Protective role of oral antioxidant supplementation in ocular surface of diabetic patients
Aim: To investigate the effect of vitamin C and E supplementation in the levels of nitrite, nitric oxide (NO) related metabolite, and ocular surface parameters in diabetic patients. Methods: 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (40...
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| Veröffentlicht in: | British journal of ophthalmology 2002-12, Vol.86 (12), p.1369-1373 |
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| creator | Peponis, V Papathanasiou, M Kapranou, A Magkou, C Tyligada, A Melidonis, A Drosos, T Sitaras, N M |
| description | Aim: To investigate the effect of vitamin C and E supplementation in the levels of nitrite, nitric oxide (NO) related metabolite, and ocular surface parameters in diabetic patients. Methods: 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) supplementation for 10 days. Nitrite levels in tears were measured by photometric determination before and after vitamin supplementation. Tear function parameters (Schirmer test I, BUT, ocular ferning test) and brush cytology analysis of the conjunctival epithelium were also evaluated. Results: Nitrite levels were found to be significantly reduced (p |
| doi_str_mv | 10.1136/bjo.86.12.1369 |
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Methods: 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) supplementation for 10 days. Nitrite levels in tears were measured by photometric determination before and after vitamin supplementation. Tear function parameters (Schirmer test I, BUT, ocular ferning test) and brush cytology analysis of the conjunctival epithelium were also evaluated. Results: Nitrite levels were found to be significantly reduced (p<0.05) after 10 days of vitamin C and E supplementation. Improved values for Schirmer test, BUT test, and ocular ferning test were also found. Goblet cell density and grading of squamous metaplasia showed a significant improvement. Conclusions: Oxidative stress and free radical production are elevated in diabetes mellitus. Antioxidants, such as vitamin C and vitamin E, probably have an important role in reducing the oxidative damage produced by nitric oxide and other free radicals and improving the ocular surface milieu.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.86.12.1369</identifier><identifier>PMID: 12446368</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Administration, Oral ; Aged ; antioxidant vitamins ; Ascorbic Acid - administration & dosage ; Associated diseases and complications ; Biological and medical sciences ; brush cytology ; Clinical Science ; Complications and side effects ; Conjunctiva - drug effects ; Conjunctiva - metabolism ; Conjunctiva - pathology ; Diabetes ; diabetes mellitus ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Diabetic neuropathy ; Diabetic retinopathy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Family medical history ; Female ; Humans ; Investigations ; Male ; Medical sciences ; Metaplasia ; Middle Aged ; Nitric oxide ; Nitric Oxide - analysis ; Nitrites - analysis ; Ophthalmology ; Tears - chemistry ; Vitamin C ; Vitamin E ; Vitamin E - administration & dosage</subject><ispartof>British journal of ophthalmology, 2002-12, Vol.86 (12), p.1369-1373</ispartof><rights>Copyright 2002 British Journal of Ophthalmology</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2002 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2002 Copyright 2002 British Journal of Ophthalmology</rights><rights>Copyright © Copyright 2002 British Journal of Ophthalmology 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b618t-4ae827a35e625b7294e9a53f326d597c60e35729a923c54904b5ac6c15a5fb5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771432/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1771432/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14027730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12446368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peponis, V</creatorcontrib><creatorcontrib>Papathanasiou, M</creatorcontrib><creatorcontrib>Kapranou, A</creatorcontrib><creatorcontrib>Magkou, C</creatorcontrib><creatorcontrib>Tyligada, A</creatorcontrib><creatorcontrib>Melidonis, A</creatorcontrib><creatorcontrib>Drosos, T</creatorcontrib><creatorcontrib>Sitaras, N M</creatorcontrib><title>Protective role of oral antioxidant supplementation in ocular surface of diabetic patients</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Aim: To investigate the effect of vitamin C and E supplementation in the levels of nitrite, nitric oxide (NO) related metabolite, and ocular surface parameters in diabetic patients. Methods: 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) supplementation for 10 days. Nitrite levels in tears were measured by photometric determination before and after vitamin supplementation. Tear function parameters (Schirmer test I, BUT, ocular ferning test) and brush cytology analysis of the conjunctival epithelium were also evaluated. Results: Nitrite levels were found to be significantly reduced (p<0.05) after 10 days of vitamin C and E supplementation. Improved values for Schirmer test, BUT test, and ocular ferning test were also found. Goblet cell density and grading of squamous metaplasia showed a significant improvement. Conclusions: Oxidative stress and free radical production are elevated in diabetes mellitus. Antioxidants, such as vitamin C and vitamin E, probably have an important role in reducing the oxidative damage produced by nitric oxide and other free radicals and improving the ocular surface milieu.