Long term failure of endoscopic gastroplication (EndoCinch)
Introduction: Endoluminal gastroplication (EndoCinch; Bard) has been introduced as an endoscopic treatment option in gastro-oesophageal reflux disease (GORD) patients with promising short term results. However, little is known about the long term efficacy of endoscopic suturing. The aim of this stud...
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| Veröffentlicht in: | Gut 2005-06, Vol.54 (6), p.752-758 |
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| description | Introduction: Endoluminal gastroplication (EndoCinch; Bard) has been introduced as an endoscopic treatment option in gastro-oesophageal reflux disease (GORD) patients with promising short term results. However, little is known about the long term efficacy of endoscopic suturing. The aim of this study was to evaluate prospectively the long term outcome after EndoCinch. Patients and methods: A total of 70 patients treated with EndoCinch at a single referral centre were studied prospectively. All patients were interviewed using a standardised questionnaire regarding their symptoms and medication prior to and 18 months after EndoCinch. In addition, follow up included endoscopy, 24 hour pH monitoring, and oesophageal manometry. Results: The procedure was well tolerated without major short or long term complications. Eighteen months after EndoCinch, 56/70 patients (80%) were considered treatment failures as their heartburn symptoms did not improve or proton pump inhibitor medication exceeded 50% of the initial dose. Endoscopy showed all sutures in situ in 12/70 (17%) patients while no remaining sutures could be detected in 18/70 (26%). In 54 and 50 patients examined, respectively, no significant changes in 24 hour pH monitoring (median pH |
| doi_str_mv | 10.1136/gut.2004.058354 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1774515</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4014123811</sourcerecordid><originalsourceid>FETCH-LOGICAL-b617t-fff164740b112b72111ccf7bf3a0d1c2ca314cd9fc23fb407976c1828143cc5d3</originalsourceid><addsrcrecordid>eNqF0c9rFDEUB_AgFrtWz95kQCqtMNu8STLJIAiy1B-waMHqNWQyyTbrTLImM2L_e7PM0qoXTzm8T768xxehZ4CXAKS-2EzjssKYLjEThNEHaAG0FiWphHiIFhgDLxmnzTF6nNIWYyxEA4_QMTAhBOd8gV6vg98Uo4lDYZXrp2iKYAvju5B02DldbFQaY9j1TqvRBV-cXebZynl9c_4EHVnVJ_P08J6gr-8ur1cfyvXn9x9Xb9dlWwMfS2st1JRT3AJULa8AQGvLW0sU7kBXWhGgumusrohtKeYNrzWISgAlWrOOnKA3c-5uagfTaePHqHq5i25Q8VYG5eTfE-9u5Cb8lMA5ZcBywMtDQAw_JpNGObikTd8rb8KUZM0FNEB5hi_-gdswRZ-P22c1hABpIKuLWekYUorG3q0CWO5rkbkWua9FzrXkH8__vODeH3rI4PQAVNKqt1F57dK9qwWtOcHZlbNzaTS_7uYqfs9HEM7kp28red1wdvXlCst19q9m3w7b_275G45psas</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779331391</pqid></control><display><type>article</type><title>Long term failure of endoscopic gastroplication (EndoCinch)</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Schiefke, I ; Zabel-Langhennig, A ; Neumann, S ; Feisthammel, J ; Moessner, J ; Caca, K</creator><creatorcontrib>Schiefke, I ; Zabel-Langhennig, A ; Neumann, S ; Feisthammel, J ; Moessner, J ; Caca, K</creatorcontrib><description>Introduction: Endoluminal gastroplication (EndoCinch; Bard) has been introduced as an endoscopic treatment option in gastro-oesophageal reflux disease (GORD) patients with promising short term results. However, little is known about the long term efficacy of endoscopic suturing. The aim of this study was to evaluate prospectively the long term outcome after EndoCinch. Patients and methods: A total of 70 patients treated with EndoCinch at a single referral centre were studied prospectively. All patients were interviewed using a standardised questionnaire regarding their symptoms and medication prior to and 18 months after EndoCinch. In addition, follow up included endoscopy, 24 hour pH monitoring, and oesophageal manometry. Results: The procedure was well tolerated without major short or long term complications. Eighteen months after EndoCinch, 56/70 patients (80%) were considered treatment failures as their heartburn symptoms did not improve or proton pump inhibitor medication exceeded 50% of the initial dose. Endoscopy showed all sutures in situ in 12/70 (17%) patients while no remaining sutures could be detected in 18/70 (26%). In 