Basal cell adenocarcinoma of the palate with squamous metaplasia
Basal cell adenocarcinoma is a rare salivary gland tumour, especially in minor glands. The clinical, histological, and immunohistochemical features of a case involving the palate are described. Formalin fixed, paraffin embedded sections of the tumour were examined in haematoxylin and eosin (H&E)...
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| Veröffentlicht in: | Journal of clinical pathology 2000-02, Vol.53 (2), p.153-156 |
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| description | Basal cell adenocarcinoma is a rare salivary gland tumour, especially in minor glands. The clinical, histological, and immunohistochemical features of a case involving the palate are described. Formalin fixed, paraffin embedded sections of the tumour were examined in haematoxylin and eosin (H&E) sections and also using immunostaining for cytokeratins 7, 8, 13, 14, 18, 19, vimentin, muscle specific actin (HHF35), and laminin. H&E sections showed that the tumour was composed mainly of basaloid cells and a striking feature was the presence of squamous metaplasia. Neural invasion was also conspicuous. Immunohistochemical reactions indicated that cytokeratin 14 was expressed by all tumour cells and vimentin by all cells except those in the areas of squamous metaplasia. The remaining cytokeratins and actin were present in some of the tumour cells, while laminin showed discreet positivity around cell arrangements. The foci of squamous metaplasia and the immunohistochemical findings are helpful in distinguishing basal cell adenocarcinoma from other salivary gland tumours which show basaloid cells. |
| doi_str_mv | 10.1136/jcp.53.2.153 |
| format | Article |
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The clinical, histological, and immunohistochemical features of a case involving the palate are described. Formalin fixed, paraffin embedded sections of the tumour were examined in haematoxylin and eosin (H&E) sections and also using immunostaining for cytokeratins 7, 8, 13, 14, 18, 19, vimentin, muscle specific actin (HHF35), and laminin. H&E sections showed that the tumour was composed mainly of basaloid cells and a striking feature was the presence of squamous metaplasia. Neural invasion was also conspicuous. Immunohistochemical reactions indicated that cytokeratin 14 was expressed by all tumour cells and vimentin by all cells except those in the areas of squamous metaplasia. The remaining cytokeratins and actin were present in some of the tumour cells, while laminin showed discreet positivity around cell arrangements. The foci of squamous metaplasia and the immunohistochemical findings are helpful in distinguishing basal cell adenocarcinoma from other salivary gland tumours which show basaloid cells.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.53.2.153</identifier><identifier>PMID: 10767834</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adult ; basal cell adenocarcinoma ; Biological and medical sciences ; Female ; Humans ; Medical sciences ; Metaplasia ; Neoplasm Proteins - metabolism ; Otorhinolaryngology. Stomatology ; Palatal Neoplasms - metabolism ; Palatal Neoplasms - pathology ; Palate - pathology ; salivary gland neoplasms ; Short Report ; Tropical medicine ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of clinical pathology, 2000-02, Vol.53 (2), p.153-156</ispartof><rights>COPYRIGHT © 2000 Journal of Clinical Pathology</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 COPYRIGHT (c) 2000 Journal of Clinical Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-1ac6d2414b7ca013c94f2eae3a55f241a1afa0d498be81b023ae9cfdf8856a673</citedby><cites>FETCH-LOGICAL-b507t-1ac6d2414b7ca013c94f2eae3a55f241a1afa0d498be81b023ae9cfdf8856a673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1763300/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1763300/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1263586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10767834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Sousa, Suzana Orsini Machado</creatorcontrib><creatorcontrib>Schwarzschild, Monica</creatorcontrib><creatorcontrib>de Araújo, Ney Soares</creatorcontrib><creatorcontrib>de Araújo, Vera Cavalcanti</creatorcontrib><title>Basal cell adenocarcinoma of the palate with squamous metaplasia</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Basal cell adenocarcinoma is a rare salivary gland tumour, especially in minor glands. The clinical, histological, and immunohistochemical features of a case involving the palate are described. Formalin fixed, paraffin embedded sections of the tumour were examined in haematoxylin and eosin (H&E) sections and also using immunostaining for cytokeratins 7, 8, 13, 14, 18, 19, vimentin, muscle specific actin (HHF35), and laminin. H&E sections showed that the tumour was composed mainly of basaloid cells and a striking feature was the presence of squamous metaplasia. Neural invasion was also conspicuous. Immunohistochemical reactions indicated that cytokeratin 14 was expressed by all tumour cells and vimentin by all cells except those in the areas of squamous metaplasia. The remaining cytokeratins and actin were present in some of the tumour cells, while laminin showed discreet positivity around cell arrangements. The foci of squamous metaplasia and the immunohistochemical findings are helpful in distinguishing basal cell adenocarcinoma from other salivary gland tumours which show basaloid cells.