Frontotemporal dementia: impact of P301L tau mutation on a healthy carrier

Frontotemporal dementia (FTD) is the second commonest form of dementia after Alzheimer’s disease, but its clinical and biological features are less well known. To uncover its earliest signs, we studied the main clinical, neuroimaging, and biochemical findings in an asymptomatic carrier from a three...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2004-11, Vol.75 (11), p.1607-1610
Hauptverfasser:	Alberici, A, Gobbo, C, Panzacchi, A, Nicosia, F, Ghidoni, R, Benussi, L, Hock, C, Papassotiropoulos, A, Liberini, P, Growdon, J H, Frisoni, G B, Villa, A, Zanetti, O, Cappa, S, Fazio, F, Binetti, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alzheimer’s disease Amino Acid Substitution - genetics Biological and medical sciences Brain Ischemia - diagnosis Brain Ischemia - genetics cerebrospinal fluid Child CSF Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - diagnosis Dementia - genetics Diseases of striated muscles. Neuromuscular diseases DNA Mutational Analysis Exons - genetics Female Frontal Lobe - blood supply frontotemporal dementia FTD Genetic Carrier Screening healthy controls Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical sciences Middle Aged Nerve Tissue Proteins - genetics Neurology Neuropsychological Tests Pedigree preclinical Reference Values Short Report single photon emission computed tomography and statistical parametric mapping SPECT SPECT-SPM tau mutation tau Proteins Tomography, Emission-Computed, Single-Photon
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