54 and 50 patients examined, respectively, no significant changes in 24 hour pH monitoring (median pH <4/24 hours, 9.1% v 8.5%; p = 0.82) or lower oesophageal sphincter (LOS) pressure (7.7 v 10.3 mm Hg; p = 0.051) were observed while median LOS length slightly increased (3.0 to 3.2 cm; p<0.05). Conclusion: Endoscopic gastroplication (EndoCinch) is a safe and minimally invasive endoscopic treatment for GORD with reasonable short term results. In contrast, long term outcome is disappointing, probably due to suture loss in the majority of patients. Therefore, technical improvements to ensure suture durability are mandatory before endoscopic suturing can evolve as a therapeutic option for GORD treatment.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.2004.058354</identifier><identifier>PMID: 15888777</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Acids ; Adult ; Aged ; Biological and medical sciences ; DeMeester-Johnson score ; DMJS ; Dysphagia ; EAT ; EndoCinch ; endoscopic antireflux therapy ; endoscopic gastroplication ; Endoscopy ; Esophagoscopy - methods ; FDA approval ; Female ; Follow-Up Studies ; Fundoplication - methods ; gastro-oesophageal reflux disease ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal reflux ; Gastroesophageal Reflux - drug therapy ; Gastroesophageal Reflux - surgery ; Gastroscopy - methods ; GORD ; H2 receptor antagonist ; H2RA ; HBSS ; Heartburn - drug therapy ; Heartburn - etiology ; Heartburn - surgery ; heartburn severity scoring system ; Hiatal hernias ; Humans ; Hydrogen-Ion Concentration ; interquartile range ; IQR ; Laparoscopy ; LOSP ; lower oesophageal sphincter pressure ; Male ; Manometry ; Medical sciences ; Middle Aged ; Oesophagus ; PPIs ; Prospective Studies ; Proton Pump Inhibitors ; Surgery ; Suture Techniques ; Sutures ; tLOSR ; transient lower oesophageal sphincter relaxation ; Treatment Failure</subject><ispartof>Gut, 2005-06, Vol.54 (6), p.752-758</ispartof><rights>Copyright 2005 by Gut</rights><rights>2005 INIST-CNRS</rights><rights>Copyright: 2005 Copyright 2005 by Gut</rights><rights>Copyright © Copyright 2005 by Gut 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b617t-fff164740b112b72111ccf7bf3a0d1c2ca314cd9fc23fb407976c1828143cc5d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774515/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774515/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16846730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15888777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiefke, I</creatorcontrib><creatorcontrib>Zabel-Langhennig, A</creatorcontrib><creatorcontrib>Neumann, S</creatorcontrib><creatorcontrib>Feisthammel, J</creatorcontrib><creatorcontrib>Moessner, J</creatorcontrib><creatorcontrib>Caca, K</creatorcontrib><title>Long term failure of endoscopic gastroplication (EndoCinch)</title><title>Gut</title><addtitle>Gut</addtitle><description>Introduction: Endoluminal gastroplication (EndoCinch; Bard) has been introduced as an endoscopic treatment option in gastro-oesophageal reflux disease (GORD) patients with promising short term results. However, little is known about the long term efficacy of endoscopic suturing. The aim of this study was to evaluate prospectively the long term outcome after EndoCinch. Patients and methods: A total of 70 patients treated with EndoCinch at a single referral centre were studied prospectively. All patients were interviewed using a standardised questionnaire regarding their symptoms and medication prior to and 18 months after EndoCinch. In addition, follow up included endoscopy, 24 hour pH monitoring, and oesophageal manometry. Results: The procedure was well tolerated without major short or long term complications. Eighteen months after EndoCinch, 56/70 patients (80%) were considered treatment failures as their heartburn symptoms did not improve or proton pump inhibitor medication exceeded 50% of the initial dose. Endoscopy showed all sutures in situ in 12/70 (17%) patients while no remaining sutures could be detected in 18/70 (26%). In 54 and 50 patients examined, respectively, no significant changes in 24 hour pH monitoring (median pH <4/24 hours, 9.1% v 8.5%; p = 0.82) or lower oesophageal sphincter (LOS) pressure (7.7 v 10.3 mm Hg; p = 0.051) were observed while median LOS length slightly increased (3.0 to 3.2 cm; p<0.05). Conclusion: Endoscopic gastroplication (EndoCinch) is a safe and minimally invasive endoscopic treatment for GORD with reasonable short term results. In contrast, long term outcome is disappointing, probably due to suture loss in the majority of patients. Therefore, technical improvements to ensure suture durability are mandatory before endoscopic suturing can evolve as a therapeutic option for GORD treatment.