Genetic pathways to melanoma tumorigenesis

The incidence of cutaneous malignant melanomas is growing faster than that of any other cancer and therefore posing a major heath threat worldwide. In melanocytic skin tumours, the feasibility of correlating a specific pathological stage with a corresponding genetic alteration provides a remarkable...

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Veröffentlicht in:	Journal of clinical pathology 2004-08, Vol.57 (8), p.797-801
1. Verfasser:	Hussein, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	allelic loss Antigens Biological and medical sciences Cell cycle Chromosome Fragility CMM common acquired melanocytic naevus Defects Deoxyribonucleic acid Dermatology DNA Gene expression Genes, Tumor Suppressor high microsatellite instability hMSH HNPCC human MutS homologue human non-polyposis colorectal cancer Humans Hypotheses Investigative techniques, diagnostic techniques (general aspects) Kinases LOH Loss of Heterozygosity low microsatellite instability MDN Medical sciences Melanocytes - pathology melanocytic dysplastic naevi Melanoma Melanoma - genetics Melanoma - pathology Metastasis microsatellite instability Microsatellite Repeats mismatch repair MMR Models, Genetic MSI MSI-H MSI-L Mutation Nevus - pathology Oligonucleotide Array Sequence Analysis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques primary melanoma Proteins radial growth phase Reviews RGP Rodents Skin Neoplasms - genetics Skin Neoplasms - pathology TSG Tumorigenesis Tumors of the skin and soft tissue. Premalignant lesions tumour suppressor gene vertical growth phase VGP
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