Value of genetic testing in the management of pancreatitis
[...]environmental factors appeared to play a limited role in pancreatic diseases. [...]understanding pancreatic disease has lagged behind advances in other diseases until new genetic methods became available. Recent studies also demonstrated that the pancreatic acinar cells are exquisitely sensitiv...
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| Veröffentlicht in: | Gut 2004-11, Vol.53 (11), p.1710-1717 |
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| container_title | Gut |
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| creator | Whitcomb, D C |
| description | [...]environmental factors appeared to play a limited role in pancreatic diseases. [...]understanding pancreatic disease has lagged behind advances in other diseases until new genetic methods became available. Recent studies also demonstrated that the pancreatic acinar cells are exquisitely sensitive to bile acids. 9 Exposure of the luminal surface of the acinar cell to bile acids causes a marked increase in intracellular calcium, and therefore may also cause acute pancreatitis through a calcium dependent mechanism, as described below. |
| doi_str_mv | 10.1136/gut.2003.015511 |
| format | Article |
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[...]understanding pancreatic disease has lagged behind advances in other diseases until new genetic methods became available. Recent studies also demonstrated that the pancreatic acinar cells are exquisitely sensitive to bile acids. 9 Exposure of the luminal surface of the acinar cell to bile acids causes a marked increase in intracellular calcium, and therefore may also cause acute pancreatitis through a calcium dependent mechanism, as described below.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.2003.015511</identifier><identifier>PMID: 15479696</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Acute Disease ; acute pancreatitis ; anionic trypsinogen ; Biological and medical sciences ; Carrier Proteins - genetics ; cationic trypsinogen ; CFTR ; Chronic Disease ; chronic pancreatitis ; Counseling ; Cystic fibrosis ; Cystic Fibrosis Transmembrane Conductance Regulator - genetics ; Disease ; familial pancreatitis ; Gastroenterology. Liver. Pancreas. Abdomen ; Genes ; Genetic Predisposition to Disease ; Genetic testing ; Genetic Testing - methods ; hereditary pancreatitis ; Humans ; Immunology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mutation ; Other diseases. Semiology ; Pancreas ; pancreatic secretory trypsin inhibitor ; Pancreatitis - diagnosis ; Pancreatitis - genetics ; PRSS1 ; PRSS2 ; Recent Advances in Clinical Practice ; recurrent acute pancreatitis ; Rodents ; SPINK1 ; Trypsin Inhibitor, Kazal Pancreatic ; Trypsinogen - genetics ; UTG1A7</subject><ispartof>Gut, 2004-11, Vol.53 (11), p.1710-1717</ispartof><rights>Copyright 2004 by Gut</rights><rights>2005 INIST-CNRS</rights><rights>Copyright: 2004 Copyright 2004 by Gut</rights><rights>Copyright © Copyright 2004 by Gut 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b586t-52bbdcea9cb9549d2b74118495d8c0ec1e5c691370050d2663e0c9d579b9b6543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774302/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774302/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16227603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15479696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitcomb, D C</creatorcontrib><title>Value of genetic testing in the management of pancreatitis</title><title>Gut</title><addtitle>Gut</addtitle><description>[...]environmental factors appeared to play a limited role in pancreatic diseases. [...]understanding pancreatic disease has lagged behind advances in other diseases until new genetic methods became available. Recent studies also demonstrated that the pancreatic acinar cells are exquisitely sensitive to bile acids. 9 Exposure of the luminal surface of the acinar cell to bile acids causes a marked increase in intracellular calcium, and therefore may also cause acute pancreatitis through a calcium dependent mechanism, as described below.