First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

Background: Transferrin receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in humans cause type 3 haemochromatosis and a targeted mutation in mice leads to iron overload with a similar phenotype. We have previously described the generation of a complete TfR...

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Veröffentlicht in:	Gut 2005-07, Vol.54 (7), p.980-986
Hauptverfasser:	Wallace, D F, Summerville, L, Lusby, P E, Subramaniam, V N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - genetics Binding sites Biological and medical sciences DcytB divalent metal transporter 1 DMT1 duodenal cytochrome B Duodenum - metabolism ferroportin Fpn1 Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation Genes haemochromatosis hemojuvelin hepcidin Hepcidins Hjv Homeostasis Immunoenzyme Techniques Immunoglobulins Inflammation Iron iron metabolism Iron Overload - genetics Iron Overload - metabolism knockout knockout mouse Laboratories Liver - metabolism Liver Disease Male Medical research Medical sciences Metabolic diseases Metals (hemochromatosis...) Mice Mice, Inbred C57BL Mice, Knockout - genetics Mice, Knockout - metabolism Mutation Other metabolic disorders PBS PCR Phenotype phosphate buffered saline polymerase chain reaction Polymerase Chain Reaction - methods Proteins Receptors, Transferrin - genetics Receptors, Transferrin - metabolism Receptors, Transferrin - physiology RNA, Messenger - genetics Rodents Spleen Spleen - metabolism TfR1 TfR2 transferrin receptor 1 transferrin receptor 2
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