Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats

Background and aims: The role of sensory neurones in colitis was studied by chemical denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 (VR-1) in rats prior to administration of dextran sulphate sodium (DSS) to induce colitis. Methods: Neonatal rats were chemic...

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Veröffentlicht in:	Gut 2003-05, Vol.52 (5), p.713-719
Hauptverfasser:	Kihara, N, de la Fuente, S G, Fujino, K, Takahashi, T, Pappas, T N, Mantyh, C R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Biological and medical sciences calcitonin gene related peptide capsaicin Capsaicin - analogs & derivatives Capsaicin - pharmacology capsazepine CGRP Colitis Colitis, Ulcerative - chemically induced Colitis, Ulcerative - pathology Colitis, Ulcerative - prevention & control Colon Colon - drug effects Colon - innervation Colon - pathology CPZ DAI Denervation - methods Dextran Sulfate dextran sulphate sodium disease activity index Disease Models, Animal DSS Ethanol Gastroenterology. Liver. Pancreas. Abdomen H&E haematoxylin and eosin hexadecyltrimethyllammonium bromide HTAB Inflammation Inflammatory Bowel Disease Investigations Laboratories Medical sciences Molecular weight MPO myleoperoxidase Nervous system Neurons Neurons, Afferent - physiology Other diseases. Semiology Peptides Peroxidase - metabolism Physiological aspects Propagation Rats Rats as laboratory animals Rats, Sprague-Dawley Receptors, Drug - antagonists & inhibitors Rodents sensory neurones Severity of Illness Index Stomach. Duodenum. Small intestine. Colon. Rectum. Anus substance P TRPV Cation Channels vanilloid receptor vanilloid receptor subtype-1 VR-1
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