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>DeMeester-Johnson score</subject><subject>DMJS</subject><subject>Dysphagia</subject><subject>EAT</subject><subject>EndoCinch</subject><subject>endoscopic antireflux therapy</subject><subject>endoscopic gastroplication</subject><subject>Endoscopy</subject><subject>Esophagoscopy - methods</subject><subject>FDA approval</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundoplication - methods</subject><subject>gastro-oesophageal reflux disease</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Gastroesophageal Reflux - surgery</subject><subject>Gastroscopy - methods</subject><subject>GORD</subject><subject>H2 receptor antagonist</subject><subject>H2RA</subject><subject>HBSS</subject><subject>Heartburn - drug therapy</subject><subject>Heartburn - etiology</subject><subject>Heartburn - surgery</subject><subject>heartburn severity scoring system</subject><subject>Hiatal hernias</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>interquartile range</subject><subject>IQR</subject><subject>Laparoscopy</subject><subject>LOSP</subject><subject>lower oesophageal sphincter pressure</subject><subject>Male</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oesophagus</subject><subject>PPIs</subject><subject>Prospective Studies</subject><subject>Proton Pump Inhibitors</subject><subject>Surgery</subject><subject>Suture Techniques</subject><subject>Sutures</subject><subject>tLOSR</subject><subject>transient lower oesophageal sphincter relaxation</subject><subject>Treatment Failure</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c9rFDEUB_AgFrtWz95kQCqtMNu8STLJIAiy1B-waMHqNWQyyTbrTLImM2L_e7PM0qoXTzm8T768xxehZ4CXAKS-2EzjssKYLjEThNEHaAG0FiWphHiIFhgDLxmnzTF6nNIWYyxEA4_QMTAhBOd8gV6vg98Uo4lDYZXrp2iKYAvju5B02DldbFQaY9j1TqvRBV-cXebZynl9c_4EHVnVJ_P08J6gr-8ur1cfyvXn9x9Xb9dlWwMfS2st1JRT3AJULa8AQGvLW0sU7kBXWhGgumusrohtKeYNrzWISgAlWrOOnKA3c-5uagfTaePHqHq5i25Q8VYG5eTfE-9u5Cb8lMA5ZcBywMtDQAw_JpNGObikTd8rb8KUZM0FNEB5hi_-gdswRZ-P22c1hABpIKuLWekYUorG3q0CWO5rkbkWua9FzrXkH8__vODeH3rI4PQAVNKqt1F57dK9qwWtOcHZlbNzaTS_7uYqfs9HEM7kp28red1wdvXlCst19q9m3w7b_275G45psas</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Schiefke, I</creator><creator>Zabel-Langhennig, A</creator><creator>Neumann, S</creator><creator>Feisthammel, J</creator><creator>Moessner, J</creator><creator>Caca, K</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>Copyright 2005 by Gut</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050601</creationdate><title>Long term failure of endoscopic gastroplication (EndoCinch)</title><author>Schiefke, I ; Zabel-Langhennig, A ; Neumann, S ; Feisthammel, J ; Moessner, J ; Caca, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b617t-fff164740b112b72111ccf7bf3a0d1c2ca314cd9fc23fb407976c1828143cc5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>DeMeester-Johnson score</topic><topic>DMJS</topic><topic>Dysphagia</topic><topic>EAT</topic><topic>EndoCinch</topic><topic>endoscopic antireflux therapy</topic><topic>endoscopic gastroplication</topic><topic>Endoscopy</topic><topic>Esophagoscopy - methods</topic><topic>FDA approval</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundoplication - methods</topic><topic>gastro-oesophageal reflux disease</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Gastroesophageal Reflux - surgery</topic><topic>Gastroscopy - methods</topic><topic>GORD</topic><topic>H2 receptor antagonist</topic><topic>H2RA</topic><topic>HBSS</topic><topic>Heartburn - drug therapy</topic><topic>Heartburn - etiology</topic><topic>Heartburn - surgery</topic><topic>heartburn severity scoring system</topic><topic>Hiatal hernias</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>interquartile