Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease
OBJECTIVES: To study the role of occupational exposures to solvents and aluminium in the aetiology of Alzheimer's disease (AD). An industrial hygienist rated exposure. METHODS: 89 subjects diagnosed with probable AD were matched by age, sex, and type of informant to 89 controls. Subjects were i...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 1998-09, Vol.55 (9), p.627-633 |
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| creator | Graves, A B Rosner, D Echeverria, D Mortimer, J A Larson, E B |
| description | OBJECTIVES: To study the role of occupational exposures to solvents and aluminium in the aetiology of Alzheimer's disease (AD). An industrial hygienist rated exposure. METHODS: 89 subjects diagnosed with probable AD were matched by age, sex, and type of informant to 89 controls. Subjects were identified from a large health maintenance organisation in Seattle, WA. A complete occupational history was obtained from spouses of cases and controls as well as from controls themselves. After the interview an industrial hygienist, blinded to case-control status, rated exposures. RESULTS: Non-significant associations were found between AD and ever having been occupationally exposed to solvents (odds ratio (OR) 1.77, 95% confidence interval (95% CI) 0.81 to 3.90) and aluminium (OR 1.46, 95% CI 0.62 to 3.42). Although an increasing risk was found with increasing number of years of exposure to solvents, there was an inverse association between exposure intensity and AD, and measures of cumulative exposure taking into account both intensity and duration of exposure were not significant. Analysis of the age at which half the cumulative exposure to solvents was achieved showed that an older age incurred a greater risk of AD than a younger age. However, the total amount of exposure carried no risk. CONCLUSIONS: The results suggest that lifetime occupational exposure to solvents and aluminium are not likely to be important risk factors for Alzheimer's disease. |
| doi_str_mv | 10.1136/oem.55.9.627 |
| format | Article |
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An industrial hygienist rated exposure. METHODS: 89 subjects diagnosed with probable AD were matched by age, sex, and type of informant to 89 controls. Subjects were identified from a large health maintenance organisation in Seattle, WA. A complete occupational history was obtained from spouses of cases and controls as well as from controls themselves. After the interview an industrial hygienist, blinded to case-control status, rated exposures. RESULTS: Non-significant associations were found between AD and ever having been occupationally exposed to solvents (odds ratio (OR) 1.77, 95% confidence interval (95% CI) 0.81 to 3.90) and aluminium (OR 1.46, 95% CI 0.62 to 3.42). Although an increasing risk was found with increasing number of years of exposure to solvents, there was an inverse association between exposure intensity and AD, and measures of cumulative exposure taking into account both intensity and duration of exposure were not significant. Analysis of the age at which half the cumulative exposure to solvents was achieved showed that an older age incurred a greater risk of AD than a younger age. However, the total amount of exposure carried no risk. CONCLUSIONS: The results suggest that lifetime occupational exposure to solvents and aluminium are not likely to be important risk factors for Alzheimer's disease.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.55.9.627</identifier><identifier>PMID: 9861186</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Aged, 80 and over ; Aluminum ; Aluminum - adverse effects ; Alzheimer Disease - chemically induced ; Alzheimer's disease ; Alzheimers disease ; Biological and medical sciences ; Case control studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Disease risk ; Dose response relationship ; Female ; Humans ; Industrial hygiene ; Male ; Medical sciences ; Neurology ; Occupational Diseases - chemically induced ; Occupational exposure ; Occupational Exposure - adverse effects ; Predisposing factors ; Risk Factors ; Solvents ; Solvents - adverse effects ; Spouses</subject><ispartof>Occupational and environmental medicine (London, England), 1998-09, Vol.55 (9), p.627-633</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Sep 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b622t-3e85c6fd8ee842001c15cc0a873c81f5005f2204dd93fd9104c5d97ebd9bb6523</citedby><cites>FETCH-LOGICAL-b622t-3e85c6fd8ee842001c15cc0a873c81f5005f2204dd93fd9104c5d97ebd9bb6523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27730994$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27730994$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2379697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9861186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graves, A B</creatorcontrib><creatorcontrib>Rosner, D</creatorcontrib><creatorcontrib>Echeverria, D</creatorcontrib><creatorcontrib>Mortimer, J A</creatorcontrib><creatorcontrib>Larson, E B</creatorcontrib><title>Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>OBJECTIVES: To study the role of occupational exposures to solvents and aluminium in the aetiology of Alzheimer's disease (AD). An industrial hygienist rated exposure. METHODS: 89 subjects diagnosed with probable AD were matched by age, sex, and type of informant to 89 controls. Subjects were identified from a large health maintenance organisation in Seattle, WA. A complete occupational history was obtained from spouses of cases and controls as well as from controls themselves. After the interview an industrial hygienist, blinded to case-control status, rated exposures. RESULTS: Non-significant associations were found between AD and ever having been occupationally exposed to solvents (odds ratio (OR) 1.77, 95% confidence interval (95% CI) 0.81 to 3.90) and aluminium (OR 1.46, 95% CI 0.62 to 3.42). Although an increasing risk was found with increasing number of years of exposure to solvents, there was an inverse association between exposure intensity and AD, and measures of cumulative exposure taking into account both intensity and duration of exposure were not significant. Analysis of the age at which half the cumulative exposure to solvents was achieved showed that an older age incurred a greater risk of AD than a younger age. However, the total amount of exposure carried no risk. CONCLUSIONS: The results suggest that lifetime occupational exposure to solvents and aluminium are not likely to be important risk factors for Alzheimer's disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aluminum</subject><subject>Aluminum - adverse effects</subject><subject>Alzheimer Disease - chemically induced</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Biological and medical sciences</subject><subject>Case control studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Disease risk</subject><subject>Dose response relationship</subject><subject>Female</subject><subject>Humans</subject><subject>Industrial hygiene</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Predisposing factors</subject><subject>Risk Factors</subject><subject>Solvents</subject><subject>Solvents - adverse effects</subject><subject>Spouses</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkktv1DAUhSMEKqWwY4sUCUQ3ZPDb8QapGlFAGlHEa8HGcuwb6mkSD3ZSFX49DjOaFhZlZVvn0_G5j6J4jNECYypeBugXnC_UQhB5pzjETKJKKiLu5jvluEIS4_vFg5TWCGEqKTkoDlQtMK7FYfHtzNppY0YfBtOVcLUJaYqQyjGUKXSXMIypNIMrTTf1fvBT_-cFafS9GcGV0aeLMrTlSffrHHwP8TiVzicwCR4W91rTJXi0O4-KL6evPy_fVquzN--WJ6uqEYSMFYWaW9G6GqBmJEe0mFuLTC2prXHLEeItIYg5p2jrFEbMcqckNE41jeCEHhWvtr6bqenB2Zw5mk5vYo4Yf-pgvP5bGfy5_h4uNZZcCsqywfHOIIYfU65N9z5Z6DozQJiSloxiTCiev3p-K0kkY4LmHv8PxNlTSDT__fQfcB2mmGcxMxIzIhhTmXqxpWwMKUVo99VhpOcl0HkJNOda6bwEGX9ysyN7eDf1rD_b6SZZ07XRDNanPUaoVELdsFmnMcRrWUqKlJqzV1vdpxGu9rqJF1pIKrl-_3WpPyxXVJDTj_rTdZ-bfn17Ab8BwQLf-Q</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Graves, A B</creator><creator>Rosner, D</creator><creator>Echeverria, D</creator><creator>Mortimer, J A</creator><creator>Larson, E B</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7QF</scope><scope>8FD</scope><scope>JG9</scope><scope>7QQ</scope><scope>7TB</scope><scope>FR3</scope><scope>KR7</scope><scope>5PM</scope></search><sort><creationdate>19980901</creationdate><title>Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease</title><author>Graves, A B ; Rosner, D ; Echeverria, D ; Mortimer, J A ; Larson, E B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b622t-3e85c6fd8ee842001c15cc0a873c81f5005f2204dd93fd9104c5d97ebd9bb6523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aluminum</topic><topic>Aluminum - adverse effects</topic><topic>Alzheimer Disease - chemically induced</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Biological and medical sciences</topic><topic>Case control studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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Database</collection><collection>Ceramic Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graves, A B</au><au>Rosner, D</au><au>Echeverria, D</au><au>Mortimer, J A</au><au>Larson, E B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>55</volume><issue>9</issue><spage>627</spage><epage>633</epage><pages>627-633</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>OBJECTIVES: To study the role of occupational exposures to solvents and aluminium in the aetiology of Alzheimer's disease (AD). An industrial hygienist rated exposure. METHODS: 89 subjects diagnosed with probable AD were matched by age, sex, and type of informant to 89 controls. Subjects were identified from a large health maintenance organisation in Seattle, WA. A complete occupational history was obtained from spouses of cases and controls as well as from controls themselves. After the interview an industrial hygienist, blinded to case-control status, rated exposures. RESULTS: Non-significant associations were found between AD and ever having been occupationally exposed to solvents (odds ratio (OR) 1.77, 95% confidence interval (95% CI) 0.81 to 3.90) and aluminium (OR 1.46, 95% CI 0.62 to 3.42). Although an increasing risk was found with increasing number of years of exposure to solvents, there was an inverse association between exposure intensity and AD, and measures of cumulative exposure taking into account both intensity and duration of exposure were not significant. Analysis of the age at which half the cumulative exposure to solvents was achieved showed that an older age incurred a greater risk of AD than a younger age. However, the total amount of exposure carried no risk. CONCLUSIONS: The results suggest that lifetime occupational exposure to solvents and aluminium are not likely to be important risk factors for Alzheimer's disease.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>9861186</pmid><doi>10.1136/oem.55.9.627</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Occupational and environmental medicine (London, England), 1998-09, Vol.55 (9), p.627-633 |
| issn | 1351-0711 1470-7926 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Aluminum Aluminum - adverse effects Alzheimer Disease - chemically induced Alzheimer's disease Alzheimers disease Biological and medical sciences Case control studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Disease risk Dose response relationship Female Humans Industrial hygiene Male Medical sciences Neurology Occupational Diseases - chemically induced Occupational exposure Occupational Exposure - adverse effects Predisposing factors Risk Factors Solvents Solvents - adverse effects Spouses |
| title | Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease |
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