</description><subject>Acute Disease</subject><subject>acute pancreatitis</subject><subject>anionic trypsinogen</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>cationic trypsinogen</subject><subject>CFTR</subject><subject>Chronic Disease</subject><subject>chronic pancreatitis</subject><subject>Counseling</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis Transmembrane Conductance Regulator - genetics</subject><subject>Disease</subject><subject>familial pancreatitis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic testing</subject><subject>Genetic Testing - methods</subject><subject>hereditary pancreatitis</subject><subject>Humans</subject><subject>Immunology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Other diseases. Semiology</subject><subject>Pancreas</subject><subject>pancreatic secretory trypsin inhibitor</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - genetics</subject><subject>PRSS1</subject><subject>PRSS2</subject><subject>Recent Advances in Clinical Practice</subject><subject>recurrent acute pancreatitis</subject><subject>Rodents</subject><subject>SPINK1</subject><subject>Trypsin Inhibitor, Kazal Pancreatic</subject><subject>Trypsinogen - genetics</subject><subject>UTG1A7</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c1rFDEYBvAgit1Wz95kQOxBmO2b70kPgqyfWFRQ9xoymew260xmTTKi_71ZZmnVi6cc8stD3vdB6BGGJcZUXGynvCQAdAmYc4zvoAVmoqkpaZq7aAGAZc0lUyfoNKUdADSNwvfRCeZMKqHEAl2uTT-5atxUWxdc9rbKLmUftpUPVb521WCC2brBhXxAexNsdCb77NMDdG9j-uQeHs8z9PX1qy-rt_XVxzfvVi-u6pY3ItectG1nnVG2VZypjrSSYdwwxbvGgrPYcSsUphKAQ0eEoA6s6rhUrWoFZ_QMPZ9z91M7uBIVcjS93kc_mPhLj8brv2-Cv9bb8YfGUjIKpAScHwPi-H0q4-nBJ-v63gQ3TkmLsgnBgBf45B-4G6cYynCHLEUJA9IUdTErG8eUotvcfAWDPrSiSyv60IqeWykvHv85wa0_1lDA0yMwyZp-E8uafbp1ghApgBZXz86n7H7e3Jv4TQtJJdcf1itN1MvPn_Ca6_fFP5t9O-z--8vfLmWwwA</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Whitcomb, D C</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>Copyright 2004 by Gut</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20041101</creationdate><title>Value of genetic testing in the management of pancreatitis</title><author>Whitcomb, D C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b586t-52bbdcea9cb9549d2b74118495d8c0ec1e5c691370050d2663e0c9d579b9b6543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute Disease</topic><topic>acute pancreatitis</topic><topic>anionic trypsinogen</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>cationic trypsinogen</topic><topic>CFTR</topic><topic>Chronic Disease</topic><topic>chronic pancreatitis</topic><topic>Counseling</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis Transmembrane Conductance Regulator - genetics</topic><topic>Disease</topic><topic>familial pancreatitis</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic testing</topic><topic>Genetic Testing - methods</topic><topic>hereditary pancreatitis</topic><topic>Humans</topic><topic>Immunology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Other diseases. Semiology</topic><topic>Pancreas</topic><topic>pancreatic secretory trypsin inhibitor</topic><topic>Pancreatitis - diagnosis</topic><topic>Pancreatitis - genetics</topic><topic>PRSS1</topic><topic>PRSS2</topic><topic>Recent Advances in Clinical Practice</topic><topic>recurrent acute pancreatitis</topic><topic>Rodents</topic><topic>SPINK1</topic><topic>Trypsin Inhibitor, Kazal Pancreatic</topic><topic>Trypsinogen - genetics</topic><topic>UTG1A7</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitcomb, D C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitcomb, D C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of genetic testing in the management of pancreatitis</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>53</volume><issue>11</issue><spage>1710</spage><epage>1717</epage><pages>1710-1717</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>[...]environmental factors appeared to play a limited role in pancreatic diseases. [...]understanding pancreatic disease has lagged behind advances in other diseases until new genetic methods became available. Recent studies also demonstrated that the pancreatic acinar cells are exquisitely sensitive to bile acids. 9 Exposure of the luminal surface of the acinar cell to bile acids causes a marked increase in intracellular calcium, and therefore may also cause acute pancreatitis through a calcium dependent mechanism, as described below.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>15479696</pmid><doi>10.1136/gut.2003.015511</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease acute pancreatitis anionic trypsinogen Biological and medical sciences Carrier Proteins - genetics cationic trypsinogen CFTR Chronic Disease chronic pancreatitis Counseling Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Disease familial pancreatitis Gastroenterology. Liver. Pancreas. Abdomen Genes Genetic Predisposition to Disease Genetic testing Genetic Testing - methods hereditary pancreatitis Humans Immunology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mutation Other diseases. Semiology Pancreas pancreatic secretory trypsin inhibitor Pancreatitis - diagnosis Pancreatitis - genetics PRSS1 PRSS2 Recent Advances in Clinical Practice recurrent acute pancreatitis Rodents SPINK1 Trypsin Inhibitor, Kazal Pancreatic Trypsinogen - genetics UTG1A7 |
| title | Value of genetic testing in the management of pancreatitis |
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