Sarcoidosis and HTLV-1 infection
An asymptomatic, homosexual, white man was found to have an abnormal chest x ray. A presumptive diagnosis of sarcoidosis was made, but pulmonary function tests and a transbronchial biopsy were normal. He then remained asymptomatic for 10 years until he developed a progressive spastic paraparesis. At...
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| Veröffentlicht in: | Journal of clinical pathology 2005-09, Vol.58 (9), p.996-997 |
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| container_title | Journal of clinical pathology |
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| creator | McKee, D H Young, A C Haeney, M |
| description | An asymptomatic, homosexual, white man was found to have an abnormal chest x ray. A presumptive diagnosis of sarcoidosis was made, but pulmonary function tests and a transbronchial biopsy were normal. He then remained asymptomatic for 10 years until he developed a progressive spastic paraparesis. At this point, antibodies to human T cell lymphotropic virus type 1 (HTLV-1) were identified in the serum and cerebrospinal fluid, and the diagnosis of HTLV-1 associated myelopathy was made, the history suggesting sexual exposure to HTLV-1 many years previously. HTLV-1 is associated with a spectrum of immune related disorders, including a pulmonary sarcoid-like syndrome. Infection with this chronic proinflammatory retrovirus should be considered in the differential diagnosis of all immune disorders in at risk individuals. |
| doi_str_mv | 10.1136/jcp.2004.022715 |
| format | Article |
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A presumptive diagnosis of sarcoidosis was made, but pulmonary function tests and a transbronchial biopsy were normal. He then remained asymptomatic for 10 years until he developed a progressive spastic paraparesis. At this point, antibodies to human T cell lymphotropic virus type 1 (HTLV-1) were identified in the serum and cerebrospinal fluid, and the diagnosis of HTLV-1 associated myelopathy was made, the history suggesting sexual exposure to HTLV-1 many years previously. HTLV-1 is associated with a spectrum of immune related disorders, including a pulmonary sarcoid-like syndrome. Infection with this chronic proinflammatory retrovirus should be considered in the differential diagnosis of all immune disorders in at risk individuals.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2004.022715</identifier><identifier>PMID: 16126888</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>ACE ; angiotensin converting enzyme ; Antiretroviral drugs ; Biopsy ; Case Reports ; cerebrospinal fluid ; CSF ; Deoxyribonucleic acid ; DNA ; HAM ; HIV ; HTLV-1 ; HTLV-I Infections - complications ; HTLV-I Infections - diagnosis ; HTLV-I Infections - transmission ; Human immunodeficiency virus ; human T cell lymphotropic virus type 1 ; human T cell lymphotropic virus type 1 associated myelopathy ; Humans ; Immunoglobulins ; Infections ; Lymphocytes ; Male ; Middle Aged ; Polymerase chain reaction ; Radiography ; Sarcoidosis ; Sarcoidosis, Pulmonary - diagnostic imaging ; Sarcoidosis, Pulmonary - virology ; tropical spastic paraparesis ; TSP</subject><ispartof>Journal of clinical pathology, 2005-09, Vol.58 (9), p.996-997</ispartof><rights>Copyright 2005 Journal of Clinical Pathology</rights><rights>Copyright: 2005 Copyright 2005 Journal of Clinical Pathology</rights><rights>Copyright © Copyright 2005 Journal of Clinical Pathology 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770837/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770837/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16126888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKee, D H</creatorcontrib><creatorcontrib>Young, A C</creatorcontrib><creatorcontrib>Haeney, M</creatorcontrib><title>Sarcoidosis and HTLV-1 infection</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>An asymptomatic, homosexual, white man was found to have an abnormal chest x ray. A presumptive diagnosis of sarcoidosis was made, but pulmonary function tests and a transbronchial biopsy were normal. He then remained asymptomatic for 10 years until he developed a progressive spastic paraparesis. At this point, antibodies to human T cell lymphotropic virus type 1 (HTLV-1) were identified in the serum and cerebrospinal fluid, and the diagnosis of HTLV-1 associated myelopathy was made, the history suggesting sexual exposure to HTLV-1 many years previously. HTLV-1 is associated with a spectrum of immune related disorders, including a pulmonary sarcoid-like syndrome. Infection with this chronic proinflammatory retrovirus should be considered in the differential diagnosis of all immune disorders in at risk individuals.