Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors

Daily αvβ5 integrin‐dependent phagocytosis of spent photoreceptor outer segment fragments by the retinal pigment epithelium (RPE) is critical for retinal function. This study identifies a key role for focal adhesion kinase (FAK) in RPE phagocytosis. Particle binding increases FAK complex formation w...

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Veröffentlicht in:	The EMBO journal 2003-08, Vol.22 (16), p.4143-4154
1. Verfasser:	Finnemann, Silvia C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adhesion Animals c-Mer Tyrosine Kinase Cell Adhesion Cell Adhesion Molecules - metabolism Cell Line EMBO05 EMBO20 Fibroblasts - cytology Fibroblasts - enzymology Fibroblasts - metabolism focal adhesion kinase Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Green Fluorescent Proteins integrins Integrins - metabolism Kinetics Luminescent Proteins - metabolism MerTK Mice Phagocytosis Phosphorylation Photoreceptor Cells - metabolism Pigment Epithelium of Eye - cytology Pigment Epithelium of Eye - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Rats Rats, Long-Evans Rats, Mutant Strains Receptor Protein-Tyrosine Kinases - metabolism Receptors, Vitronectin - metabolism retinal pigment epithelium Rod Cell Outer Segment - metabolism Signal Transduction Transfection
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