Interleukin 1β induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection

Background and aims: Matrix metalloproteinases (MMPs) are endopeptidases with roles in extracellular matrix remodelling, cell proliferation, and inflammatory processes. We showed previously that Helicobacter pylori infection of human gastric adenocarcinoma (AGS) cells increased epithelial secretion...

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Veröffentlicht in:	Gut 2003-09, Vol.52 (9), p.1250-1256
Hauptverfasser:	Gööz, M, Shaker, M, Gööz, P, Smolka, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences cagA cytotoxin associated protein Development and progression ELISA enzyme linked immunosorbent assay gastric inflammation Helicobacter infections Helicobacter pylori Human bacterial diseases Infectious diseases interleukin interleukin 1β Interleukin-1 matrix metalloproteinase matrix metalloproteinases Medical sciences Metalloenzymes MMPs MOI multiplicity of infection PBS phosphate buffered saline Physiological aspects SDS-PAGE sodium dodecyl sulphate-polyacrylamide gel electrophoresis Stomach TIMP tissue inhibitor of metalloproteinases TNF-α tumour necrosis factor α vacA vacuolating cytotoxin
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