Limitations of sniff nasal pressure in patients with severe neuromuscular weakness

Background: Inspiratory muscle strength in patients with neuromuscular disorders can be assessed using sniff inspiratory nasal pressure (Pnsn) and maximum inspiratory mouth pressure (PImax). However, the relative merits of Pnsn against PImax are not known in patients with severe neuromuscular diseas...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2003-12, Vol.74 (12), p.1685-1687
Hauptverfasser:	Hart, N, Polkey, M I, Sharshar, T, Falaize, L, Fauroux, B, Raphaël, J C, Lofaso, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Agreements Biological and medical sciences Congenital diseases Diseases of striated muscles. Neuromuscular diseases Female FRC functional residual capacity Guillain-Barre syndrome Humans Inhalation - physiology Inspiratory Capacity - physiology inspiratory mouth pressure inspiratory muscle strength Male Medical sciences Middle Aged Mouth - physiopathology Muscular dystrophy Nasal Cavity - physiopathology Neurology neuromuscular disease Neuromuscular diseases Neuromuscular Diseases - physiopathology NIV non-invasive ventilation PImax Pnsn Regression analysis Reproducibility of Results Respiration Respiratory muscles Respiratory Muscles - physiopathology Rhinomanometry Severity of Illness Index sniff inspiratory nasal pressure Testing vital capacity
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Zusammenfassung:	Background: Inspiratory muscle strength in patients with neuromuscular disorders can be assessed using sniff inspiratory nasal pressure (Pnsn) and maximum inspiratory mouth pressure (PImax). However, the relative merits of Pnsn against PImax are not known in patients with severe neuromuscular disease. Objective: To investigate whether severity of disease modifies the relation between Pnsn and PImax. Methods: Vital capacity (VC), Pnsn, and PImax were measured in 258 patients with neuromuscular disorders. Results: Data were analysed from 241 patients, 17 being unable to perform PImax or Pnsn manoeuvres. The correlation between Pnsn and PImax was +0.94 (p
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.74.12.1685