Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumour and malignant triton tumour: a cytogenetic and molecular cytogenetic study

Background: Cytogenetic studies of malignant peripheral nerve sheath tumours (MPNSTs) and malignant triton tumours (MTTs) are rare. Aims: To undertake cytogenetic analysis of these tumours. Methods: Conventional cytogenetic analysis of 21 MPNSTs and MTTs from 17 patients (nine with peripheral neurof...

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Veröffentlicht in:	Journal of clinical pathology 2004-11, Vol.57 (11), p.1172-1178
Hauptverfasser:	Bridge, R S, Bridge, J A, Neff, J R, Naumann, S, Althof, P, Bruch, L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Cell Transformation, Neoplastic - genetics Chromosome Aberrations Chromosome Deletion Chromosomes cytogenetic Cytogenetics EGFR epidermal growth factor receptor ERK extracellular signal regulated kinase Female FISH fluorescent in situ hybridisation Gene Amplification - genetics Humans In Situ Hybridization, Fluorescence - methods Karyotyping - methods Kinases Male malignant peripheral nerve sheath tumour malignant triton tumour Middle Aged MPNST MTT Musculoskeletal system Nerve Sheath Neoplasms - genetics neurofibromatosis Neurofibromatosis 1 - genetics Original Pathogenesis reverse transcription polymerase chain reaction Rhabdomyosarcoma - genetics RT-PCR Signal transduction SKY spectral karyotypic analysis Translocation, Genetic - genetics Tumors
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