle Deoxyribonucleic acid DNA DNA integration DNA Transposable Elements - genetics DNA, Viral - genetics DNA-Binding Proteins Female Gastroenterology. Liver. Pancreas. Abdomen Gene therapy Genes Genes, Tumor Suppressor Genomes HBV HCC Hematologic and hematopoietic diseases Hepatitis Hepatitis B Hepatitis B - genetics Hepatitis B virus Hepatitis B virus - genetics Hepatocellular carcinoma HPV hTERT human papillomavirus human telomerase reverse transcriptase Human viral diseases Humans Infectious diseases Insertion Integration Leukemia Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Liver cancer Liver cirrhosis Liver Neoplasms - genetics Liver Neoplasms - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphoma Male Medical research Medical sciences MGMT Middle Aged mixed lineage leukaemia MLL Mutagenesis Neoplasm Proteins - genetics O6-methylguanine DNA methyltransferase PCR PDGF platelet derived growth factor Platelet-Derived Growth Factor - genetics Polymerase chain reaction Polymerase Chain Reaction - methods Proteins Ribosomal Proteins - genetics RNA-directed DNA polymerase Signal transduction Studies Telomerase Telomerase - genetics Telomerase reverse transcriptase Transcription Tumor suppressor genes Tumors Viral diseases Viral Hepatitis Viral Proteins - genetics Virus Integration Viruses WHV Woodchuck hepatitis virus
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