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>antioxidant vitamins</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>brush cytology</subject><subject>Clinical Science</subject><subject>Complications and side effects</subject><subject>Conjunctiva - drug effects</subject><subject>Conjunctiva - metabolism</subject><subject>Conjunctiva - pathology</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic neuropathy</subject><subject>Diabetic retinopathy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Family medical history</subject><subject>Female</subject><subject>Humans</subject><subject>Investigations</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>Nitrites - analysis</subject><subject>Ophthalmology</subject><subject>Tears - chemistry</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamin E - administration & dosage</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt-LEzEQx4MoXq2--iiLh4Lg1vzYJJsX4aieCof6oEXuJWTTbE3dTWqye5z_vVNbrqcUJA9DZj7znR8MQo8JnhHCxKtmHWe1mBE6g5-6gyakEnVJsVR30QRjLEtCBDlBD3Jew5cKIu-jE0KrSjBRT9Dl5xQHZwd_5YoUO1fEtojJdIUJg4_Xfgm2yONm07nehcGAMxQ-FNGOnUkQSa2xf7KW3jRu8LbYAARofojutabL7tHeTtHX87df5u_Li0_vPszPLspGkHooK-NqKg3jTlDeSKoqpwxnLaNiyZW0AjvGwW0UZZZXClcNN1ZYwg1vG96wKXq9092MTe-WFmrDAHqTfG_SLx2N139Hgv-uV_FKEylJxSgIPN8LpPhzdHnQvc_WdZ0JLo5ZSyppTWsF4Ok_4DqOKcBwWy2FsZKcAPV0R61M57QPbYSqdiupzxSHxSuoOkUvj0ArFxx0GINrPbhv4-URHN7S9d4e42c73qaYc3LtzToI1tvD0XA4uhaaUL09HEh4cnuJB3x_KQA82wMmW9O1yQTr84GrMJWS4UOnPg_u-iZu0g8tJJNcf1zMdfXtjVic00u9AP7Fjm_69f-a_A0rn-dW</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Peponis, V</creator><creator>Papathanasiou, M</creator><creator>Kapranou, A</creator><creator>Magkou, C</creator><creator>Tyligada, A</creator><creator>Melidonis, A</creator><creator>Drosos, T</creator><creator>Sitaras, N M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>Copyright 2002 British Journal of Ophthalmology</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20021201</creationdate><title>Protective role of oral antioxidant supplementation in ocular surface of diabetic patients</title><author>Peponis, V ; Papathanasiou, M ; Kapranou, A ; Magkou, C ; Tyligada, A ; Melidonis, A ; Drosos, T ; Sitaras, N M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b618t-4ae827a35e625b7294e9a53f326d597c60e35729a923c54904b5ac6c15a5fb5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>antioxidant vitamins</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>brush cytology</topic><topic>Clinical Science</topic><topic>Complications and side effects</topic><topic>Conjunctiva - drug effects</topic><topic>Conjunctiva - metabolism</topic><topic>Conjunctiva - pathology</topic><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic neuropathy</topic><topic>Diabetic retinopathy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Family medical history</topic><topic>Female</topic><topic>Humans</topic><topic>Investigations</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>Nitrites - analysis</topic><topic>Ophthalmology</topic><topic>Tears - chemistry</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peponis, V</creatorcontrib><creatorcontrib>Papathanasiou, M</creatorcontrib><creatorcontrib>Kapranou, A</creatorcontrib><creatorcontrib>Magkou, C</creatorcontrib><creatorcontrib>Tyligada, A</creatorcontrib><creatorcontrib>Melidonis, A</creatorcontrib><creatorcontrib>Drosos, T</creatorcontrib><creatorcontrib>Sitaras, N M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peponis, V</au><au>Papathanasiou, M</au><au>Kapranou, A</au><au>Magkou, C</au><au>Tyligada, A</au><au>Melidonis, A</au><au>Drosos, T</au><au>Sitaras, N M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective role of oral antioxidant supplementation in ocular surface of diabetic patients</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>86</volume><issue>12</issue><spage>1369</spage><epage>1373</epage><pages>1369-1373</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Aim: To investigate the effect of vitamin C and E supplementation in the levels of nitrite, nitric oxide (NO) related metabolite, and ocular surface parameters in diabetic patients. Methods: 50 patients with non-insulin dependent diabetes mellitus were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) supplementation for 10 days. Nitrite levels in tears were measured by photometric determination before and after vitamin supplementation. Tear function parameters (Schirmer test I, BUT, ocular ferning test) and brush cytology analysis of the conjunctival epithelium were also evaluated. Results: Nitrite levels were found to be significantly reduced (p<0.05) after 10 days of vitamin C and E supplementation. Improved values for Schirmer test, BUT test, and ocular ferning test were also found. Goblet cell density and grading of squamous metaplasia showed a significant improvement. Conclusions: Oxidative stress and free radical production are elevated in diabetes mellitus. Antioxidants, such as vitamin C and vitamin E, probably have an important role in reducing the oxidative damage produced by nitric oxide and other free radicals and improving the ocular surface milieu.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>12446368</pmid><doi>10.1136/bjo.86.12.1369</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Aged antioxidant vitamins Ascorbic Acid - administration & dosage Associated diseases and complications Biological and medical sciences brush cytology Clinical Science Complications and side effects Conjunctiva - drug effects Conjunctiva - metabolism Conjunctiva - pathology Diabetes diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diabetic neuropathy Diabetic retinopathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Family medical history Female Humans Investigations Male Medical sciences Metaplasia Middle Aged Nitric oxide Nitric Oxide - analysis Nitrites - analysis Ophthalmology Tears - chemistry Vitamin C Vitamin E Vitamin E - administration & dosage |
| title | Protective role of oral antioxidant supplementation in ocular surface of diabetic patients |
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