A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus
This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed...
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| Veröffentlicht in: | Journal of clinical pathology 2004-09, Vol.57 (9), p.991-992 |
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| creator | Callister, M E Griffiths, M J Nicholson, A G Leonard, A Johnson, E M Polkey, M I Kerr, J R |
| description | This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granulomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1–D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection. |
| doi_str_mv | 10.1136/jcp.2003.014449 |
| format | Article |
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Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granulomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1–D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2003.014449</identifier><identifier>PMID: 15333665</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adult ; aspergillosis ; Aspergillosis - diagnosis ; Aspergillus fumigatus ; Aspergillus fumigatus - isolation & purification ; Aspergillus fumigatus - physiology ; Biological and medical sciences ; Case Reports ; Fatal Outcome ; Female ; Human mycoses ; Humans ; Infectious diseases ; Investigative techniques, diagnostic techniques (general aspects) ; Liver - microbiology ; Lung Diseases, Fungal - diagnosis ; Lymph Nodes - microbiology ; Medical sciences ; Miscellaneous mycoses ; Mycological Typing Techniques ; Mycoses ; non-sporing ; non-sporulating ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pregnancy ; Pregnancy Complications, Infectious - diagnosis ; Spleen - microbiology ; Spores, Fungal</subject><ispartof>Journal of clinical pathology, 2004-09, Vol.57 (9), p.991-992</ispartof><rights>Copyright 2004 Journal of Clinical Pathology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright: 2004 Copyright 2004 Journal of Clinical Pathology</rights><rights>Copyright © Copyright 2004 Journal of Clinical Pathology 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770428/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770428/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16119745$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15333665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Callister, M E</creatorcontrib><creatorcontrib>Griffiths, M J</creatorcontrib><creatorcontrib>Nicholson, A G</creatorcontrib><creatorcontrib>Leonard, A</creatorcontrib><creatorcontrib>Johnson, E M</creatorcontrib><creatorcontrib>Polkey, M I</creatorcontrib><creatorcontrib>Kerr, J R</creatorcontrib><title>A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granulomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1–D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection.</description><subject>Adult</subject><subject>aspergillosis</subject><subject>Aspergillosis - diagnosis</subject><subject>Aspergillus fumigatus</subject><subject>Aspergillus fumigatus - isolation & purification</subject><subject>Aspergillus fumigatus - physiology</subject><subject>Biological and medical sciences</subject><subject>Case Reports</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver - microbiology</subject><subject>Lung Diseases, Fungal - diagnosis</subject><subject>Lymph Nodes - microbiology</subject><subject>Medical sciences</subject><subject>Miscellaneous mycoses</subject><subject>Mycological Typing Techniques</subject><subject>Mycoses</subject><subject>non-sporing</subject><subject>non-sporulating</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - diagnosis</subject><subject>Spleen - microbiology</subject><subject>Spores, Fungal</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAUhoMo7rh67Z0URC-EjvnqSXOzMIyuHyx-od6G0zQdM7ZpbVpx_70pM7ur3ngVyHnycMj7EvKQ0TVjAp7v7bDmlIo1ZVJKfYusmFQ8l0zCbbKilLNcKwkn5F6Me0qZUEzcJSesEEIAFCvSbLIGJ2wzi9FlfZPVPkbX-YCTqzOMgxt3vm376GNC5pguq8sMs9CHPA79OLc4-bDL4jSiD4tgc_Vmjlkzd36H0xzvkzsNttE9OJ6n5Mv5y8_b1_nF-1dvtpuLvJJQTHmB1BaKQl0DliU43VQOsRRodcm5hkpxAKmV5pw7VdWloqWzVOma15Y1IE7J2cE7zFXnautC2qs1w-g7HC9Nj978PQn-m9n1Pw1TikpeJsHTo2Dsf8wuTqbz0bq2xeD6ORqAkgOn6r9gEmotgSXw8T_gvp_HkH4hMSWjPIVVJOrRn4tfb3yVVAKeHAGMFttmxGB9vOGAsZT0wuUHzsfJ_bqe4_jdgBKqMO--bs2nDxrO3774aBb-2YGvuv2NjZqlXibVyyz1Mod6id89Q7_y</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Callister, M E</creator><creator>Griffiths, M J</creator><creator>Nicholson, A G</creator><creator>Leonard, A</creator><creator>Johnson, E M</creator><creator>Polkey, M I</creator><creator>Kerr, J R</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>Copyright 2004 Journal of Clinical Pathology</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040901</creationdate><title>A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus</title><author>Callister, M E ; Griffiths, M J ; Nicholson, A G ; Leonard, A ; Johnson, E M ; Polkey, M I ; Kerr, J R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b465t-5a0c5706dd6a886e9fbeaa83ac982296b72664979222e7bd8708ec079d2dc1f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>aspergillosis</topic><topic>Aspergillosis - diagnosis</topic><topic>Aspergillus fumigatus</topic><topic>Aspergillus fumigatus - isolation & purification</topic><topic>Aspergillus fumigatus - physiology</topic><topic>Biological and medical sciences</topic><topic>Case Reports</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver - microbiology</topic><topic>Lung Diseases, Fungal - diagnosis</topic><topic>Lymph Nodes - microbiology</topic><topic>Medical sciences</topic><topic>Miscellaneous mycoses</topic><topic>Mycological Typing Techniques</topic><topic>Mycoses</topic><topic>non-sporing</topic><topic>non-sporulating</topic><topic>Pathology. 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Miscellaneous investigative techniques</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - diagnosis</topic><topic>Spleen - microbiology</topic><topic>Spores, Fungal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Callister, M E</creatorcontrib><creatorcontrib>Griffiths, M J</creatorcontrib><creatorcontrib>Nicholson, A G</creatorcontrib><creatorcontrib>Leonard, A</creatorcontrib><creatorcontrib>Johnson, E M</creatorcontrib><creatorcontrib>Polkey, M I</creatorcontrib><creatorcontrib>Kerr, J R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Callister, M E</au><au>Griffiths, M J</au><au>Nicholson, A G</au><au>Leonard, A</au><au>Johnson, E M</au><au>Polkey, M I</au><au>Kerr, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>57</volume><issue>9</issue><spage>991</spage><epage>992</epage><pages>991-992</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granulomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1–D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>15333665</pmid><doi>10.1136/jcp.2003.014449</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult aspergillosis Aspergillosis - diagnosis Aspergillus fumigatus Aspergillus fumigatus - isolation & purification Aspergillus fumigatus - physiology Biological and medical sciences Case Reports Fatal Outcome Female Human mycoses Humans Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Liver - microbiology Lung Diseases, Fungal - diagnosis Lymph Nodes - microbiology Medical sciences Miscellaneous mycoses Mycological Typing Techniques Mycoses non-sporing non-sporulating Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pregnancy Pregnancy Complications, Infectious - diagnosis Spleen - microbiology Spores, Fungal |
| title | A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus |
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