The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas
Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this stud...
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| Veröffentlicht in: | Journal of clinical pathology 2004-02, Vol.57 (2), p.168-171 |
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| creator | Stafford, N D Condon, L T Rogers, M J C Helboe, L Crooks, D A Atkin, S L |
| description | Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present in acoustic neuromas. Methods: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. Results: SSTR2 was the most prevalent subtype in Schwann cells (seven of eight), with intermediate expression of SSTR3 (six of eight), and lower expression of SSTRs 1 and 5 (four of eight and five of eight, respectively). There was ubiquitous vascular expression of SSTR2, with no evidence of SSTR 1, 3, or 5 expression in blood vessels. Conclusion: SSTRs 1, 2, 3, and 5 are differentially expressed in acoustic neuromas. Somatostatin analogues may have a therapeutic role in the management of this rare and challenging condition. |
| doi_str_mv | 10.1136/jcp.2003.007260 |
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Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present in acoustic neuromas. Methods: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. Results: SSTR2 was the most prevalent subtype in Schwann cells (seven of eight), with intermediate expression of SSTR3 (six of eight), and lower expression of SSTRs 1 and 5 (four of eight and five of eight, respectively). There was ubiquitous vascular expression of SSTR2, with no evidence of SSTR 1, 3, or 5 expression in blood vessels. Conclusion: SSTRs 1, 2, 3, and 5 are differentially expressed in acoustic neuromas. Somatostatin analogues may have a therapeutic role in the management of this rare and challenging condition.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2003.007260</identifier><identifier>PMID: 14747443</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>acoustic neuroma ; Adult ; Aged ; Biological and medical sciences ; bovine serum albumin ; BSA ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Endothelium, Vascular - metabolism ; Female ; horseradish peroxidase conjugated streptavidin–biotin complex ; HRP-StrepABC ; Humans ; immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Neoplasm Proteins - metabolism ; Neuroma, Acoustic - blood supply ; Neuroma, Acoustic - metabolism ; Original ; Otorhinolaryngology. Stomatology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; PBS ; phosphate buffered saline ; Receptors, Somatostatin - metabolism ; Schwann Cells - metabolism ; somatostatin ; somatostatin receptor ; somatostatin receptors ; somatotroph release inhibiting factor ; SRIF ; SSTR ; Tumors</subject><ispartof>Journal of clinical pathology, 2004-02, Vol.57 (2), p.168-171</ispartof><rights>Copyright 2004 Journal of Clinical Pathology</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2004 Copyright 2004 Journal of Clinical Pathology</rights><rights>Copyright © Copyright 2004 Journal of Clinical Pathology 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b625t-ec0dae13ee2fa0d053a72e79c2c5f9ffea72d1d7048bdad7a7871acf3f0439313</citedby><cites>FETCH-LOGICAL-b625t-ec0dae13ee2fa0d053a72e79c2c5f9ffea72d1d7048bdad7a7871acf3f0439313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770210/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770210/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15485336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14747443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stafford, N D</creatorcontrib><creatorcontrib>Condon, L T</creatorcontrib><creatorcontrib>Rogers, M J C</creatorcontrib><creatorcontrib>Helboe, L</creatorcontrib><creatorcontrib>Crooks, D A</creatorcontrib><creatorcontrib>Atkin, S L</creatorcontrib><title>The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present in acoustic neuromas. Methods: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. Results: SSTR2 was the most prevalent subtype in Schwann cells (seven of eight), with intermediate expression of SSTR3 (six of eight), and lower expression of SSTRs 1 and 5 (four of eight and five of eight, respectively). There was ubiquitous vascular expression of SSTR2, with no evidence of SSTR 1, 3, or 5 expression in blood vessels. Conclusion: SSTRs 1, 2, 3, and 5 are differentially expressed in acoustic neuromas. Somatostatin analogues may have a therapeutic role in the management of this rare and challenging condition.