Misexpression of a bHLH gene, cNSCL1, results in abnormal brain development

NSCL1 is a basic helix‐loop‐helix transcription factor involved in the development of the nervous system. To elucidate its role in neurogenesis, we cloned chick NSCL1 (cNSCL1) and examined its expression pattern and the effect of its misexpression on brain development. cNSCL1 was predominantly expre...

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Veröffentlicht in:	Developmental dynamics 1999-07, Vol.215 (3), p.238-247
Hauptverfasser:	Li, Chuan‐Ming, Yan, Run‐Tao, Wang, Shu‐Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors bHLH Brain - abnormalities Brain - embryology Brain - metabolism brain development Cell Cycle cell proliferation Cerebellum - abnormalities Cerebellum - embryology Cerebellum - metabolism Chick Embryo differentiation DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology gene expression Gene Expression Regulation, Developmental Genetic Vectors - administration & dosage Genetic Vectors - genetics Helix-Loop-Helix Motifs - genetics Humans In Situ Hybridization Microinjections Molecular Sequence Data Morphogenesis - genetics Multigene Family Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology neurogenesis Prosencephalon - abnormalities Prosencephalon - embryology Prosencephalon - metabolism Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Specific Pathogen-Free Organisms Superior Colliculi - abnormalities Superior Colliculi - embryology Superior Colliculi - metabolism
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