range</topic><topic>IQR</topic><topic>Laparoscopy</topic><topic>LOSP</topic><topic>lower oesophageal sphincter pressure</topic><topic>Male</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oesophagus</topic><topic>PPIs</topic><topic>Prospective Studies</topic><topic>Proton Pump Inhibitors</topic><topic>Surgery</topic><topic>Suture Techniques</topic><topic>Sutures</topic><topic>tLOSR</topic><topic>transient lower oesophageal sphincter relaxation</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiefke, I</creatorcontrib><creatorcontrib>Zabel-Langhennig, A</creatorcontrib><creatorcontrib>Neumann, S</creatorcontrib><creatorcontrib>Feisthammel, J</creatorcontrib><creatorcontrib>Moessner, J</creatorcontrib><creatorcontrib>Caca, K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiefke, I</au><au>Zabel-Langhennig, A</au><au>Neumann, S</au><au>Feisthammel, J</au><au>Moessner, J</au><au>Caca, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long term failure of endoscopic gastroplication (EndoCinch)</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>54</volume><issue>6</issue><spage>752</spage><epage>758</epage><pages>752-758</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>Introduction: Endoluminal gastroplication (EndoCinch; Bard) has been introduced as an endoscopic treatment option in gastro-oesophageal reflux disease (GORD) patients with promising short term results. However, little is known about the long term efficacy of endoscopic suturing. The aim of this study was to evaluate prospectively the long term outcome after EndoCinch. Patients and methods: A total of 70 patients treated with EndoCinch at a single referral centre were studied prospectively. All patients were interviewed using a standardised questionnaire regarding their symptoms and medication prior to and 18 months after EndoCinch. In addition, follow up included endoscopy, 24 hour pH monitoring, and oesophageal manometry. Results: The procedure was well tolerated without major short or long term complications. Eighteen months after EndoCinch, 56/70 patients (80%) were considered treatment failures as their heartburn symptoms did not improve or proton pump inhibitor medication exceeded 50% of the initial dose. Endoscopy showed all sutures in situ in 12/70 (17%) patients while no remaining sutures could be detected in 18/70 (26%). In 54 and 50 patients examined, respectively, no significant changes in 24 hour pH monitoring (median pH <4/24 hours, 9.1% v 8.5%; p = 0.82) or lower oesophageal sphincter (LOS) pressure (7.7 v 10.3 mm Hg; p = 0.051) were observed while median LOS length slightly increased (3.0 to 3.2 cm; p<0.05). Conclusion: Endoscopic gastroplication (EndoCinch) is a safe and minimally invasive endoscopic treatment for GORD with reasonable short term results. In contrast, long term outcome is disappointing, probably due to suture loss in the majority of patients. Therefore, technical improvements to ensure suture durability are mandatory before endoscopic suturing can evolve as a therapeutic option for GORD treatment.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>15888777</pmid><doi>10.1136/gut.2004.058354</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Adult Aged Biological and medical sciences DeMeester-Johnson score DMJS Dysphagia EAT EndoCinch endoscopic antireflux therapy endoscopic gastroplication Endoscopy Esophagoscopy - methods FDA approval Female Follow-Up Studies Fundoplication - methods gastro-oesophageal reflux disease Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal reflux Gastroesophageal Reflux - drug therapy Gastroesophageal Reflux - surgery Gastroscopy - methods GORD H2 receptor antagonist H2RA HBSS Heartburn - drug therapy Heartburn - etiology Heartburn - surgery heartburn severity scoring system Hiatal hernias Humans Hydrogen-Ion Concentration interquartile range IQR Laparoscopy LOSP lower oesophageal sphincter pressure Male Manometry Medical sciences Middle Aged Oesophagus PPIs Prospective Studies Proton Pump Inhibitors Surgery Suture Techniques Sutures tLOSR transient lower oesophageal sphincter relaxation Treatment Failure |
| title | Long term failure of endoscopic gastroplication (EndoCinch) |
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