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>basal cell adenocarcinoma</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metaplasia</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Palatal Neoplasms - metabolism</subject><subject>Palatal Neoplasms - pathology</subject><subject>Palate - pathology</subject><subject>salivary gland neoplasms</subject><subject>Short Report</subject><subject>Tropical medicine</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1v1DAQxS0EosvCjTOKBIILWTzxV_aCgKUtSCtAULhaE8dhvSRxaidQ_vu6yqoUDpxGmvnp6b15hDwEugJg8sXeDCvBVsUKBLtFFsBVkXPg8jZZUFpAvlZcHpF7Me4pBaaA3SVHQJVUJeML8uoNRmwzY9s2w9r23mAwrvcdZr7Jxp3NBmxxtNkvN-6yeD5h56eYdXbEocXo8D6502Ab7YPDXJKvJ8dnm3f59uPp-83rbV4JqsYc0Mi6SL4qZTD5MGveFBYtQyGatEfABmnN12VlS6howdCuTVM3ZSkkSsWW5OWsO0xVZ2tj-zFgq4fgOgy_tUen_770bqe_-58alGSM0iTw9CAQ_Plk46g7F69yY29TJK2AMqXSS5fk8T_g3k-hT-GSVgkAXDCWqOczZYKPMdjm2gpQfVWMTsVowXShUzEJf3TT_g14biIBTw4ARoNtE7A3Lv7hCslEKROWz5iLo724PmP4odOTlNAfvm302dsvwD-ffNLbxD-b-arb_9_hJUqxsjw</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>de Sousa, Suzana Orsini Machado</creator><creator>Schwarzschild, Monica</creator><creator>de Araújo, Ney Soares</creator><creator>de Araújo, Vera Cavalcanti</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000201</creationdate><title>Basal cell adenocarcinoma of the palate with squamous metaplasia</title><author>de Sousa, Suzana Orsini Machado ; Schwarzschild, Monica ; de Araújo, Ney Soares ; de Araújo, Vera Cavalcanti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-1ac6d2414b7ca013c94f2eae3a55f241a1afa0d498be81b023ae9cfdf8856a673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>basal cell adenocarcinoma</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metaplasia</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Palatal Neoplasms - metabolism</topic><topic>Palatal Neoplasms - pathology</topic><topic>Palate - pathology</topic><topic>salivary gland neoplasms</topic><topic>Short Report</topic><topic>Tropical medicine</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Sousa, Suzana Orsini Machado</creatorcontrib><creatorcontrib>Schwarzschild, Monica</creatorcontrib><creatorcontrib>de Araújo, Ney Soares</creatorcontrib><creatorcontrib>de Araújo, Vera Cavalcanti</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Sousa, Suzana Orsini Machado</au><au>Schwarzschild, Monica</au><au>de Araújo, Ney Soares</au><au>de Araújo, Vera Cavalcanti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal cell adenocarcinoma of the palate with squamous metaplasia</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>53</volume><issue>2</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Basal cell adenocarcinoma is a rare salivary gland tumour, especially in minor glands. The clinical, histological, and immunohistochemical features of a case involving the palate are described. Formalin fixed, paraffin embedded sections of the tumour were examined in haematoxylin and eosin (H&E) sections and also using immunostaining for cytokeratins 7, 8, 13, 14, 18, 19, vimentin, muscle specific actin (HHF35), and laminin. H&E sections showed that the tumour was composed mainly of basaloid cells and a striking feature was the presence of squamous metaplasia. Neural invasion was also conspicuous. Immunohistochemical reactions indicated that cytokeratin 14 was expressed by all tumour cells and vimentin by all cells except those in the areas of squamous metaplasia. The remaining cytokeratins and actin were present in some of the tumour cells, while laminin showed discreet positivity around cell arrangements. The foci of squamous metaplasia and the immunohistochemical findings are helpful in distinguishing basal cell adenocarcinoma from other salivary gland tumours which show basaloid cells.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>10767834</pmid><doi>10.1136/jcp.53.2.153</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult basal cell adenocarcinoma Biological and medical sciences Female Humans Medical sciences Metaplasia Neoplasm Proteins - metabolism Otorhinolaryngology. Stomatology Palatal Neoplasms - metabolism Palatal Neoplasms - pathology Palate - pathology salivary gland neoplasms Short Report Tropical medicine Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Basal cell adenocarcinoma of the palate with squamous metaplasia |
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