Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia

Background: Adaptive colonic phenotypic change of the ileal mucosa is a feature of the ileoanal reservoir (IAR) with time, as described by mucin glycoprotein and histological analysis. Mucin gene expression is altered in colorectal neoplasia and inflammatory bowel disease but little is known of its...

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Veröffentlicht in:	Gut 2002-09, Vol.51 (3), p.386-391
Hauptverfasser:	Sylvester, P A, Walsh, M, Myerscough, N, Warren, B F, Corfield, A P, Thomas, M G, Durdey, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biopsy Child Child, Preschool colonic phenotypic change Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Digestive system dysplasia Ethics familial adenomatous polyposis FAP Gene expression Gene Expression - genetics Genetic aspects Humans IAR ileoanal reservoir Ileum Immunoglobulins Immunohistochemistry In Situ Hybridization Infant Inflammation Inflammation and Inflammatory Bowel Disease Inflammatory bowel disease Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Morphology mucin gene Mucins Mucins - genetics Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques PBS Peptides phosphate buffered saline Physiological aspects Proctocolectomy, Restorative RNA, Messenger - analysis Studies Surveillance UACL ulcer associated cell lineage ulcerative colitis variable number tandem repeat VNTR
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