CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis

Background: CD154/CD40 interactions play a pivotal role both in humoral and cellular immune responses. Their involvement in the pathogenesis of chronic inflammatory bowel disease (IBD) has been revealed by increased expression of CD40 and CD154 in the inflamed mucosa of patients and the therapeutic...

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Veröffentlicht in:	Gut 2005-01, Vol.54 (1), p.70-77
Hauptverfasser:	Gao, D, Wagner, A H, Fankhaenel, S, Stojanovic, T, Schweyer, S, Panzner, S, Hecker, M
Format:	Artikel
Sprache:	eng
Schlagworte:	6-trinitrobenzene sulphonic acid Animals antigen presenting cells Antigens antisense oligonucleotide APC Biological and medical sciences CD40 CD40 Antigens - genetics CD40 Antigens - metabolism CD40 Ligand - metabolism Cell adhesion & migration Cells, Cultured colitis Colitis - chemically induced Colitis - immunology Colitis - prevention & control Colon Crohn Disease - chemically induced Crohn Disease - immunology Crohn Disease - prevention & control Crohn's disease Cytokines Dendritic cells Drug Design EF-2 elongation factor 2 Experiments Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation - immunology IBD ICAM-1 IFN-γ IL-12 Immunity, Mucosal Immunoglobulins Inflammation Inflammatory Bowel Disease Inflammatory diseases intercellular adhesion molecule 1 interferon γ interleukin 12 Intestinal Mucosa - immunology Liposomes Male MCP-1 Medical sciences Molecular weight monocyte chemoatractive protein 1 Muscle, Smooth, Vascular - immunology Muscle, Smooth, Vascular - metabolism ODN oligonucleotide Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - therapeutic use Other diseases. Semiology Pathogenesis RACE rapid amplification of cDNA ends Rats Rats, Wistar reverse transcription-polymerase chain reaction Rodents RT-PCR Smooth muscle Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thromboembolism TNBS TNF-α Transfection trinitrobenzene sulphonic acid Trinitrobenzenesulfonic Acid Tumor necrosis factor-TNF tumour necrosis factor α vascular cell adhesion molecule vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - metabolism vascular smooth muscle cells VCAM-1 VSMC
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