</description><subject>acoustic neuroma</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>bovine serum albumin</subject><subject>BSA</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Female</subject><subject>horseradish peroxidase conjugated streptavidin–biotin complex</subject><subject>HRP-StrepABC</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neuroma, Acoustic - blood supply</subject><subject>Neuroma, Acoustic - metabolism</subject><subject>Original</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>PBS</subject><subject>phosphate buffered saline</subject><subject>Receptors, Somatostatin - metabolism</subject><subject>Schwann Cells - metabolism</subject><subject>somatostatin</subject><subject>somatostatin receptor</subject><subject>somatostatin receptors</subject><subject>somatotroph release inhibiting factor</subject><subject>SRIF</subject><subject>SSTR</subject><subject>Tumors</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkt-LEzEQxxdRvHr67JsERB-k28uP3c32RTiKp0JRH07vMWSzkzZ1N-klu6L_vVNa7npSkEBCMp_5JjP5ZtlLRmeMiepiY7YzTqmYUSp5RR9lE1ZInhesqB5nE0o5y-eyqM6yZyltKGVCMvE0O0MIRyEmWXO9BuL6fvRh7dIQzBp6Z3RHuoCzS3pwwZNgSQq9HkIa8MCTCAa2Q4iJsCnhUyKmRPuWlARj2oQxDc4QD2PEpPQ8e2J1l-DFYT3Pvl99uF58ypdfP35eXC7zpuLlkIOhrQYmALjVtKWl0JKDnBtuSju3FnDbslbSom5a3Uota8m0scLSQswFE-fZ-73udmx6aA34IepObaPrdfyjgnbqYcS7tVqFX4pJiY2iKPD2IBDD7QhpUL1LBrpOe8CaVE0ZqyWtEXz9D7gJY_RYHGrVjHJeV0fUSnegnLcBbzU7SXXJWEEZLaoKqfwEtQIP-MTgwTo8fsDPTvA42t3HnUy42CeYGFKKYO86wqjamUihidTORGpvIsx4ddzIe_7gGgTeHACd0CU2am9cuufKoi6FOKoNnQW_7-I6_lSVFLJUX34s1M1SljdXNVPfkH-355t-899X_gXK7epf</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Stafford, N D</creator><creator>Condon, L T</creator><creator>Rogers, M J C</creator><creator>Helboe, L</creator><creator>Crooks, D A</creator><creator>Atkin, S L</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>Copyright 2004 Journal of Clinical Pathology</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040201</creationdate><title>The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas</title><author>Stafford, N D ; Condon, L T ; Rogers, M J C ; Helboe, L ; Crooks, D A ; Atkin, S L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b625t-ec0dae13ee2fa0d053a72e79c2c5f9ffea72d1d7048bdad7a7871acf3f0439313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>acoustic neuroma</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>bovine serum albumin</topic><topic>BSA</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Female</topic><topic>horseradish peroxidase conjugated streptavidin–biotin complex</topic><topic>HRP-StrepABC</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neuroma, Acoustic - blood supply</topic><topic>Neuroma, Acoustic - metabolism</topic><topic>Original</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>PBS</topic><topic>phosphate buffered saline</topic><topic>Receptors, Somatostatin - metabolism</topic><topic>Schwann Cells - metabolism</topic><topic>somatostatin</topic><topic>somatostatin receptor</topic><topic>somatostatin receptors</topic><topic>somatotroph release inhibiting factor</topic><topic>SRIF</topic><topic>SSTR</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stafford, N D</creatorcontrib><creatorcontrib>Condon, L T</creatorcontrib><creatorcontrib>Rogers, M J C</creatorcontrib><creatorcontrib>Helboe, L</creatorcontrib><creatorcontrib>Crooks, D A</creatorcontrib><creatorcontrib>Atkin, S L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stafford, N D</au><au>Condon, L T</au><au>Rogers, M J C</au><au>Helboe, L</au><au>Crooks, D A</au><au>Atkin, S L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>57</volume><issue>2</issue><spage>168</spage><epage>171</epage><pages>168-171</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present in acoustic neuromas. Methods: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. Results: SSTR2 was the most prevalent subtype in Schwann cells (seven of eight), with intermediate expression of SSTR3 (six of eight), and lower expression of SSTRs 1 and 5 (four of eight and five of eight, respectively). There was ubiquitous vascular expression of SSTR2, with no evidence of SSTR 1, 3, or 5 expression in blood vessels. Conclusion: SSTRs 1, 2, 3, and 5 are differentially expressed in acoustic neuromas. Somatostatin analogues may have a therapeutic role in the management of this rare and challenging condition.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>14747443</pmid><doi>10.1136/jcp.2003.007260</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acoustic neuroma Adult Aged Biological and medical sciences bovine serum albumin BSA Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Endothelium, Vascular - metabolism Female horseradish peroxidase conjugated streptavidin–biotin complex HRP-StrepABC Humans immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Neoplasm Proteins - metabolism Neuroma, Acoustic - blood supply Neuroma, Acoustic - metabolism Original Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques PBS phosphate buffered saline Receptors, Somatostatin - metabolism Schwann Cells - metabolism somatostatin somatostatin receptor somatostatin receptors somatotroph release inhibiting factor SRIF SSTR Tumors |
| title | The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas |
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