Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation

Aim: Ultraviolet light (UV) is known to cause DNA damage in the epidermis. The damaged DNA is repaired or deleted by apoptosis to prevent the generation of cancer. It has been suggested that a deficient apoptotic mechanism may predispose individuals to skin cancer. Therefore, the response of normal...

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Veröffentlicht in:	Journal of clinical pathology 2002-11, Vol.55 (11), p.829-833
Hauptverfasser:	Murphy, M, Mabruk, M J E M F, Lenane, P, Liew, A, McCann, P, Buckley, A, Flatharta, C O, Hevey, D, Billet, P, Robertson, W, Javed, S, Leader, M, Kay, E, Murphy, G M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - radiation effects Basal cell carcinoma BCC bcl-2-Associated X Protein Biological and medical sciences Biopsy Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Cell cycle Cell death Comparative analysis Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Deoxyribonucleic acid Dermatology Disease Susceptibility DNA DNA damage Evaluation Genes, p53 H&E haematoxylin and eosin Holidays & special occasions Humans Medical sciences Neoplasm Proteins - metabolism Original p53 pathway Patients Physiological aspects Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Recruitment Risk factors Skin - metabolism Skin - pathology Skin - radiation effects Skin cancer Skin Neoplasms - metabolism Skin Neoplasms - pathology solar simulated radiation SSC Statistics Sun Surveillance terminal deoxynucleotidyl transferase mediated dUTP nick end labelling Tumor Suppressor Protein p53 - metabolism Tumors of the skin and soft tissue. Premalignant lesions TUNEL ultraviolet light Ultraviolet radiation Ultraviolet Rays
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