Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study

Background: Two cell specific neutral proteases, tryptase and chymase, are produced by human mast cells (MC). Tryptase is constitutively expressed by all MC, whereas chymase is found only in an MC subset. Very little is known about chymase expression in MC proliferative disorders (mastocytosis). Aim...

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Veröffentlicht in:	Journal of clinical pathology 2003-02, Vol.56 (2), p.103-106
Hauptverfasser:	Horny, H-P, Greschniok, A, Jordan, J-H, Menke, D M, Valent, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences bone marrow Bone Marrow Cells - enzymology Cell Count chymase chymase expressing Chymases Hematologic and hematopoietic diseases Humans Immunoenzyme Techniques Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis mast cell Mast cell disease Mast cells Mast Cells - enzymology mast cells expressing both tryptase and chymase mast cells expressing only chymase mast cells expressing only tryptase mastocytosis Mastocytosis - enzymology Mastocytosis - pathology MCC MCT MCTC MDS Medical sciences Myelodysplastic syndromes Myelodysplastic Syndromes - enzymology Myelodysplastic Syndromes - pathology Original Physiological aspects Serine Endopeptidases - metabolism tryptase tryptase expressing Tryptases
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