</description><subject>ACE</subject><subject>angiotensin converting enzyme</subject><subject>Antiretroviral drugs</subject><subject>Biopsy</subject><subject>Case Reports</subject><subject>cerebrospinal fluid</subject><subject>CSF</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>HAM</subject><subject>HIV</subject><subject>HTLV-1</subject><subject>HTLV-I Infections - complications</subject><subject>HTLV-I Infections - diagnosis</subject><subject>HTLV-I Infections - transmission</subject><subject>Human immunodeficiency virus</subject><subject>human T cell lymphotropic virus type 1</subject><subject>human T cell lymphotropic virus type 1 associated myelopathy</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Radiography</subject><subject>Sarcoidosis</subject><subject>Sarcoidosis, Pulmonary - diagnostic imaging</subject><subject>Sarcoidosis, Pulmonary - virology</subject><subject>tropical spastic paraparesis</subject><subject>TSP</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc9LwzAYhoMobk7P3qQgeBA6kzRN0osgRTel6ME5vIW0TTW1a2bTiv73pnT-POXwPTx5v-8F4BDBKUIBPSuz9RRDSKYQY4bCLTBGhGGfIEK3wRhCjPyIEToCe9aWEKKAoWAXjBBFmHLOx8C7l01mdG6stp6sc2--SJY-8nRdqKzVpt4HO4WsrDrYvBPwcHW5iOd-cje7ji8SPyWQtj7nmKhQFTjLWF4UmEURi2gUKUkkowpmBOcSFhFkKk3zXDqMyjBIwxSnjLtUE3A-eNddulJ5puq2kZVYN3olmw9hpBZ_J7V-Fk_mTSDGIA-YE5xsBI157ZRtxUrbTFWVrJXprKA87Hfufzr-B5ama2q3nHNxBHHoUjrq6Hee7yBfp3OAPwDatur9ey6bF0FZwEJxu4zFDD7eJCQOROz404FPV-WPDYq-R-F6FH2PYugx-AQxCIt0</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>McKee, D H</creator><creator>Young, A C</creator><creator>Haeney, M</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group LTD</general><general>Copyright 2005 Journal of Clinical Pathology</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200509</creationdate><title>Sarcoidosis and HTLV-1 infection</title><author>McKee, D H ; Young, A C ; Haeney, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b406t-8824e5ef2cc7dff279979699ea4a76e0c42da0f907ebbddacc76a53b5b2b78713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ACE</topic><topic>angiotensin converting enzyme</topic><topic>Antiretroviral drugs</topic><topic>Biopsy</topic><topic>Case Reports</topic><topic>cerebrospinal fluid</topic><topic>CSF</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>HAM</topic><topic>HIV</topic><topic>HTLV-1</topic><topic>HTLV-I Infections - complications</topic><topic>HTLV-I Infections - diagnosis</topic><topic>HTLV-I Infections - transmission</topic><topic>Human immunodeficiency virus</topic><topic>human T cell lymphotropic virus type 1</topic><topic>human T cell lymphotropic virus type 1 associated myelopathy</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Radiography</topic><topic>Sarcoidosis</topic><topic>Sarcoidosis, Pulmonary - diagnostic imaging</topic><topic>Sarcoidosis, Pulmonary - virology</topic><topic>tropical spastic paraparesis</topic><topic>TSP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKee, D H</creatorcontrib><creatorcontrib>Young, A C</creatorcontrib><creatorcontrib>Haeney, M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKee, D H</au><au>Young, A C</au><au>Haeney, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sarcoidosis and HTLV-1 infection</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2005-09</date><risdate>2005</risdate><volume>58</volume><issue>9</issue><spage>996</spage><epage>997</epage><pages>996-997</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>An asymptomatic, homosexual, white man was found to have an abnormal chest x ray. 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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | ACE angiotensin converting enzyme Antiretroviral drugs Biopsy Case Reports cerebrospinal fluid CSF Deoxyribonucleic acid DNA HAM HIV HTLV-1 HTLV-I Infections - complications HTLV-I Infections - diagnosis HTLV-I Infections - transmission Human immunodeficiency virus human T cell lymphotropic virus type 1 human T cell lymphotropic virus type 1 associated myelopathy Humans Immunoglobulins Infections Lymphocytes Male Middle Aged Polymerase chain reaction Radiography Sarcoidosis Sarcoidosis, Pulmonary - diagnostic imaging Sarcoidosis, Pulmonary - virology tropical spastic paraparesis TSP |
| title | Sarcoidosis and HTLV-1 infection |
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